Pediatric combination vaccines

Current Opinion in Pediatrics

Volumn 11, Issue 1, 1999, Pages 14-20

  Choo, Sharon ^a   Finn, Adam ^a  

^a SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; DIPHTHERIA PERTUSSIS TETANUS VACCINE; HEPATITIS VACCINE; MEASLES MUMPS RUBELLA VACCINE; POLIOMYELITIS VACCINE; VACCINE;

CHILD; CHILD HEALTH; DRUG APPROVAL; DRUG CONJUGATION; FEMALE; HEALTH CARE COST; HUMAN; IMMUNIZATION; INFANT; INFECTION; MALE; MORBIDITY; MORTALITY; NEWBORN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVACCINATION; REVIEW; SEROLOGY;

CHILD; DIPHTHERIA-TETANUS-PERTUSSIS VACCINE; HAEMOPHILUS VACCINES; HEPATITIS B VACCINES; HUMANS; POLIOVIRUS VACCINE, INACTIVATED; VACCINES, COMBINED;

EID: 0032994482     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-199902000-00004     Document Type: Review

References (60)

1. Halperin BA, Eastwood BJ, Halperin SA: Comparison of parental and health care professional preferences for the acellular or whole cell pertussis vaccine. Pediatr Infect Dis J 1998, 17:103-109. This is a useful look at parent, physician, and nurse attitudes toward acellular pertussis vaccines and multiple injections.
2. Thorns ML, Bodnar PZ, O'Donovan JC, Gouel EG, Walcher JR, Halsey NA: Parental knowledge and choice regarding live and inactivated poliovirus vaccines. Arch Pediatr Adolesc Med 1997, 151:809-812.
3. Klein DL: Multicenter acellular pertussis vaccine trial: a National Institutes of Health perspective. Pediatrics 1995, 96:547-548.
4. Issaacson J, Trollfors B, Taranger J: Safety, immunogenicity and an open, retrospective study of efficacy of a monocomponent pertussis toxoid vaccine in infants. Pediatr Infect Dis J 1994, 13:22-27.
5. Decker MD, Edwards KM, Steinhoff MC, Rennels MB, Pichichero ME, Englund JA, et al.: Comparison of 13 acellular pertussis vaccines: adverse reactions. Pediatrics 1995, 96:557-566.
6. Edwards KM, Meade BD, Decker MD, Reed GF, Rennels MB, Steinhoff MCA, et al.: Comparison of 13 acellular pertussis vaccines: overview and serologic response. Pediatrics 1995, 96:548-557.
7. Edwards KM, Decker MD: Combination vaccines consisting of acellular pertussis vaccines. Pediatr Infect Dis J 1997, 16:97-102.
8. Greco D, Salmaso S, Mastrantonio P, Giuliano M, Tozzi AE, Anemone AC, et al.: A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. N Engl J Med 1996, 334:341-348.
9. Gustafsson L, Hallander HO, Olin P, Reizenstein E, Storsaeter J: A controlled trial of a two-component acellular, a five-component acellular, and a whole-cell pertussis vaccine. N Engl J Med 1996, 334:349-355.
10. Trollfors B, Taranger J, Lagergard T, Lind L, Sundh V, Zackrisson GL, et al.: A placebo-controlled trial of a pertussis-toxoid vaccine. N Engl J Med 1995, 333:1045-1050.
11. Schmitt HJ, von Koenig CH, Neiss A, Bogaerts H, Bock HLS, Schulte-Wisserman H, et al.: Efficacy of acellular pertussis vaccine in early childhood after household exposure. JAMA 1996, 275:37-41.
12. Olin P, Rasmussen F, Gustafsson L, Hallander HO, Heijbel H: Randomized controlled trial of two-component, three-component, and five-component acellular pertussis vaccines compared with whole-cell pertussis vaccine. Lancet 1997, 350:1569-1577.
13. Liese JG, Meschievitz CK, Harzer E, Froeschle J, Hosbach P, Hoppe JE, et al.: Efficacy of a two-component acellular pertussis vaccine in infants. Pediatr Infect Dis J 1997, 16:1038-1044.
14. Trollfors B, Taranger J, Lagergard T, Lind L, Sundh V, Zackrisson G, et al.: Efficacy of a monocomponent pertussis toxoid vaccine after household exposure to pertussis. J Pediatr 1997, 130:532-536.
15. Ferreccio C, Clemens J, Avendano A, Horwitz I, Flores C, Avila L, et al.: The clinical and immunologic response of Chilean infants to Haemophilus influenzae type b polysaccharide-tetanus protein conjugate vaccine coadministered in the same syringe with diphtheria-tetanus toxoids-pertussis vaccine at two, four and six months of age. Pediatr Infect Dis J 1991, 10:764-771.
16. Avendano A, Ferreccio C, Lagos R, Horwitz I, Cayazzo M, Fritzell B, et al.: Haemophilus influenzae type B polysaccharide-tetanus protein conjugate vaccine does not depress serologic responses to diphtheria, tetanus or pertussis antigens when coadministered in the same syringe with diphtheria-tetanus-pertussis vaccine at two, four and six months of age. Pediatr Infect Dis J 1993, 12:638-643.
17. Clemens JD, Ferreccio C, Levine MM, Horwitz I, Rao MR, Edwards KM, Fritzell B: Impact of Haemophilus influenzae type B polysaccharide-tetanus protein conjugate vaccine on responses to concurrently administered diphtheria-tetanus-pertussis vaccine. JAMA 1992, 267:673-678.
18. Jones IG, Tyrrell H, Hill A, Horobin JM, Taylor B: Randomized controlled trial of combined diphtheria, tetanus, whole-cell pertussis vaccine administered in the same syringe and separately with Haemophilus influenzae type B vaccine at two, three and four months of age. Vaccine 1998, 16:109-113.
19. Schmitt HJ, Zepp F, Muschenborn S, Sumenicht G, Schuind A, Beutel K, et al.: Immunogenicity and reactogenicity of a Haemophilus influenzae type B tetanus conjugate vaccine when administered separately or mixed with concomitant diphtheria-tetanus-toxoid and acellular pertussis vaccine for primary and for booster immunizations. Eur J Pediatr 1998, 157:208-214. This is a large and important study looking at the mixing of DTaP and HIB vaccines for primary and booster vaccinations.
20. Pichichero M, Latiolais T, Bernstein D, Hosbach P, Christian E, Vidor E, et al.: Vaccine antigen interactions after a combination diphtheria-tetanus toxoid-acellular pertussis/purified capsular polysaccharide of Haemophilus influenzae type B-tetanus toxoid vaccine in two-, four- and six-month-old infants. Pediatr Infect Dis J 1997, 16:863-870. This is also an important study of another Dtap-HIB vaccine combination for infants.
21. Bell F, Heath P, Shackley F, MacLennan J, Shearstone N, Diggle L, et al.: Effect of combination with an acellular pertussis, diphtheria, tetanus vaccine on antibody response to HIB vaccine (PRP-T). Vaccine 1998, 16:637-642.
22. Chiu H, Huang L, Lee P, Safary A, Lee C: Diphtheria, tetanus and whole cell pertussis vaccine combined with hepatitis B vaccines: a comparison of two doses. Pediatr Infect Dis J 1998, 17:206-211.
23. Papaevangelou G, Karvelis G, Alexiou D: Evaluation of a combined tetravalent diphtheria, tetanus, whole-cell pertussis and hepatitis B vaccine administered to healthy infants according to a three-dose vaccination schedule. Vaccine 1995, 13:175-178.
24. Salmaso S, Piscitelli A, Rapicetta M, Chionne P, Madonna E, Argentini C: Immunogenicity of Hepatitis B vaccines among infant recipients of acellular and whole cell pertussis DTP vaccines. Vaccine 1998, 16:643-646.
25. Giammanco G, Moiraghi A, Zotti C, Pignato S, Li Volti S, Giammanco A, Soncini R: Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered according to two different primary vaccination schedules. Vaccine 1998, 16:722-726.
26. Pichichero ME, Passador S: Administration of combined diphtheria and tetanus toxoids and pertussis vaccine, hepatitis B vaccine, and Haemophilus influenzae type B (HIB) vaccine to infants and response to a booster dose of HIB conjugate vaccine. Clin Infect Dis 1997, 25:1378-1384. This is a worthwhile study of a Dtap-HBV-HIB combination in infants that also looks at the response to an HIB conjugate booster.
27. Zepp F, Schmitt HJ, Kaufhold A, Schuind A, Knuf M, Habermehl P, et al.: Evidence for induction of polysaccharide specific B-cell-memory in the 1st year of life: plain Haemophilus influenzae type B: PRP (HIB) boosters children primed with a tetanus-conjugate HIB-DTPa-HBV combined vaccine. Eur J Pediatr 1997, 156:18-24. This important study of another two Dtap-HBV-HIB combinations assessed response to an HIB polysaccharide booster given with a Dtap-HBV booster.
28. Gold R, Scheifele D, Barreto L, Wiltsey S, Bjornson G, Meekison W, et al.: Safety and immunogenicity of Haemophilus influenzae vaccine (tetanus toxoid conjugate) administered concurrently or combined with diphtheria and tetanus toxoids, pertussis vaccine and inactivated poliomyelitis vaccine to healthy infants at 2, 4, and 6 months of age. Pediatr Infect Dis J 1994, 13:348-355.
29. Dagan R, Igbaria K, Piglansky L, Melamed R, Willems P, Grossi A, Kaufhold A: Safety and immunogenicity of a combined pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus and Haemophilus influenzae type B-tetanus conjugate vaccine in infants, compared with a whole cell pertussis pentavalent vaccine. Pediatr Infect Dis J 1997, 16:1113-1121.
30. Mills E, Gold R, Thipphawong J, Berreto L, Guasparini R, Meekison W, et al.: Safety and immunogenicity of a combined five-component pertussis-diphtheria-tetanus - inactivated poliomyelitis-Haemophilus B conjugate vaccine administered to infants at 2, 4, and 6 months of age. Vaccine 1998, 16:576-585.
31. Lagos R, Kotloff K, Hoffenbach A, Martin OS, Abrego P, Ureta AM, et al.: Clinical acceptability and immunogenicity of a pentavalent parenteral combination vaccine containing diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis and Haemophilus influenzae type B conjugate antigens in 2-, 4-, and 6-month old Chilean infants. Pediatr Infect Dis J 1998, 17:294-304. This paper reviews a large and interesting trial comparing 5 different regimens of DTaP, eIPV, and HIB vaccines in the primary series.
32. Eskola J, Olander R, Hovi T, Litmanen L, Peltola S, Kayhty H: randomized trial of the effect of co-administration with acellular pertussis DTP vaccine on immunogenicity of Haemophilus influenzae type B conjugate vaccine. Lancet 1996, 348:1688-1692.
33. Begue P, Stagnara J, Vie-le-sage F, Bernard JC, Xerri B, Abitol V: Immunogenicity and reactogenicity of a booster dose of diphtheria, tetanus, acellular pertussis and inactivated poliomyelitis vaccines given concurrently with Haemophilus type B conjugate vaccine or as pentavalent vaccine. Pediatr Infect Dis J 1997, 16:787-794.
34. Ambrosch F, Wiedermann G, Andre FE: Clinical and immunological investigation of a new combined hepatitis A and hepatitis B vaccine. J Med Virol 1994, 44:452-456.
35. Bruguera M, Bayas J, Vilella A: Immunogenicity and reactogenicity of a combined hepatitis A and B vaccine in young adults. Vaccine 1996, 14:1407-1411.
36. Leroux-Roels G, Moreau E, Desombere I, Safary A: Safety and immunogenicity of a combined hepatitis A and hepatitis B vaccine in young healthy adults. Scand J Gastroenterol 1996, 31:1027-1031.
37. Joensuu J, Koskenniemi I, Vesikari T: Symptoms associated with rhesus-human reassortant rotavirus vaccine in infants. Pediatr Infect Dis J 1998, 17:334-340.
38. Santosham M, Moulton L, Reid R, Croll J, Weatherholt R, Ward R, et al.: Efficacy and safety of high-dose rhesus-human reassortant vaccine in Native American populations. J Pediatr 1997, 131:632-638.
39. Bernstein DI, Glass RI, Rogers G, Davidson BL, Sack DA: Evaluation of rhesus rotavirus monovalent and tetravalent reassortant vaccines in US children. JAMA 1995, 273:1191-1196.
40. Rennels MB, Glass RI, Dennehy PH, Bernstein DI, Pichichero ME, Davidson BL, Kapikian A: Safety and efficacy of high dose rhesus-human reassortant rotavirus vaccines: report of the national multicenter trial. Pediatrics 1996, 97:7-13.
41. White CJ, Stinson D, Staehle B, Cho J, Matthews H, Ngai A, et al.: Measles, mumps, rubella, varicella combination vaccine: safety and immunogenicity alone and in combination with other vaccines given to children. Clin Infect Dis 1997, 24:925-931.
42. Reuman PD, Sawyer MH, Kuter BJ, Matthews H: Safety and immunogenicity of concurrent administration of measles-mumps-rubella-varicella vaccine and PedvaxHIB vaccines in healthy children 12 to 18 months old. Pediatr Infect Dis J 1997, 16:662-667.
43. Fairley CK, Begg N, Borrow R, Fox AJ, Jones DM, Cartwright K: Conjugate meningococcal serogroup A and C vaccine: reactogenicity and immunogenicity in United Kingdom infants. J Infect Dis 1996, 174:1360-1363.
44. 197 vaccines: effect of saccharide size on immunogenicity and interactions with simultaneously administered vaccines. J Infect Dis 1997, 176:445-455.
45. Leach A, Twumasi PA, Kumah S, Banya WS, Jaffar S, Forrest BD, et al.: Induction of immunological memory in Gambian children by vaccination in infancy with a Group A plus Group C meningococcal polysaccharide-protein conjugate vaccine. J Infect Dis 1997, 175:200-204.
46. Ahman H, Kayhty H, Lehtonen H, Leroy O, Froesche J, Eskola J: Streptococcus pneumoniae capsular polysaccharide-diphtheria toxoid conjugate vaccine is immunogenic in early infancy and able to induce immunological memory. Pediatr Infect Dis J 1998, 17:211-216.
47. 197 in United States infants. Pediatrics 1996, 101:604-611.
48. Dagan N, Eskola J, Leclerc C, Leroy O: Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants. Infect Immun 1998, 66:2093-2098. This very interesting and worthwhile study focuses on the simultaneous administration of several vaccines containing the same protein component, ie, tetanus toxoid; an excellent study of carrier effects.
49. Siber GR, Anderson R, Habafy M, Gupta RK: Development of a guinea pig model to assess immunogenicity of Haemophilus influenzae type B capsular polysaccharide conjugate vaccines. Vaccine 1995, 13:525-531.
50. Lieberman JM, Greenberg DP, Wong VK, Partridge S, Chang SJ, Chiu CYW, Ward JI: Effect of neonatal immunization with diphtheria and tetanus toxoids on antibody responses to Haemophilus influenzae type B conjugate vaccines. J Pediatr 1995, 126:198-205.
51. Barington T, Skettrup M, Juul L, Heilmann C: Non-epitope-specific suppression of the antibody response to Haemophilus influenzae type B conjugate vaccines by preimmunization with vaccine components. Infect Immun 1993, 61:432-438.
52. Schneerson R, Robbins J, Chu C, Sutton A, Vann W, Vickers JC, et al.: Serum and antibody responses of juvenile and infant rhesus monkeys injected with Haemophilus influenzae type B and pneumococcus type 6A capsular polysaccharide-protein conjugate vaccines. Infect Immun 1984, 45:582-591.
53. Granoff DM, Holmes SJ, Belshe RB, Osterholm MT, McHugh JE, Anderson EL: Effect of carrier protein priming on antibody responses to Haemophilus influenzae type B conjugate vaccines in infants. JAMA 1994, 272:1116-1121.
54. Kurikka S; Priming with diphtheria-tetanus-pertussis vaccine enhances the response to the Haemophilus influenzae type B tetanus conjugate vaccine in infancy. Vaccine 1996, 14:1239-1242.
55. Insel RA: Potential alterations in immunogenicity by combining or simultaneously administering vaccine components. Ann N Y Acad Sci 1993, 754:35-47.
56. Robbins JB, Parke JC, Schneerson R, Whisnant JK: Quantitative measurement of "natural" and immunization-induced Haemophilus influenzae type b capsular polysaccharide antibodies. Pediatr Res 1973, 7:103-110.
57. Santosham M, Reid R, Ambrosino DM, Wolff MC, Almeido-Hill J, Priehs C, et al.: Prevention of Haemophilus influenzae type b infections in high-risk infants treated with bacterial polysaccharide immune globulin. N Engl J Med 1987, 317:923-929.
58. Peltola H, Kayhty H, Virtanen M, Makela P: Prevention of Haemophilus type B bacteremic infections with the capsular polysaccharide vaccine. N Engl J Med 1984, 310:1561-1566.
59. Eskola J, Kayhty H, Takala AK, Peltola H, Ronnberg PR, Kela E, et al.: A randomized, prospective field trial of a conjugate vaccine in the protection of infants and young children against invasive Haemophilus influenzae type B disease. N Engl J Med 1990, 323:1381-1387.
60. Heath PT, Bowen-Morris J, Griffiths D, Griffiths H, Crook DW, Moxon ER: Antibody persistence and Haemophilus influenzae type B carriage after infant immunization with PRP-T. Arch Dis Child 1998, 77:488-492.