Effects of starvation and bowel resection on paracellular permeability in rat small-bowel mucosa in vitro

Scandinavian Journal of Gastroenterology

Volumn 34, Issue 2, 1999, Pages 156-162

  Wirén, Mikael ^a   Soderholm J D ^b   Lindgren, J ^b   Olaison, G ^b   Permert, J ^b   Yang, H ^b   Larsson, J ^b  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

Permeability; Small intestine; Starvation; Surgery; Ussing chamber

Indexed keywords

EDETIC ACID; KETAMINE; XYLAZINE;

ABDOMINAL SURGERY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; INTESTINE ABSORPTION; INTESTINE RESECTION; MAINTENANCE THERAPY; MALE; MALNUTRITION; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE MUCOSA; STARVATION;

EID: 0032994418     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365529950173014     Document Type: Article

References (22)

1. Wirén M, Magnusson KE, Larsson J. Enteral glutamine increases growth and absorptive capacity of intestinal mucosa in the malnourished rat. Scand J Gastroenterol 1995;30:146-52.
2. Hillgren KH, Kato A, Borchardt RT. In vitro systems for studying intestinal drug absorption. Med Res Rev 1995;15:83-109.
3. Pantzar N, Weström BR, Lundin S. The in vitro transmural passage of different-sized dextrans and proteins/peptides in the proximal and distal rat small intestine. Scand J Gastroenterol 1993;28:205-11.
4. Biljsma PB, Peeters RA, Groot JA, Dekker PR, Taminiau JAJM, van der Meer R. Differential in vivo and in vitro intestinal permeability to lactulose and mannitol in animals and humans: a hypothesis. Gastroenterology 1995;108:687-96.
5. Söderholm JD, Hedman L, Artursson P, Franzén L, Larsson J, Pantzar N, et al. Integrity and metabolism of human ileal mucosa in vitro in Ussing chambers. Acta Physiol Scand 1998; 162:47-56.
6. Grass GM, Sweetana SA. In vitro measurements of gastrointestinal tissue permeability using a new diffusion cell. Pharmacol Res 1988;6:372-6.
7. Karlsson J. Drug absorption in cell culture models of the intestinal epithelium [dissertation]. Uppsala: Uppsala University; 1995.
8. Magnusson M, Magnusson K-E, Sundqvist T, Denneberg T. Increased intestinal permeability to differently sized polyethylene glycols in uremic rats: effects of low-and high-protein diets. Nephron 1990;56:306-11.
9. Worthington BS, Syrotuck J. Intestinal permeability to large particles in normal and protein-deficient adult rats. J Nutr 1976; 106:20-32.
10. Deitch EA, Ma WJ, Ma L, Berg R, Specian R. Protein malnutrition predisposes to inflammatory-induced gut-origin septic states. Ann Surg 1990;211:560-8.
11. Fong YM, Marano MA, Barber A, He W, Moldawer LL, Buchman ED, et al. Total parenteral nutrition and bowel rest modify the metabolic response to endotoxin in humans. Ann Surg 1989;210:449-56.
12. Mandel LJ, Bacallo R, Zampighi G. Uncoupling of the molecular fence and paracellular gate functions in epithelial tight junctions. Nature 1993;361:552-5.
13. Roumen RM, van der Vliet JA, Wevers RA, Goris RJ. Intestinal permeability is increased after major vascular surgery. J Vasc Surg 1993;17:734-7.
14. 2 reduces intestinal permeability during mesenteric ischemia. J Surg Res 1996;66:69-74.
15. Sigalet DL, Kneteman NM, Simpson I, Walker K, Thomson AB. Intestinal permeability after small intestinal transplantation and cyclosporine treatment. Transplant Proc 1992;24:1121-1.
16. De Blaauw I, Deutz N, van der Hulst R, von Meyenfeldt M. Glutamine depletion and increased gut permeability in non-anorectic, non-weight-losing tumour-bearing rats. Gastoenterology 1997;112:118-26.
17. Madsen KL, Brockway PD, Johnson LR, Hardin JA, Gall DG. Role of ornithine decarboxylase in enterocyte mitochondrial function and integrity. Am J Physiol 1996;270:G789-97.
18. Rhodes RS, Karnovsky MB. Loss of macromolecular barrier function associated with surgical trauma to the intestine. Lab Invest 1971;25:220-9.
19. Kato M, Suzuki H, Murakami M, Akama M, Matsukawa S, Hashimoto Y. Elevated plasma levels of interleukin-6, interleukin-8 and granulocyte colony-stimulating factor during and after major abdominal surgery. J Clin Anesth 1997;9:293-8.
20. Perez M, Barber A, Ponz F. Modulation of intestinal paracellular permeability by intracellular mediators and cytoskeleton. Can J Physiol Pharmacol 1997;75:287-92.
21. Unno N, Wang H, Menconi MJ, Smith M, Aguirre DE, Fink MP. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 1997;113:1246-57.
22. Smith PL. Methods for evaluating intestinal permeability and metabolism in vitro. Pharm Biotechnol 1996;8:13.