Effect of the nitric oxide inhibitor, L-N(G)-monomethylarginine, on accumulation of interleukin-6 and interleukin-8, and nuclear factor-κB activity in a human endothelial cell line

Critical Care Medicine

Volumn 27, Issue 5, 1999, Pages 908-912

  Galley, Helen F ^a   Nelson, Simon J ^b   Dhillon, Jatinder ^b   Dubbels, Anne M ^b   Webster, Nigel R ^b  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b NONE

Author keywords

Cytokine; Endothelium; Interleukin 6; Interleukin 8; L N(G) monomethylarginine; Nitric oxide; Nuclear factor B; Septicemia; Transcription factors

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; SEPSIS; TREATMENT OUTCOME;

CELL LINE; CULTURE MEDIA; DRUG EVALUATION, PRECLINICAL; ENDOTHELIUM; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; INTERLEUKIN-8; NF-KAPPA B; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; SHOCK, SEPTIC; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032994207     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199905000-00024     Document Type: Article

References (48)

1. 1. Kilbourn RG, Griffith OW: Overproduction of nitric oxide in cytokine mediated septic shock. J Natl Cancer Inst 1992; 84:827-831
2. 2. Goode HF, Howdle, BE, Walker BE, et al: Nitric oxide synthase activity is increased in patients with sepsis syndrome. Clin Sci 1995; 88:131-133
3. 3. Goode HF, Cowley HC, Walker BE, et al: Decreased antioxidant status and increased lipid peroxidation in patients with sepsis and secondary organ dysfunction. Crit Care Med 1995; 23: 646-651
4. 4. Wong HR, Carcillo JA, Burckhart G, et al: Increased serum nitrite and nitrate concentrations in children with the sepsis syndrome. Crit Care Med 1995; 23:835-842
5. 5. Gomez-Jumenez J, Salgado A, Mourelle M, et al: L-arginine: nitric oxide pathway in endotoxaemia and human septic shock. Crit Care Med 1995; 23: 253-258
6. 6. Galley HF, Webster NR: Plasma nitrate and nitrite concentrations are increased in patients who die from septic shock. Abstr. Intensive Care Med 1996; 22(Suppl 3):S327
7. 7. Offner F, Phillipe J, Vogelaers D, et al: Serum tumor necrosis factor levels in patients with infectious diseases and septic shock. J Lab Clin Med 1990; 116:100-105
8. 8. Damas P, Reuter A, Gysen P, et al: Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit Care Med 1989; 17: 975-978
9. 9. Dofferhoff AS, Bom VJ, de VriesHospers HG, et al: Patterns of cytokines, plasma endotoxin, plasminogen activator inhibitor and acute phase proteins during treatment of severe sepsis in humans. Crit Care Med 1992; 20: 185-192
10. 10. Casey LC, Balk RA, Bone RC: Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993; 119:771-778
11. 11. Pinsky MR, Vincent JL, Deviere J, et al: Serum cytokine levels in human septic shock: relation to multiple-system organ failure and mortality. Chest 1993; 103:565-575
12. 12. Hack CE, Hart M, van Schijndel RJ, et al: Interleukin-8 in sepsis: relation to shock and inflammatory mediators. Infect Immun 1992; 60:2835-2842
13. 13. Libermann TA, Baltimore D: Activation of interleukin-6 gene expression through the nuclear factor-kappa B transcription factor. Mol Cell Biol 1990; 10:2327-2334
14. 14. Kunsch C, Lang RK, Rosen CA, et al: Synergistic transcriptional activation of the IL-8 gene by NF kappa B p65 (RelA) and NF-IL-6. J Immunol 1994; 153: 153-164
15. 15. Baeuerle PA, Henkel T: Function and activation of NFK'B in the immune system. Annu Rev Immunol 1994; 12: 141-179
16. 16. van Oost BA, Edgell CJS, Hay CW: Isolation of human von Willebrand factor cDNA from the EA.hy926 cell line. Biochem Cell Biol 1986; 95:355-360
17. 17. Reiber AJ, Edgell CJS: Endothelium specific gene expression. Thromb Haemost 1989; 62:98
18. 18. Edgell CJS, Haizlip JE, Bagnell CR, et al: Endothelium specific Weibel-Palade bodies in a continuous human cell line, EA.hy926. In Vitro Cell Dev Biol 1990; 26:1167-1172
19. 15N nitrate in biological fluids. Anal Biochem 1982; 126:131-138
20. 20. Docherty K: Gene transcription: DNA binding protein, essential techniques. Chichester, Wiley, 1996.
21. 21. Schoedon G, Schneemann M, Blau N, et al: Modulation of human endothelial cell tetrahydrobiopterin synthesis by activating and deactivating cytokines. Biochem Biophys Res Commun 1993; 196:1343-1348
22. 22. Galley HF, Nelson SJ, Dubbels AM, et al: Effect of ciprofloxacin on the accumulation of interleukin-6, interleukin-8 and nitrite from an endothelial cell model of sepsis. Crit Care Med 1997; 25:1392-1395
23. 23. Gryglewski RJ, Botting RM, Vane JR: Mediators produced by the endothelial cell. Hypertension 1988; 12:530-548
24. 24. Galley HF, Walker BE, Howdle PD, et al: Regulation of nitric oxide synthase activity in cultured human endothelial cells: effects of antioxidants. Free Rad Biol Med 1996; 21:97-101
25. 25. Werner-Felmayer J, Werner ER, Weiss G, et al: Modulation of nitric oxide synthase activity in intact cells by intracellular tetrahydrobiopterin levels. Adv Exp Med Biol 1993; 338:309-312
26. 26. Rees DD, Monkhouse JE, Moncada S: 546C88 attenuates the fall in blood pressure and improves survival in a conscious instrumented mouse model of endotoxin shock. Abstr. Intensive Care Med 1995; 21(Suppl 1):S21
27. 27. Chollett-Martin S, Gatecell C, Kermarrec N, et al: Alveolar neutrophil functions and cytokine levels in patients with the adult respiratory distress syndrome during nitric oxide inhalation. Am J Respir Crit Care Med 1996; 153:985-990
28. 28. Endo S, Inarda K, Inoue Y, et al: Two types of septic shock classified by the plasma levels of cytokines and endotoxin. Circ Shock 1992; 38:264-274
29. 29. Barthlen W, Stadler J, Lehn NL, et al: Serum levels of end products of nitric oxide synthesis correlate positively with tumor necrosis factor alpha and negatively with body temperature in patients with postoperative abdominal sepsis. Shock 1994; 2:398-401
30. 30. Villarete LH, Remick DG: Nitric oxide regulation of IL-8 expression in human endothelial cells. Biochem Biophys Res Commun 1995; 211:671-676
31. 31. Hussein Z, Jordan B, Fook-Sheung C, et al: Pharmacokinetics of 546C88 in patients with septic shock: preliminary results. Abstr. Intensive Care Med 1995; 21(Suppl 1):S21
32. 32. Andrew PJ, Harant H, Lindley IJD: Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level. Biochem Biophys Res Commun 1995; 214:949-956
33. 33. Willis RA, Nussler AK, Fries KM, et al: Induction of nitric oxide synthase in subsets of murine pulmonary fibroblasts: effect on fibroblast interleukin 6 production. Clin Immunol Immunopathol 1994; 71:231-239
34. 34. Stadler J, Harbrecht BG, Di Silvio M, et al: Endogenous nitric oxide inhibits the synthesis of cyclo-oxygenase products and interleukin-6 by rat Kupffer cells. J Leukoc Biol 1993; 53:165-172
35. 35. Meyer TA, Tiao GM, James JH, et al. Nitric oxide inhibits LPS induced IL-6 production in enterocytes. J Surg Res 1995; 58:570-575
36. 36. Deakin AM, Payne AN, Whittle BJR, et al: The modulation of IL-6 and TNFα release by nitric oxide following stimulation of J774 cells with LPS and IFNO. Cytokine 1995; 7:408-416
37. 37. Meyer TA, Wang J, Tiao GM, et al: Sepsis and endotoxemia stimulate interleukin-6 production. Surgery 1995; 118:336-342
38. 38. Peng H-B, Libby P, Liao JK: Induction and stabilisation of IκBβ by nitric oxide mediates inhibition of NFκB. J Biol Chem 1995; 270:14214-14219
39. 39. De Caterina R, Libby P, Peng H-B, et al: Nitric oxide decreases cytokine-induced endothelial activation. J Clin Invest 1995; 96:60-68
40. 40. Matthews JR, Botting CH, Panico M, et al: Inhibition of NFκB DNA binding by nitric oxide. Nucleic Acids Res 1996; 24:2236-2242
41. 41. Moorman Am, Koenig RJ, Meshnick SR: Effects of hydrogen peroxide, nitric oxide and antioxidants on NFκB. Redox Report 1996; 2:249-256
42. 42. Park SK, Lin HL, Murphy S: Nitric oxide regulates nitric oxide synthase-2 gene expression by inhibiting NFκB binding to DNA. Biochem J 1997; 322:609-613
43. 43. Anderson MT, Staal FJ, Gitler C, et al: Separation of oxidant-initiated and redox-regulated steps in the NF kappa B signal transduction pathway. Proc Natl Acad Sci USA 1994; 912:11527-11531
44. 44. Akira S, Isshiki H, Nakajima T, et al: Regulation of expression of the interleukin-6 gene. Ciba Found Symp 1992; 167:47-62
45. 45. Yasumoto K, Okamoto S, Mukaida N, et al: Tumor necrosis factor a and interferon (synergistically induce interleukin-8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NFκB-like binding sites of the interleukin-8 gene. J Biol Chem 1992; 267:22506-22511
46. 46. Zhang H, Spapen H, Nguyen DN, et al: Protective effects of N-acetyl-L-cysteine in endotoxemia. Am J Physiol 1994; 266:H1746-H1754
47. 47. Wang P, Wu P, Siegel MI, et al: Interleukin-10 inhibits nuclear factor kappa B activation in human monocytes. J Biol Chem 1995; 270: 9558-9563
48. 48. Bohrer H, Qiu F, Zimmerman T, et al: Role of NFκB in the mortality of sepsis. J Clin Invest 1997; 100:972-985