The effect of lexipafant on bacterial translocation in acute necrotizing pancreatitis in rats

American Surgeon

Volumn 65, Issue 7, 1999, Pages 611-617

  Liu, Qiang ^a   Djuricin, Goldie ^a   Rossi, Heather ^a   Bewsey, Kelly ^a   Nathan, Catherine ^b   Gattuso, Paolo ^a   Weinstein, Robert A ^a,b   Prinz, Richard A ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Jr Hospital of Cook County   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; LEXIPAFANT; PLACEBO; TAUROCHOLIC ACID; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; TRYPSIN; TUMOR NECROSIS FACTOR ALPHA;

ACUTE HEMORRHAGIC PANCREATITIS; ANAEROBIC BACTERIUM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BACTERIAL INFECTION; BACTERIAL TRANSLOCATION; BACTERIUM CULTURE; BLEEDING; CECUM; CELL INFILTRATION; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE SEVERITY; EDEMA; FAT NECROSIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; INTRAPERITONEAL DRUG ADMINISTRATION; LAPAROTOMY; LIVER; MALE; MESENTERY LYMPH NODE; NONHUMAN; PANCREAS; PARENCHYMA; RAT; SPLEEN; SUPERINFECTION;

EID: 0032994189     PISSN: 00031348     EISSN: None     Source Type: Journal    
DOI: 10.1177/000313489906500703     Document Type: Conference Paper

References (32)

1. Kazantsev GB, Hecht DW, Rao R, et al. Plasmid labeling confirms bacterial translocation in pancreatitis. Am J Surg 1994; 167:201-7.
2. Formela LJ, Wood LM, Whittaker M, Kingsnorth AN. Amelioration of experimental acute pancreatitis with a potent platelet-activating factor antagonist. Br J Surg 1994;81:1783-5.
3. Kingsnorth AN, Galloway SW, Formela LJ. Randomized, double-blind phase II trial of Lexipafant, a platelet-activating factor antagonist, in human acute pancreatitis. Br J Surg 1995;82: 1414-20.
4. Travis SP, Jewell DP. The role of platelet-activating factor in the pathogenesis of gastrointestinal disease. Prostaglandins Leukot Essent Fatty Acids 1994;50:105-13.
5. Alonso R, Mointero A, Arevalo M, et al. Platelet-activating factor mediates pancreatic function derangement in caerulein-induced pancreatitis in rats. Clin Sci 1994;87:85-90.
6. Shirasaki H, Nishikawa M, Adcock IM, et al. Expression of platelet-activating factor receptor mRNA in human and guinea pig lung. Am J Respir Cell Mol Biol 1994;10:533-7.
7. Spormann H, Sokolowski A, Letko G. Effect of temporary ischemia upon development and histological patterns of acute pancreatitis in the rat. Pathol Res Pract 1989;184:507-13.
8. Gross V, Leser HG, Heinisch A, Scholmerich J. Inflammatory mediators and cytokines: New aspects of the pathophysiology and assessment of severity of acute pancreatitis? Hepatogastroenterology 1993;40:522-30.
9. Schwartz JD, Shamamian P, Grossi EA, et al. Lexipafant inhibits platelet activating factor enhanced neutrophil functions. J Surg Res 1997;69:240-8.
10. Konturek SJ, Dembinski A, Konturek PJ, et al. Role of platelet-activating factor in pathogenesis of acute pancreatitis in rats. Gut 1992;33:1268-74.
11. Zhou W, McCollum MO, Levine BA, Olson MS. Role of platelet-activating factor in pancreatitis-associated acute lung injury in the rat. Am J Pathol 1992;140:971-9.
12. Kald B, Bald A, Ihse I, Tagesson C. Release of platelet-activating factor in acute experimental pancreatitis. Pancreas 1993; 8:440-2.
13. Ais G, Lopez-farre A, Gomez-Garre ND, et al. Role of platelet-activating factor in haemodynamic derangements in an acute rodent pancreatic model. Gastroenterology 1992;102:181-7.
14. Leonhardt U, Fayyazzi A, Seidensticker F, et al. Influence of a platelet-activating factor antagonist on severe pancreatitis in two experimental models. Int J Pancreatol 1992;12:161-6.
15. Emanuelli G, Montrucchio G, Dughera L, et al. Role of platelet activating factor in acute pancreatitis induced by lipopolysaccharides in rabbits. Eur J Pharmacol 1994;261:265-72.
16. Jaworek J, Konturek SJ. Effects of prostaglandin of E, F and I series, leukotriene C and platelet-activating factor on amylase release from isolated rat pancreatic acini. J Physiol Pharmacol 1993;44:365-81.
17. Suzuki S, Sugai K, Sato H, Arakawa M. Effect of platelet-activating factor antagonist, WEB 2086, on inhibition of active oxygen generation in human polymorphonuclear leukocytes. Pharmacology 1994;48:111-8.
18. 3H]SR 27417, a novel platelet-activating factor (PAF) receptor antagonist, to rabbit and human platelets and polymorphonuclear leukocytes. Biochem Pharmacol 1993;45:51-8.
19. Carolan EJ, Casale TB. Effects of nedocromil sodium and WEB 2086 on chemoattractant-stimulated neutrophil migration through cellular and noncellular barriers. Ann Allergy 1992;69: 323-8.
20. Kuipers B, Van der Poll T, Levi M, et al. Platelet-activating factor antagonists TCV-309 attenuates the induction of the cytokine network in experimental endotoxemia in chimpanzees. J Immunol 1994;152:2438-46.
21. Zehr KJ, Poston RS, Lee PC, et al. Platelet-activating factor inhibition reduces lung injury after cardiopulmonary bypass. Ann Thorac Surg 1995;59:328-35.
22. Dabrowski A, Gabrylelewicz A, Chyczewski L. Effect of platelet-activating factor antagonist (BN52021) on cerulin-induced acute pancreatitis with reference to oxygen radicals. Int J Pancreatol 1991;8:1-11.
23. Fujimura K, Kubota Y, Ogura M, et al. Role of endogenous platelet-activating factor in caerulin-induced pancreatitis in rats: Protective effects of PAF-antagonist. J Gastroenterol Hepatol 1992;7:199-202.
24. Tomazewska R, Dembinski A, Warzecha Z, et al. Platelet-activating factor (PAF) inhibitor (TCV-309) reduces caerulin- and PAF-induced pancreatitis: A morphologic and functional study in the rat. J Physiol Pharmacol 1992;4:345-52.
25. Summers JB, Albert DH. Platelet-activating factor antagonists. Adv Pharmacol 1995;32:67-168.
26. Rivera J, Werner J, Rattner DW, et al. Lexipafant fails to improve survival in severe necrotizing or hemorrhigic experimental pancreatitis. Pancreas 1996;13:454.
27. Trapnell JE. Pathophysiology of acute pancreatitis. World J Surg 1981;5:319-27.
28. Wulff K, Sjostrom B. Influence of acute pancreatitis on central hemodynamic, regional blood flow distribution and arteriovenous shunting in the dog. Eur Surg Res 1974;6:354-63.
29. Ryan CM, Schmidt J, Lewandrowski K, et al. Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats. Gastroenterology 1993;104:890-5.
30. Whittle BJR, Morishita T, Ohya Y, et al. Microvascular actions of platelet-activating factor on the rat gastric mucosa and submucosa. Am J Physiol 1986;251:G772-G778.
31. Travis SPL, Jewell DP. Regional differences in the response to platelet-activating factor in rabbit colon. Clin Sci 1992;82:673-80.
32. Kubes P, Arfors KE, Granger DN. Platelet-activating factor-induced mucosal dysfunction: Role of oxidants and granulocytes. Am J Physiol 1991;260:G965-G971.