New perspectives in the functional role of GABA(A) channel heterogeneity

Molecular Neurobiology

Volumn 19, Issue 2, 1999, Pages 97-110

  Vicini, Stefano ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Allosteric modulators; Benzodiazepines; Desensitization; GABA; GABA(A) receptor; Ion channels; IPSC; Patch clamp; Receptor subunits; Transfection

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; ION CHANNEL; NEUROSTEROID; PROTEIN SUBUNIT;

CEREBELLUM CORTEX; DESENSITIZATION; GRANULE CELL; INHIBITORY POSTSYNAPTIC POTENTIAL; MEMBRANE CURRENT; PATCH CLAMP; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PURKINJE CELL; REVIEW; STELLATE CELL; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION;

EID: 0032993736     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02743656     Document Type: Review

References (79)

1. Fagg, G. E. and Foster, A. C. (1983) Amino acid neurotransmitters and their pathways in the mammalian central nervous system. Neuroscience 26, 701-719.
2. Mody, I., De Koninck, Y., Otis, T. S., and Soltesz, I. (1994) Bridging the cleft at GABA synapses in the brain. Trends Neurosci. 17, 517-525.
3. A receptor channels. Ann. Rev. Neurosci. 17, 569-602.
4. A receptor research. Synapse 21, 189-274.
5. Jones, M. V. and Westbrook, G. L. (1996) The impact of receptor desensitization on fast synaptic transmission. Trends Neurosci. 19, 96-101.
6. Sigel, E., Stephenson, F. A., Mamalaki, C., and Barnard, E. A. (1983) A γ-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex. Purification and partial characterization. J. Biol. Chem. 258, 6965-6971.
7. A receptors. FASEB J. 4, 1469-1480.
8. A/benzodiazepine receptor heterogeneity: Neurophysiological implications. Neuropharmacology 34, 245-254.
9. A receptor subtypes. Int. Rev. Neurobiol 38, 95-139.
10. A receptor: Is there hope? J. Neurosci. Res. 41, 567-571.
11. A receptor determined by electron microscopic image analysis. J. Neurochem. 62, 815-818.
12. A receptor subunits. Science 242, 1306-1308.
13. Chen, C. and Okayama, H. (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7, 2745-2752.
14. A receptors depend upon subunit composition. Neuron 4, 919-928.
15. A receptor number underlie variation in GABA mini amplitude. Neuron 19, 697-709.
16. A receptor subunit. Nature 385, 820-823.
17. A receptors. J. Neurosci. 16, 6648-6656.
18. A receptor subunits: Role of the δ subunit. J. Neurosci. 14, 7077-7086.
19. Saxena, N. C. and Macdonald, R. L. (1996) Properties of putative cerebellar γ-aminobutyric acid (A) receptor isoforms. Mol. Pharmacol. 49, 567-579.
20. Saxena, N. C. and Macdonald, R. L. (1997) Contrasting actions of lanthanum on different recombinant γ-aminobutyric acid receptor isoforms expressed in L929 fibroblasts. Mol. Pharmacol. 51, 328-335.
21. A receptors. J. Pharmacol. Exp. Ther. 272, 438-445.
22. Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., and Paul, S. M. (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232, 1004-1007.
23. A receptor α6 subunit gene inactivation inhibits delta subunit expression. J. Neurosci. 17, 1350-1362.
24. A receptors from rat brain. Eur. J. Pharmacol. 290, 175-181.
25. Quirk, K., Gillard, N. P., Ragan, I., Whiting, P. J., and McKernan, R. M. (1994) Model of subunit composition of γ-aminobutyric acid receptor subtypes expressed in rat cerebellum with respect to their α and γ/δ subunits. J. Biol. Chem. 269, 16,020-16,028.
26. A receptor subtypes really occur in the brain. Trends Neurosci. 19, 139-143.
27. A receptor diversity. Neuropharmacology 35, 1139-1160.
28. Korpi E. R., Kuner, T., Seeburg, P. H., and Luddens, H. (1995) Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol. Pharmacol. 47, 283-289.
29. Ma, J. Y. and Narahashi, T. (1993) Enhancement of γ-aminobutyric acid activated chloride channel currents by lanthanum in rat dorsal root ganglion neurons. J. Neurosci. 13, 4872-4879.
30. A subunit mRNAs in the rat brain. I. Telencephanon, diencephalon, mesencephalon. J. Neurosci. 12, 1040-1062.
31. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci. 12, 1063-1076.
32. A receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J. Neurosci. 12, 4151-4172.
33. A receptor α5, α6 subunit-like immunoreactivity in rat brain. Neurosci. Lett. 144, 53-56.
34. Gao, B. and Fritschy, J. M. (1995) Cerebellar granule cells in vitro recapitulate the in vivo pattern of GABAA-receptor subunit expression. Dev. Brain Res. 88, 1-16.
35. A/benzodiazepine receptor complex in granule cells of the cerebellar cortex. Neuroscience 51, 739-748.
36. A receptors on cerebellar granule cells as determined by a quantitative immunogold method. J. Neurosci. 15, 2948-2960.
37. A receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. J. Neurosci. 16, 103-114.
38. Bovolin, P., Santi, M. R., Memo, M., Costa, E., and Grayson, D. R. (1992) Distinct developmental patterns of expression of rat α1, α5, γ2S, and γ2L γ-aminobutyric acidA receptor subunit mRNAs in vivo and in vitro. J. Neurochem. 59, 62-72.
39. A receptor occurs only after cerebellar granule cell migration. Dev. Brain Res. 75, 91-103.
40. A receptor subtypes containing the δ subunit in rat brain. FEBS Lett. 283, 145-149.
41. A receptor expression in Bergmann glial cells. J. Neurosci. 14, 2503-2514.
42. A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. Soc. Neurosci. Abs. 48.7 pp 101 Vol.23.
43. Edwards, F. A., Konnerth, A., and Sakmann, B. (1990) Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: A patch clamp study. J. Physiol. (Lond.) 430, 213-249.
44. A responses in hippocampus. Neuron 10, 189-200.
45. A receptors open? Neuron 12, 61-71.
46. - currents in Purkinje versus granule neurons in rat cerebellar slices. Neuron 12, 117-126.
47. A receptor channels. J. Neurophysiol. 71, 1318-1335.
48. A channels response to brief agonist pulses. Neuron 15, 181-191.
49. Jones, M. V. and Westbrook, G. L. (1997) Shaping of inhibitory postsynaptic currents by endogenous calcineurin activity. J. Neurosci. 17, 7626-7633.
50. A receptor α6 subunit. J. Neurosci. 16, 3630-3640.
51. A receptors. J. Physiol. 497, 753-759.
52. A receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons. J. Neurosci. 17, 7220-7227.
53. A receptors in cultured murine cerebellar granule cells. J. Physiol. (Lond.) 503, 353-369.
54. Hollrigel, G. S. and Soltesz, I. (1997) Slow kinetics of miniature IPSCs during early postnatal development in granule cells of the dentate gyrus. J. Neurosci. 17, 5119-5128.
55. - currents in rat thalamic reticular and relay neurons. J. Neurophysiol. 78, 2280-2266.
56. Jonas, P. and Spruston, N. (1994) Mechanisms shaping glutamate-medicated excitatory post-synaptic currents in the CNS. Curr. Opin. Neurobiol. 4, 366-372.
57. Verdoorn, T. A. (1994) Formation of heteromeric γ-aminobutyric acid type A receptor containing two different α subunits. Mol. Pharmacol. 25, 475-480.
58. A receptor gating kinetics on the alpha-subunit isoform: Implications for structure-function relations and synaptic transmission. J. Physiol. 489, 529-543.
59. A receptors. Neuropharmacology 35, 1375-1382.
60. Konnerth, A., Llano, I., and Armstrong, C. M. (1990) Synaptic currents in cerebellar Purkinje cells. Proc. Natl. Acad. Sci. USA 87, 2662-2665.
61. Vincent, P., Armstrong, C. M., and Marty, A. (1992) Inhibitory synaptic currents in rat cerebellar Purkinje cells: Modulation by postsynaptic depolarization. J. Physiol. (Lond.) 456, 453-471.
62. Llano, I. and Gerschenfeld, H. M. (1993) Inhibitory synaptic currents in stellate cells of rat cerebellar slices. J. Physiol. (Lond.) 468, 177-200.
63. Auger, C. and Marty, A. (1997) Heterogeneity of functional synaptic parameters among single release sites. Neuron 19, 139-150.
64. A receptors and glomerular geometry. Neuron 20, 783-795.
65. Vicini, S., Wroblewski, J. T., and Costa, E. (1986) Pharmacological modulation of GABAergic transmission in cultured cerebellar ceurons. Neuropharmacology 25, 207-211.
66. A receptor-mediated currents in granule cells of postnatal rat cerebellum. Eur. J. Neurosci. 9, 533-548.
67. A receptor. Nature 361, 356-359.
68. Homanics, G. E., Ferguson, C., Quinlan, J. J., Daggett, J., Snyder, K., Lagenaur, C., Mi, Z. P., Wang, X. H., Grayson, D. R., and Firestone, L. L. (1997) Gene knockout of the α6 subunit of the γ-aminobutyric acid type A receptor: Lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol. Pharmacol. 51, 588-596.
69. Kleingoor, C., Wieland, H. A., Korpi, E. R., Seeburg, P. H., and Kettenmann, H. (1993) Current potentiation by diazepam but not GABA sensitivity is determined by a single histidine residue. NeuroReports 4, 187-190.
70. Ueno, S., Zempel, J. M., and Steinbach, J. H. (1996) Differences in the expression of GABA(A) receptors between functionally innervated and non-innervated granule neurons in neonatal rat cerebellar cultures. Brain Res. 714, 49-56.
71. A receptor deactivation, desensitization and inhibitory synaptic currents in rat cerebellar neurons. J. Physiol. 5113, 647-661.
72. Yakel, J. L. (1997) Calcineurin regulation of synaptic function: From ion channels to transmitter release and gene transcription. Trends Pharmacol. Sci. 18, 124-134.
73. Segal, M., and Barker, J. L. (1984) Rat hippocampal neurons in culture: Voltage-clamp analysis of inhibitory connections. J. Neurophysiol. 52, 469-487.
74. Harrison, N. L., Vicini, S. and Barker, J. L. (1987) A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons. J. Neurosci. 7, 604-609.
75. Vicini, S., Alho, H., Costa, E., Mienville, J. M., Santi, M. R. and Vaccarino, F. M. (1986) Modulation of y-aminobutyric acid mediated inhibitory synaptic currents in dissociated cortical cell cultures. Proc. Natl. Acad. Sci. USA 83, 9269-9273.
76. Gyenes, M., Wang, Q., Gibbs, T. T. and Farb, D. H. (1994) Phosphorylation factors control neurotransmitter and neuromodulator actions at the gamma-aminobutyric acid type A receptor. Mol. Pharmacol. 46, 542-549.
77. A channel deactivation by altering kinetics of desensitized states. J. Neurosci. 17, 4022-4031.
78. A synapses during flurazepam withdrawal are region-specific in the hippocampal formation. J. Neurosci. 17, 3467-3475.
79. A receptor regulation: Heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture. Brain Res. 707, 100-109.