Clonidine inhibits and phorbol acetate activates glutamate release from rat spinal synaptoneurosomes

Anesthesia and Analgesia

Volumn 88, Issue 6, 1999, Pages 1401-1405

  Shinomura, Tetsutaro ^a   Nakao, Shin Ichi ^b   Adachi, Takehiko ^a   Shingu, Koh ^b  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; CLONIDINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUTAMIC ACID; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; POTASSIUM CHLORIDE; PROTEIN KINASE C;

ANALGESIC ACTIVITY; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; MALE; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SYNAPTOSOME;

EID: 0032991304     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199906000-00037     Document Type: Article

References (24)

1. Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 1990;13: 171-82.
2. Hyman SE. Addiction to cocaine and amphetamine. Neuron 1996;16:901-4.
3. Hunter JC, Singh L. Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat. Neurosci Lett 1994;174:217-21.
4. Coderre TJ. The role of excitatory amino acid receptors and intracellular messengers in persistent nociception after tissue injury in rats. Mol Neurobiol 1993;7:229-46.
5. Zhuo M, Gebhart GF. Spinal cholinergic and monoaminergic receptors mediate descending inhibition from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Brain Res 1990;535:67-78.
6. Frenk H, Bossut D, Urca G, Mayer DJ. Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from intrathecal administration of substance P and 6 excitatory compounds. Brain Res 1988;455: 223-31.
7. Seltzer Z, Cohn S, Ginzburg R, Beilin B. Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge. Pain 1991;45:69-75.
8. Bossut D, Frenk H, Mayer DJ. Is substance P a primary afferent neurotransmitter for nociceptive input? II. Spinalization does not reduce and intrathecal morphine potentiates behavioral responses to substance P. Brain Res 1988;455:232-9.
9. Maze M, Tranquilli W. Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology 1991;74:581-605.
10. Ono H, Mishima A, Ono S, et al. Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists. Neuropharmacology 1991;30:585-9.
11. Holz GG IV, Kream RM, Spiegel A, Dunlap K. G proteins couple alpha-adrenergic and GABAb receptors to inhibition of peptide secretion from peripheral sensory neurons. J Neurosci 1989;9: 657-66.
12. Omote K, Kitahata LM, Collins JG, et al. Interaction between opiate subtype and alpha-2 adrenergic agonists in suppression of noxiously evoked activity of WDR neurons in the spinal dorsal horn. Anesthesiology 1991;74:737-43.
13. Malmberg AB, Chen C, Tonegawa S, Basbaum AI. Preserved acute pain and reduced neuropathic pain in mice lacking PKC-gamma. Science 1997;278:279-83.
14. Hollingsworth EB, McNeal ET, Burton JL, et al. Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3′:5′-monophosphate-generating systems, receptors, and enzymes. J Neurosci 1985;5:2240-53.
15. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
16. Barrie AP, Nicholls DG, Sanchez Prieto J, Sihra TS. An ion channel locus for the protein kinase C potentiation of transmitter glutamate release from guinea pig cerebrocortical synaptosomes. J Neurochem 1991;57:1398-404.
17. Schlame M, Hemmings HC Jr. Inhibition by volatile anesthetics of endogenous glutamate release from synaptosomes by a presynaptic mechanism. Anesthesiology 1995;82:1406-16.
18. Shinomura T, Nakao S, Mori K. Reduction of depolarization-induced glutamate release by heme oxygenase inhibitor: possible role of carbon monoxide in synaptic transmission. Neurosci Lett 1994;166:131-4.
19. Bonanno G, Vallebuona F, Donadini F, et al. Heterocarrier-mediated reciprocal modulation of glutamate and glycine release in rat cerebral cortex and spinal cord synaptosomes. Eur J Pharmacol 1994;252:61-7.
20. Kamisaki Y, Hamada T, Maeda K, et al. Presynaptic alpha 2 adrenoceptors inhibit glutamate release from rat spinal cord synaptosomes. J Neurochem 1993;60:522-6.
21. 2+ and glutamate release. J Neurochem 1989;53:1693-9.
22. Nicholls DG. The glutamatergic nerve terminal. Eur J Biochem 1993;212:613-31.
23. Eisenach J, Detweiler D, Hood D. Hemodynamic and analgesic actions of epidurally administered clonidine. Anesthesiology 1993;78:277-87.
24. Cerne R, Jiang M, Randic M. Cyclic adenosine 3′5′-monophosphate potentiates excitatory amino acid and synaptic responses of rat spinal dorsal horn neurons. Brain Res 1992;596: 111-23.