Synthesis of a C-8 modified adenosine analogue as a potential mechanistic probe for ribonucleotide reductases

Nucleosides and Nucleotides

Volumn 18, Issue 4-5, 1999, Pages 611-612

  Magnin, G C ^a   Dauvergne, J ^a   Burger, A ^a   Biellmann, J F ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DERIVATIVE; RIBONUCLEOTIDE REDUCTASE; VINYL DERIVATIVE;

CONFERENCE PAPER; ENZYME BINDING; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

EID: 0032990369     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/15257779908041513     Document Type: Conference Paper

References (8)

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2. Roy, B.; Lepoivre, M.; Decout, J. L.; Lhomme, J.; Fontecave, M. Biochem. Biophys. Res. Commun., 1992, 187, 432-437.
3. Eriksson, M.; Uhlin, U.; Ramaswamy, S.; Ekberg, M., Regnström, K.; Sjöberg, B.-M.; Eklund, H. Structure, 1997, 5, 1077-1092.
4. Robins, M. J.; Wilson, J. S.; Hansske, F. J. Am. Chem. Soc., 1983, 105, 4059-4065.
5. Moriarty, R. M.; Epa, W. R.; Awasthi, A. K. Tetrahedron Lett., 1990, 31, 5877-5880.
6. For other examples of endoproduct formation, see : Curran, D. P. in Comprehensive Organic Synthesis, Trost, B. M.; Flemming, I.; Ed. : Pergamon Press, Oxford, 1991, vol. 4, pp. 779-831.
7. Usui, H.; Ueda, T. Chem. Pharm. Bull., 1986, 34, 15-23.
8. Addition of the glycosylic radical on the vinyl group may account for the biological activity observed for 8-vinyladenosine, see : Manfredini, S.; Baraldi, P. G.; Bazzanini, R.; Marangoni, M.; Simoni, D.; Balzarini, J.; De Clercq, E. J. Med. Chem., 1995, 38, 199-203.