메뉴 건너뛰기




Volumn 11, Issue 2, 1999, Pages 115-123

Pharmacokinetics of the recombinant thrombolytic agents: What is the clinical significance of their different pharmacokinetic parameters?

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; FIBRINOLYTIC AGENT; RECOMBINANT PROTEIN; RETEPLASE; SARUPLASE; STREPTOKINASE; UROKINASE;

EID: 0032989947     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-199911020-00005     Document Type: Review
Times cited : (14)

References (43)
  • 1
    • 0018631085 scopus 로고
    • Streptokinase in acute myocardial infarction
    • European Cooperative study group for streptokinase treatment in acute myocardial infarction. Streptokinase in acute myocardial infarction. N Engl J Med 1979; 301: 797-802
    • (1979) N Engl J Med , vol.301 , pp. 797-802
  • 2
    • 0021923571 scopus 로고
    • The Western Washington randomised trial of intracoronary streptokinase in acute myocardial infarction
    • Kennedy JW, Ritchie JL, Davis KB, et al. The Western Washington randomised trial of intracoronary streptokinase in acute myocardial infarction. N Engl J Med 1985; 312: 1073-8
    • (1985) N Engl J Med , vol.312 , pp. 1073-1078
    • Kennedy, J.W.1    Ritchie, J.L.2    Davis, K.B.3
  • 3
    • 0026607185 scopus 로고
    • ISIS-3: A randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41299 cases of suspected acute myocardial infarction
    • ISIS-3. ISIS-3: a randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41299 cases of suspected acute myocardial infarction. Lancet 1992; 339: 753-70
    • (1992) Lancet , vol.339 , pp. 753-770
  • 4
    • 0027240597 scopus 로고
    • An international randomised trial comparing four thrombolytic strategies for acute myocardial infarction
    • GUSTO Investigators. An international randomised trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 1993; 329: 673-82
    • (1993) N Engl J Med , vol.329 , pp. 673-682
  • 5
    • 0026582573 scopus 로고
    • Front-loaded accelerated infusions of tissue plasminogen activator: Putting a better foot forward
    • Vaughan DE, Braunwald E. Front-loaded accelerated infusions of tissue plasminogen activator: putting a better foot forward [editorial; comment]. J Am Coll Cardiol 1992; 19 (5): 1076-8
    • (1992) J Am Coll Cardiol , vol.19 , Issue.5 , pp. 1076-1078
    • Vaughan, D.E.1    Braunwald, E.2
  • 6
    • 0026520542 scopus 로고
    • Pharmacokinetics and fibrin specificity of alteplase during accelerated infusions in acute
    • Tanswell P. Tebbe U, Neuhaus KL, et al. Pharmacokinetics and fibrin specificity of alteplase during accelerated infusions in acute. J Am Coll Cardiol 1992; 19 (5): 1071-5
    • (1992) J Am Coll Cardiol , vol.19 , Issue.5 , pp. 1071-1075
    • Tanswell, P.1    Tebbe, U.2    Neuhaus, K.L.3
  • 7
    • 0030847845 scopus 로고    scopus 로고
    • A comparison of continuous infusion of alteplasc with double-bolus administration for acute myocardial infarction
    • The Continuous infusion versus double-bolus administration of alteplase (COBALT) investigators. A comparison of continuous infusion of alteplasc with double-bolus administration for acute myocardial infarction. N Engl J Med 1997; 337 (16): 1124-30
    • (1997) N Engl J Med , vol.337 , Issue.16 , pp. 1124-1130
  • 9
    • 0023122647 scopus 로고
    • A kinetic analysis of fibrinogenolysis during plasminogen activator therapy
    • Noe DA, Bell WR. A kinetic analysis of fibrinogenolysis during plasminogen activator therapy. Clin Pharmacol Ther 1987; 41: 297-303
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 297-303
    • Noe, D.A.1    Bell, W.R.2
  • 10
    • 0022447699 scopus 로고
    • Pharmacodynamics of tissue-type plasminogen activator characterised by computer-assisted simulation
    • Tiefenbrunn AJ, Graor RA, Robison AK, et al. Pharmacodynamics of tissue-type plasminogen activator characterised by computer-assisted simulation. Circulation 1986; 73: 1291-9
    • (1986) Circulation , vol.73 , pp. 1291-1299
    • Tiefenbrunn, A.J.1    Graor, R.A.2    Robison, A.K.3
  • 11
    • 0027057301 scopus 로고
    • Bolus application of a novel recombinant plasminogen activator in acute myocardial infarction
    • Seifried E, Muller MM, Martin U, et al. Bolus application of a novel recombinant plasminogen activator in acute myocardial infarction. Ann N Y Acad Sci 1992; 667: 417-20
    • (1992) Ann N Y Acad Sci , vol.667 , pp. 417-420
    • Seifried, E.1    Muller, M.M.2    Martin, U.3
  • 12
    • 0026047886 scopus 로고
    • Dose-ranging study of the novel recombinant plasminogen activator BM 06.022 in healthy volunteers
    • Martin U, Mollendorfr EV, Akpan W, et al. Dose-ranging study of the novel recombinant plasminogen activator BM 06.022 in healthy volunteers. Clin Pharmacol Ther 1991; 50: 429-36
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 429-436
    • Martin, U.1    Mollendorfr, E.V.2    Akpan, W.3
  • 13
    • 0026012337 scopus 로고
    • Pharmacokinetic and hemostatic properties of the recombinant plasminogen activator BM 06.022 in healthy volunteers
    • Martin A, Mollendorff EV, Akpan W, et al. Pharmacokinetic and hemostatic properties of the recombinant plasminogen activator BM 06.022 in healthy volunteers. Thromb Haemostasis 1991; 66 (5): 569-74
    • (1991) Thromb Haemostasis , vol.66 , Issue.5 , pp. 569-574
    • Martin, A.1    Mollendorff, E.V.2    Akpan, W.3
  • 14
    • 0024353147 scopus 로고
    • Pharmacokinetics and haemostatic status during consecutive infusions of recombinant tissue-type plasminogen activator in patients with acute myocardial infarction
    • Seifried E, Tanswell P, Ellbruck D, et al. Pharmacokinetics and haemostatic status during consecutive infusions of recombinant tissue-type plasminogen activator in patients with acute myocardial infarction. Thromb Haemost 1989; 61 (3): 497-501
    • (1989) Thromb Haemost , vol.61 , Issue.3 , pp. 497-501
    • Seifried, E.1    Tanswell, P.2    Ellbruck, D.3
  • 15
    • 0024455871 scopus 로고
    • Pharmacokinetics and systemic effects of tissue-type plasminogen activator in normal subjects
    • Tanswell P, Seifried E, Su PC, et al. Pharmacokinetics and systemic effects of tissue-type plasminogen activator in normal subjects. Clin Pharmacol Ther 1989; 46: 155-62
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 155-162
    • Tanswell, P.1    Seifried, E.2    Su, P.C.3
  • 16
    • 0024387115 scopus 로고
    • Single-bolus injection of recombinant tissue-type plasminogen activator in acute myocardial infarction
    • Tebbe U, Tanswell P, Seifried E, et al. Single-bolus injection of recombinant tissue-type plasminogen activator in acute myocardial infarction. Am J Cardiol 1989; 64: 448-53
    • (1989) Am J Cardiol , vol.64 , pp. 448-453
    • Tebbe, U.1    Tanswell, P.2    Seifried, E.3
  • 17
    • 0023880353 scopus 로고
    • Pharmacokinetics of antigen and activity of recombinant tissue-type plasminogen activator after infusion in healthy volunteers
    • Seifried E, Tanswell P, Rijken DC, et al. Pharmacokinetics of antigen and activity of recombinant tissue-type plasminogen activator after infusion in healthy volunteers. Arzneimittelforschung 1988; 38: 418-22
    • (1988) Arzneimittelforschung , vol.38 , pp. 418-422
    • Seifried, E.1    Tanswell, P.2    Rijken, D.C.3
  • 18
    • 0026008827 scopus 로고
    • The pharmacokinetics of recombinant double chain t-PA (Duteplase): Effects of bolus injection, infusions and administration by weight in patients with myocardial infarction
    • Koster RW, Cohen AF, Kluft C, et al. The pharmacokinetics of recombinant double chain t-PA (Duteplase): Effects of bolus injection, infusions and administration by weight in patients with myocardial infarction. Clin Pharmacol Ther 1991; 50: 267-77
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 267-277
    • Koster, R.W.1    Cohen, A.F.2    Kluft, C.3
  • 19
    • 0028092194 scopus 로고
    • Pharmacokinetics and pharmacodynamics of saruplase, an unglycosylated single-chain urokinase-type plasminogen activator, in patients with acute myocardial infarction
    • Koster RW, Cohen AF, Hopkins G, et al. Pharmacokinetics and pharmacodynamics of saruplase, an unglycosylated single-chain urokinase-type plasminogen activator, in patients with acute myocardial infarction. Thromb Haemost 1994; 71 (5): 740-4
    • (1994) Thromb Haemost , vol.71 , Issue.5 , pp. 740-744
    • Koster, R.W.1    Cohen, A.F.2    Hopkins, G.3
  • 20
    • 0028946552 scopus 로고
    • Effects ofchanging liver blood flow by exercise and food on kinetics and dynamics of saruplase
    • Griensven JMTv, Burggraaf J, Gerloff J, et al. Effects ofchanging liver blood flow by exercise and food on kinetics and dynamics of saruplase. Clin Pharmacol Ther 1995; 57: 381-9
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 381-389
    • Griensven, J.M.T.V.1    Burggraaf, J.2    Gerloff, J.3
  • 21
    • 0027008773 scopus 로고
    • Clearance of plasminogen activators - A major determinant of plasma concentration. Therapeutic and diagnostic implications
    • Cohen AF, Burggraaf J, Boer AD, et al. Clearance of plasminogen activators - a major determinant of plasma concentration. Therapeutic and diagnostic implications. Ann N Y Acad Sci 1992; 667: 443-9
    • (1992) Ann N Y Acad Sci , vol.667 , pp. 443-449
    • Cohen, A.F.1    Burggraaf, J.2    Boer, A.D.3
  • 22
    • 0029801342 scopus 로고    scopus 로고
    • Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue-type plasminogen activator
    • Griensven JMTv, Huisman L, Stuurman T, et al. Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue-type plasminogen activator. Clin Pharmacol Ther 1996; 60: 504-11
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 504-511
    • Griensven, J.M.T.V.1    Huisman, L.2    Stuurman, T.3
  • 23
    • 0026569339 scopus 로고
    • Liver blood flow as a major determinant of the clearance of recombinant tissue-type plasminogen activator
    • Boer AD, Kluft C, Kroon JM, et al. Liver blood flow as a major determinant of the clearance of recombinant tissue-type plasminogen activator. Thromb Haemost 1992; 67: 83-7
    • (1992) Thromb Haemost , vol.67 , pp. 83-87
    • Boer, A.D.1    Kluft, C.2    Kroon, J.M.3
  • 24
    • 0031893503 scopus 로고    scopus 로고
    • Effects of liver blood flow on the pharmacokinetics of tissue type plasminogen activator (alteplase) during thrombolysis in patients with acute myocardial infarction
    • Griensven JMTv, Koster RW, Burggraaf J. et al. Effects of liver blood flow on the pharmacokinetics of tissue type plasminogen activator (alteplase) during thrombolysis in patients with acute myocardial infarction. Clin Pharmacol Ther 1998; 63: 39-47
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 39-47
    • Griensven, J.M.T.V.1    Koster, R.W.2    Burggraaf, J.3
  • 25
    • 0030765101 scopus 로고    scopus 로고
    • Effect of changes in liver blood flow on the pharmacokinetics of saruplase in patients with acute myocardial infarction
    • Griensven JMTV, Koster RW, Hopkins G, et al. Effect of changes in liver blood flow on the pharmacokinetics of saruplase in patients with acute myocardial infarction. Thromb Haemost 1997; 78 (3): 1015-20
    • (1997) Thromb Haemost , vol.78 , Issue.3 , pp. 1015-1020
    • Griensven, J.M.T.V.1    Koster, R.W.2    Hopkins, G.3
  • 26
    • 0029560188 scopus 로고
    • Uptake, internalisation and degradation of the novel plasminogen activator reteplase (BM 06.022)
    • Kuiper J, van de Bilt H, Martin U, et al. Uptake, internalisation and degradation of the novel plasminogen activator reteplase (BM 06.022). Thromb Haemost 1995; 74 (6): 1501-10
    • (1995) Thromb Haemost , vol.74 , Issue.6 , pp. 1501-1510
    • Kuiper, J.1    Van De Bilt, H.2    Martin, U.3
  • 27
    • 0029874648 scopus 로고    scopus 로고
    • Influence of the degree of renal dysfunction on the pharmacokinetic properties of the novel recombinant plasminogen activator reteplase in rats
    • Martin U, Doerge L, Stegmeier K, et al. Influence of the degree of renal dysfunction on the pharmacokinetic properties of the novel recombinant plasminogen activator reteplase in rats. Drug Memb Dispos 1996; 24 (3): 288-92
    • (1996) Drug Memb Dispos , vol.24 , Issue.3 , pp. 288-292
    • Martin, U.1    Doerge, L.2    Stegmeier, K.3
  • 28
    • 0022272666 scopus 로고
    • The thrombolytic and haemorrhagic effects of tissue type plasminogen activator: Influence of dosage regimens in rabbits
    • Agnelli G, Buchanan MR, Fernandez F, et al. The thrombolytic and haemorrhagic effects of tissue type plasminogen activator: Influence of dosage regimens in rabbits. Thromb Res 1985; 40: 769-77
    • (1985) Thromb Res , vol.40 , pp. 769-777
    • Agnelli, G.1    Buchanan, M.R.2    Fernandez, F.3
  • 29
    • 0025029927 scopus 로고
    • A randomised dose-ranging study of rt-PA in acute myocardial infarction. Effects on coronary patency and fibrinolytic parameters
    • Koster RW, Stralen van R, McNeill AJ, et al. A randomised dose-ranging study of rt-PA in acute myocardial infarction. Effects on coronary patency and fibrinolytic parameters. Eur Heart J 1990; 11: 730-9
    • (1990) Eur Heart J , vol.11 , pp. 730-739
    • Koster, R.W.1    Van Stralen, R.2    McNeill, A.J.3
  • 30
    • 0023840376 scopus 로고
    • Pharmacokinetics and thrombolytic properties of deletion mutants of human tissue-type plasminogen activator in rabbits
    • Collen D, Stassen JM, Larsen G. Pharmacokinetics and thrombolytic properties of deletion mutants of human tissue-type plasminogen activator in rabbits. Blood 1988; 71 (1): 216-9
    • (1988) Blood , vol.71 , Issue.1 , pp. 216-219
    • Collen, D.1    Stassen, J.M.2    Larsen, G.3
  • 31
    • 0029826062 scopus 로고    scopus 로고
    • Reteplase. A review of its pharmacological properties and clinical efficacy in the management of acute myocardial infarction
    • Noble S, McTavish D. Reteplase. A review of its pharmacological properties and clinical efficacy in the management of acute myocardial infarction. Drugs 1996; 52 (4): 589-605
    • (1996) Drugs , vol.52 , Issue.4 , pp. 589-605
    • Noble, S.1    McTavish, D.2
  • 32
    • 0030893793 scopus 로고    scopus 로고
    • Aspirin, heparin and fibrinolytic therapy in suspected acute myocardial infarction
    • Collins R, Peto R, Baigent C, et al. Aspirin, heparin and fibrinolytic therapy in suspected acute myocardial infarction. N Engl J Med 1997; 336 (12): 847-60
    • (1997) N Engl J Med , vol.336 , Issue.12 , pp. 847-860
    • Collins, R.1    Peto, R.2    Baigent, C.3
  • 33
    • 0023258694 scopus 로고
    • Thrombolysis in myocardial infarction (TIMI) trial, phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase
    • Chesebro JH, Knatterud GL, Roberts R, et al. Thrombolysis in myocardial infarction (TIMI) trial, phase I: a comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Circulation 1987; 76: 142-54
    • (1987) Circulation , vol.76 , pp. 142-154
    • Chesebro, J.H.1    Knatterud, G.L.2    Roberts, R.3
  • 34
    • 0022635358 scopus 로고
    • Acute coronary reocclusion after thrombolysis with recombinant human tissue-type plasminogen activator: Prevention by a maintenance infusion
    • Gold HK, Leinbach RC, Garabedian HD, et al. Acute coronary reocclusion after thrombolysis with recombinant human tissue-type plasminogen activator: prevention by a maintenance infusion. Circulation 1986; 73: 347-52
    • (1986) Circulation , vol.73 , pp. 347-352
    • Gold, H.K.1    Leinbach, R.C.2    Garabedian, H.D.3
  • 35
    • 0023293013 scopus 로고
    • Announcement of protocol change in thrombolysis in myocardial infarction trial
    • Braunwald E, Knatterud GL, Passamani ER, et al. Announcement of protocol change in thrombolysis in myocardial infarction trial [letter]. J Am Coll Cardiol 1987; 9 (2): 467
    • (1987) J Am Coll Cardiol , vol.9 , Issue.2 , pp. 467
    • Braunwald, E.1    Knatterud, G.L.2    Passamani, E.R.3
  • 36
    • 0028092194 scopus 로고
    • Pharmacokinetics and pharmacodynamics of saruplase, an unglycosylated single-chain
    • Koster RW, Cohen AF, Hopkins GR, et al. Pharmacokinetics and pharmacodynamics of saruplase, an unglycosylated single-chain. Thromb Haemost 1994; 72 (5): 740-4
    • (1994) Thromb Haemost , vol.72 , Issue.5 , pp. 740-744
    • Koster, R.W.1    Cohen, A.F.2    Hopkins, G.R.3
  • 37
    • 0021742748 scopus 로고
    • Coronary thrombolysis with recombinant human tissue-type plasminogen activator: A prospective, randomised, placebo-controlled trial
    • Collen D, Topoi EJ, Tiefenbrunn AJ, et al. Coronary thrombolysis with recombinant human tissue-type plasminogen activator: a prospective, randomised, placebo-controlled trial. Circulation 1984; 70: 1012-7
    • (1984) Circulation , vol.70 , pp. 1012-1017
    • Collen, D.1    Topoi, E.J.2    Tiefenbrunn, A.J.3
  • 38
    • 0022655051 scopus 로고
    • Intravenous recombinant tissue-type plasminogen activator in patients with acute myocardial infarction: A report from the NHLBI thrombolysis in myocardial infarction trial
    • Williams DO, Borer J, Braunwald E, et al. Intravenous recombinant tissue-type plasminogen activator in patients with acute myocardial infarction: a report from the NHLBI thrombolysis in myocardial infarction trial. Circulation 1986; 73: 338-46
    • (1986) Circulation , vol.73 , pp. 338-346
    • Williams, D.O.1    Borer, J.2    Braunwald, E.3
  • 39
    • 0030814329 scopus 로고    scopus 로고
    • Equivalence trials
    • Ware JH, Antman EM. Equivalence trials. N Engl J Med 1997; 337 (16): 1159-61
    • (1997) N Engl J Med , vol.337 , Issue.16 , pp. 1159-1161
    • Ware, J.H.1    Antman, E.M.2
  • 40
    • 0029142436 scopus 로고
    • Randomised, double-blind comparison of reteplase double-bolus administration with streptokinase in acute myocardial infarction (INJECT): Trial to investigate equivalence
    • Hampton JR, Schröder R, Wilcox RG. Randomised, double-blind comparison of reteplase double-bolus administration with streptokinase in acute myocardial infarction (INJECT): trial to investigate equivalence. Lancet 1995; 346 (8971): 329-36
    • (1995) Lancet , vol.346 , Issue.8971 , pp. 329-336
    • Hampton, J.R.1    Schröder, R.2    Wilcox, R.G.3
  • 41
    • 0028214808 scopus 로고
    • Differences in clot lysis among patients demonstrated in vitro with three thrombolytic agents (tissue type plasminogen activator, streptokinase and urokinase)
    • Musselman DR, Tate DA, Oberhardt BJ, et al. Differences in clot lysis among patients demonstrated in vitro with three thrombolytic agents (tissue type plasminogen activator, streptokinase and urokinase). Am J Cardiol 1994; 73: 544-9
    • (1994) Am J Cardiol , vol.73 , pp. 544-549
    • Musselman, D.R.1    Tate, D.A.2    Oberhardt, B.J.3
  • 42
    • 0029839379 scopus 로고    scopus 로고
    • Estimating impossible curves using NONMEM
    • Schoemaker HC, Cohen AF. Estimating impossible curves using NONMEM. Br J Clin Pharmacol 1996; 42: 283-90
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 283-290
    • Schoemaker, H.C.1    Cohen, A.F.2
  • 43
    • 16944362757 scopus 로고    scopus 로고
    • TNK-tissue plasminogen activator in acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI) 10A dose-ranging trial
    • Cannon CP, McCabe CH, Gibson CM, et al. TNK-tissue plasminogen activator in acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI) 10A dose-ranging trial. Circulation 1997; 95 (2): 351-6
    • (1997) Circulation , vol.95 , Issue.2 , pp. 351-356
    • Cannon, C.P.1    McCabe, C.H.2    Gibson, C.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.