Stereoselective and endothelium-independent action of nicardipine on the isolated porcine coronary artery

European Journal of Pharmacology

Volumn 369, Issue 1, 1999, Pages 43-47

  Japelj, Irena ^a   Budihna, Metka V ^a   Stanovnik, Lovro ^a   Krisch, Igor ^b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b R D LEK Pharmaceutical Chem V   (Slovenia)

Author keywords

Ca2+ channel antagonist; Coronary artery, pig; Nicardipine; Stereoisomerism

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; NICARDIPINE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY CONSTRICTION; ENANTIOMER; ISOLATED ARTERY; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOISOMERISM; SWINE; VASCULAR ENDOTHELIUM;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; MUSCLE CONTRACTION; NICARDIPINE; POTASSIUM CHLORIDE; STEREOISOMERISM; SWINE; VASOCONSTRICTION;

EID: 0032989349     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00049-7     Document Type: Article

References (21)

1. Bechem M., Schramm M. Calcium antagonists. J. Mol. Cell. Cardiol. 19:1987;63-75. Suppl. II.
2. Bolton T.B. Mechanisms of action of transmitters and other substances on smooth muscle. Physiol. Rev. 59:1979;606-718.
3. Brisac A.M., Champéroux P., Lucet B., Laurent S., Schmitt H. Central and peripheral hypotensive effects of the optical isomers of nicardipine, a dihydropyridine calcium channel antagonists, in rats. Eur. J. Pharmacol. 146:1988;171-174.
4. Dhein S., Zhao Y., Simsek S., Salameh A., Klaus W. Actions of 1,4-dihydropyridines in isolated mesenteric vascular beds. J. Cardiovasc. Pharmacol. 26:1995;784-791.
5. Ferro C., Webb D.J. Endothelial dysfunction and hypertension. Drugs. 53:1997;30-41. Suppl. 1.
6. Gjörstrup P., Harding H., Isaksson R., Westerlund C. The enantiomers of the dihydropyridine derivative H 160/51 show opposite effects of stimulation and inhibition. Eur. J. Pharmacol. 122:1986;357-361.
7. Günther J., Dhein R., Rösen R., Klaus W., Fricke U. Nitric oxide (EDRF) enhances the vasorelaxing effect of nitrendipine in various isolated arteries. Basic Res. Cardiol. 87:1992;452-460.
8. Himmel H.M., Whorton A.R., Strauss H.C. Intracellular calcium, currents and stimulus-response coupling in endothelial cells. Hypertension. 21:1993;112-127.
9. Hof R.P., Rüegg U.T., Hof A., Vogel A. Stereoselectivity at the calcium channel: opposite action of the enantiomers of a 1,4-dihydropyridine. J. Cardiovasc. Pharmacol. 7:1985;689-693.
10. Hof R.P., Hof A., Rüegg U.T., Cook N.S., Vogel A. Stereoselectivity at the calcium channel: different profiles of hemodynamic activity of the enantiomers of the dihydropyridine derivative PN 200-110. J. Cardiovasc. Pharmacol. 8:1986;221-226.
11. Hussain T., Mustafa S.J. An in vitro pharmacological model of vascular smooth muscle. J. Pharmacol. Toxicol. Methods. 30:1993;111-115.
12. Iwatsuki K., Iijima F., Chiba S. Secretory and vascular effects of the optical isomers of nicardipine. Clin. Exp. Pharmacol. 11:1984;1-5.
13. 2α precontracted porcine isolated arteries after pretreatment with methylene blue. Basic Res. Cardiol. 85:1990;461-666.
14. 2α and some dihydropyridine-type calcium antagonists in porcine basilar arteries. Basic Res. Cardiol. 86:1991;254-265.
15. Matsumoto T., Kinoshita M., Toda N. Mechanisms of endothelium-dependent responses to vasoactive agents in isolated porcine coronary arteries. J. Cardiovasc. Pharmacol. 22:1993;228-234.
16. Mügge A., Peterson T., Harrison D. Release of nitrogen oxide from cultured bovine aortic endothelial cells is not impaired by calcium channel antagonists. Circulation. 83:1991;1404-1409.
17. Rubanyi G.M., Hoeffner U., Schwartz A., Vanhoutte P.M. Stereoselective effect of diltiazem on endothelium-dependent relaxations in canine femoral arteries. J. Pharmacol. Exp. Ther. 246:1988;60-64.
18. Salameh A., Schomecker G., Breitkopf K., Dhein S., Klaus W. The effects of the calcium-antagonist nitrendipine on intracellular calcium concentration in endothelial cells. Br. J. Pharmacol. 118:1996;1899-1904.
19. Spedding M., Schihi V., Schoeffter P., Miller R.C. Calcium channel activation does not increase release of endothelial-derived relaxant factors (EDRF) in rat aorta although tonic release of EDRF may modulate calcium channel activity in smooth muscle. J. Cardiovasc. Pharmacol. 8:1986;1130-1137.
20. 2+-antagonist. Jpn. J. Pharmacol. 32:1982;665-670.
21. Towart R., Wehinger E., Meyer H., Kazda S. The effects of nimodipine, its optical isomers and metabolites on the isolated vascular smooth muscle. Arzneim.-Forsch. 32:1982;338-346.