Pharmacokinetics and metabolism of ketoprofen after intravenous and intramuscular administration in camels

Journal of Veterinary Pharmacology and Therapeutics

Volumn 22, Issue 2, 1999, Pages 127-135

  Alkatheeri, N A ^a   Wasfi, Ibrahim A ^a   Lambert, M ^b  

^a Forensic Science Laboratory Abu Dhabi   (United Arab Emirates)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

KETOPROFEN;

ANIMAL EXPERIMENT; ARTICLE; CAMEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; FEMALE; GAS CHROMATOGRAPHY; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY CLEARANCE; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BLOOD PROTEINS; CAMELS; DOPING IN SPORTS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HALF-LIFE; HYDROLYSIS; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; KETOPROFEN; MALE; PROTEIN BINDING;

ANIMALIA; CAMELIDAE; CAMELUS DROMEDARIUS;

EID: 0032988558     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1999.00193.x     Document Type: Article

References (35)

1. Ali, B.H. (1988) A survey of some drugs commonly used in the camel. Veterinary Research Communications, 12, 67-75.
2. DeGraves, F.J., Riddell, M.G. & Schumacher, J. (1996) Ketoprofen Concentration in Plasma and Milk After Intravenous Administration in Dairy Cattle. American Journal of Veterinary Research, 57, 1031-1033.
3. Delbarre, F., Roucayrol, J.C., Amor, B., Ingrand, J., Boural, G., Fournel, J. & Courjaret, J. (1976) Pharmacokinetic study of ketoprofen (19.583 R. P.) in man using the tritiated compound. Scandinavian Journal of Rheumatology, (Suppl. 197) 6, 45-52.
4. Fenwick, D.C. & Daniel, R.A. (1996) Evaluation of the effect of Ketoprofen on Experimentally Induced Ephemeral Fever in Diary Heifers. Australian Veterinary Journal, 74, 37-41.
5. Flouvat, B., Roux, A. & Delhotal-Landes, B. (1989) Pharmacokinetics of ketoprofen in man after repeated percutaneons administration. Arzneimittelforschung, 39, 812-815.
6. Gibaldi, M. & Perrier, D. (1982) Non compartmental analysis based on statistical moment theory. In Pharmacokinetics. Ed. Dekker, M. pp. 133-178. Plenum Press, New York.
7. Glew, A., Aviad, A.D., Keister, D.M. & Meo, N.J. (1996) Use of ketoprofen as an antipyretic in cats. Canadian Veterinary Journal, 37, 222-225.
8. Grubb, N.G., Rudy, D.W. & Hall, S.D. (1996) Stereoselective high-performance liquid chromatographic analysis of ketoprofen and its acyl glucuronides in chronic renal insufficiency. Journal of Chromatography B, 678, 237-244.
9. Hurault de Ligny, B., Debruyne, D., Ryckelynck, J.P., Levaltier, B., Albessard, F. & Moulin, M. (1989) Pharmacokinetics intravenous ketoprofen. Therapeutic value in renal colic. Nephrologie, 10, 23-26.
10. Jamali, F. & Brocks, D.R. (1990) Clinical pharmacokinetics of ketoprofen and its enantiomers. Clinical Pharmacokinetics, 19, 197-217.
11. Jaussaud, P., Courtot, D. & Guyot, L. (1987) Identification of a flunixin metabolite in the horse by gas chromatography - mass spectrometry. Journal of Chromatography, 423, 123-130.
12. Kurosawa, M., Yamashita, S., Tsuji, T. & Ohtake, I. (1994) The metabolic fate of ketoprofen in the horse after oral and intramuscular administration. Proceedings of the 10th International Conference of Racing Analysts and Veterinarians, Stockholm, Sweden. pp. 17-22.
13. Landoni, M.F., Soraci, A.L., Delatour, P. & Lees, P. (1997) Enantioselective behavior of drugs used in domestic animals: a review. Journal of Veterinary Pharmacology Therapeutics, 20, 1-16.
14. Lewellen, O.R. & Templeton, R. (1976) The pharmacokinetics of ketoprofen in man during and after repeated oral dosing (50 mg q.i.d.) with Orudis. Scandinavian Journal of Rheumatology (Suppl. 197) 6, 53-62.
15. Li, K.L., Vogel, R., Jeffcoat, M.K., Alfano, M.C., Smith, M.A., Collins, J.G. & Offenbacher, S. (1996) The effect of ketoprofen cream on periodontal disease in rhesus monkeys. Journal of Periodontal Research, 31, 525-532.
16. Netter, P., Bannwarth, B., Lapicque, F., Harrewyn, J.M , Frydman, A., Tomisier, J.N., Gaucher, A. & Royer, R.J. (1987) Total and free ketoprofen in serum and synovial fluid after intramuscular injection. Clinical Pharmacology, 42, 555-561.
17. Oukessou, M., Bouljihad, F., Van, G.F. & Alvinerie, M. (1996) Pharmacokinetics of ketoprofen in the donkey (Equus asinus). Journal of Veterinary Medicine A, 43, 423-426.
18. Oukessou, M., Zin Filali, R., Van, G.F. & Alvinerie, M. (1995) Ketoprofen pharmacokinetics in the camel (Camelus dromedarius). Indian Veterinary Journal, 72, 233-236.
19. Owens, J.G., Kamerling, S.G. & Barker, S.A. (1995a) Pharmacokinetics of ketoprofen in healthy horses and horses with acute synovitis. Journal of Veterinary Pharmacology, 18, 187-195.
20. Owens, J.G., Kamerling, S.G., Stanton, S.R. & Keowen, M.L. (1995b) Effect of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse. Equine Veterinary Journal, 27, 296-300.
21. Owens, J.G., Kamerling, S.G., Stanton, S.R., Keowen, M. & Prescott-Mathews, J.S. (1996) Effect of pretreatment with ketoprofen and phenylbutazone on experimentally induced synovitis in horses. American Journal of Veterinary Research, 57, 866-874.
22. Populaire, P., Terlain, B., Pascal, S., Decouvelaere, B., Renard, A. & Thomas, J.P. (1973) Biological behavior: serum levels, excretion and biotransformation of (benzoyl-3 phenyl)-2 propionic acid or ketoprofen in animals and man. Annales Pharmaceutiques Francaises, 31, 735-749.
23. Rowland, M. & Tozer, T.N. (1989) Clinical Pharmacokinetics, 2nd edn. Lea and Febiger, Pennsylvania.
24. Rudy, A.C., Liu, Y., Brater, C. & Hall, S.D. (1998) Stereoselective pharmacokinetics and inversion of (R)-ketoprofen in healthy volunteers. Journal of Clinical Pharmacology, 38, 3S-10S.
25. Ryan, M., Todi, F. & Mendonca, M. (1994) The fate of ketoprofen in the horse after administration of ketofen. Proceedings of the 10th International Conference of Racing Analysts and Veterinarians, Stockholm, Sweden. pp. 28-32.
26. Sams, R., Gerken, D.F. & Ashcraft, S.M. (1995) Pharmacokinetics of ketoprofen after multiple intravenous doses to mares. Journal of Veterinary Pharmacology and Therapeutics, 18, 108-116.
27. Satterwhite, J.H. & Boudinot, F.D. (1992) Pharmacokinetics of ketoprofen in rats. Effect of Age and Dose. Biopharmaceutics and Drug Disposition, 13, 197-212.
28. Schmitt, M. & Guentert, T.W. (1990) Biopharmaceutical evaluation of ketoprofen following intravenous, oral, and rectal administration in dogs. Journal of Pharmaceutical Science, 79, 614-616.
29. Short, C.R., Guthrie, A.J., Swan, G.E., Motijie, S.G.M., Killeen, E.M., Nurton, J.P. & Stanley, S. (1996) The effect of ketoprofen on a soft tissue information model in thoroughbred horses. Proceedings of the 11th International Conference of Racing Analysts and Veterinarians, Queensland, Australia. pp. 111-116.
30. Skeith, K.J., Russell, A.S. & Jamali, F. (1993) Ketoprofen pharmacokinetics in the elderly: influence of rheumatic disease, renal function, and dose. Journal of Clinical Pharmacology, 33, 1052-1059.
31. Vane, J.R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biology), 231, 232-235.
32. Wasfi, I.A., Hadi, A.A.A., Alkatheeri, N.A., Barezaiq, I.M. El-Ghazali, M., Boni, N.S. & Zorob, O. (1998a) Identification of a flunixin metabolite in camel by gas chromatography - mass spectrometry. Journal of Chromatography B, 709, 209-215.
33. Wasfi, I.A., Boni, N.S., Hadi, A.A.A., El Ghazali, M., Zorob, O., Alkatheeri, N.A. & Barezaiq, I.M. (1998b) Pharmacokinetics, metabolism and urinary detection time of flunixin after intravenous administration in camels. Journal of Veterinary Pharmacology and Therapeutics, 21, 203-208.
34. Wasfi, I.A., Hadi, A.A.A., Zorob, O., AlGhazali, M.O. & Boni, N.S. (1997) Pharmacokinetics of phenylbutazone in camels. American Journal of Veterinary Research, 58, 636-640.
35. Wilson, T. (1984) The Camel. The print house Pte, Singapore.