Frequent loss of expression or aberrant alternative splicing of P2XM, a p53-inducible gene, in soft-tissue tumours

British Journal of Cancer

Volumn 80, Issue 8, 1999, Pages 1185-1189

  Nawa, G ^a   Miyoshi, Y ^a   Yoshikawa, H ^a,b   Ochi, T ^a   Nakamura, Y ^a,c  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Alternative splice; mdm2; P2XM; p53; Soft tissue sarcoma

Indexed keywords

PROTEIN P53; PURINE P2 RECEPTOR;

ADOLESCENT; ADULT; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; BENIGN TUMOR; CHILD; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE INDUCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SOFT TISSUE SARCOMA; SOFT TISSUE TUMOR;

AMINO ACID SEQUENCE; DNA MUTATIONAL ANALYSIS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; MALE; MOLECULAR SEQUENCE DATA; RECEPTORS, PURINERGIC P2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOMA; SOFT TISSUE NEOPLASMS; TRANSCRIPTION, GENETIC;

EID: 0032986634     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690484     Document Type: Article

References (30)

1. Andreassen A, Oyjord T, Hovig E, Holm R, Florenes VA, Nesland JM, Myklebost O and Hoie J (1993) p53 abnormalities in different sub-types of human sarcomas, Cancer Res 53: 468-471
2. Buckbinder L, Talbott R, Velasco MS, Takenaka I, Faha B, Seizinger BR and Kley N (1995) Induction of the growth inhibitor IGF binding protein 3 by p53. Nature 377: 646-649
3. Castresana JS, Barrios C, Gómez L and Kreicbergs A (1994) No association between c-myc amplification and tp53 mutation in sarcoma tumorigenesis. Cancer Genet Cytogenet 76: 47-49
4. Castresana JS, Rubio M-P, Gómez L, Kreicbergs A, Zetterberg A and Barrios C (1995) Detection of tp53 gene mutations in human sarcomas. Eur J Cancer 31A: 735-738
5. Cordon-Cardo C, Latres E, Drobnjak M, Oliva M, Pollack D, Woodruff JM, Marecbal V, Chen J, Brennan MF and Levine AJ (1994) Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 54: 794-799
6. El-Deiry WS, Tokino T, Velculesco VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW and Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825
7. Enjoji M and Hashimoto H (1984) Diagnosis of soft-tissue sarcomas. Pathol Res Pract 178: 215-226
8. Enzinger FM, Lattes R and Torloni R (1969) Histologic typing of soft-tissue tumors. International classification of tumors 3: WHO, Geneva
9. Felix CA, Kappel CC, Mitsudomi T, Nau MM, Tsokos M, Crouch GD, Nisen PD, Winick NJ and Helman IJ (1992) Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma. Cancer Res 52: 2243-2247
10. Furuhata T, Tokino T, Urano T and Nakamura Y (1996) Isolation of a novel GPI-anchored gene specifically regulated by p53: correlation between its expression and anticancer drug sensitivity. Oncogene 13: 1965-1970
11. Haupt Y, Maya R, Kazaz A and Oren M (1997) Mdm2 promotes the rapid degradation uf p53. Nature 387: 296-9
12. Kastan MB, Zhan Q, El-Deiry WS, Carrier E, Jacks T, Walsh WV, Plunkett BS, Vogelstein B and Fornace AJ (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangieclasia. Cell 71: 587-597
13. Kubbutat MH, Jones SN and Vousden KH (1997) Regulation of p53 stability by Mdm2. Nature 387: 299-303
14. Latres E, Drobnjak M, Pollack D, Oliva MR, Ramos M, Karpeh M, Woodruff JM and Cordon-Cardo C (1994) Chromosome-17 abnormalities and tp53 mutations in adult soft-tissue sarcoma. Am J Pathol 145: 345-355
15. Leach FS,Tokino T, Burrell M, Oliner JD, Smith S, Hill DE, Sidransky D, Kinzler KW and Vogelstein B (1993) p53 mutations and mdm2 amplification in human soft-tissue sarcomas. Cancer Res 53: 2231-2234
16. Masuda H, Miller C, Koeffler H, Battifora H and Cline M (1987) Rearrangement of the p53 gene in human osteogenic sarcomas. Proc Natl Acad Sci USA 84: 7716-7719
17. Miyashita T and Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human has gene. Cell 80: 293-299
18. Morris GE, Bischoff JR and Mathews MB (1996) Transcriptional activation of the human proliferating cell nuclear antigen promoter by p53. Proc Natl Acad Sci USA 93: 895-899
19. Okamoto K and Beach D (1994) Cyclin G is a transcriptional target of p53 tumor suppressor protein. EMBO J 13: 4816-4822
20. Oliner ID, Kinzler KW, Meltzler PS, George DL and Vogelstein B (1992) Amplificalion of a gene encoding a p53-associated protein in human sarcomas. Nature 358: 80-83
21. Owens GP, Hahn WE and Cohen JJ (1991) Identification of mRN As associated with programmed cell death in immature thymocytes. Mol Cel Biol 11: 4177-4188
22. Schneider-Stock R, Radig K, Oda Y, Mellin W, Rys J, Niczabitowski A and Roessner A (1997) p53 gene mutations in soft-tissue sarcomas - correlations with p53 immunohistochemistry and DNA ploidy. J Cancer Res Clin Oncol 123: 211-218
23. Stratton MR, Moss S, Warren W, Patterson H, Clark J, Fisher C, Fletcher C, Ball A, Thomas M, Gusterson B and Cooper C (1990) Mutation of the p53 gene in human soft-tissue sarcomas: association with abnormalities of the Rb1 gene. Oncogene 5: 1297-1301
24. Taubert H, Würl P, Meye A, Berger D, Thamm B, Neumann K, Hinze R, Schmidt H and Rath FW (1995) Molecular and immunohistochemical p53 status in liposarcoma and malignant fibrous histiocytoma. Cancer 76: 1187-1195
25. Taubert H, Meye A and Würl P (1996) Prognosis is correlated with p53 mutation type for soft tissue sarcoma patients. Cancer Res 56: 4134-4136
26. Toguchida J, Yamaguchi T, Ritchie B, Beauchamp RL, Dayton SH and Herrera GE (1992) Mutation spectrum of the p53 gene in bone and soft-tissue sarcomas. Cancer Res 52: 6194-6199
27. Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y and Tokino T (1997) Cloning of P2XM, a novel human P2X receptor gene regulated by p53. Cancer Res 57: 3281-3287
28. Vogelstein B and Kinzler KW (1992) p53 function and dysfunction. Cell 70: 523-526
29. Wu X, Bayle JH, Olson D and Levine AJ (1993) The p53-mdm-2 autoregulatory feedback loop. Genes Devel 7: 1126-1132
30. Würl P, Taubert H, Bache M, Kroll J, Meye A, Berger D, Siermann A, Holzhausen H J, Hinze R, Schmidt H and Rath F-W (1996) Frequent occurrence of p53 mutations in rhabdomyosarcoma and leiomyosarcoma, but not in fibrosarcoma and malignant neural tumors. Int J Cancer 69: 317-323