Glomerular size-selective dysfunction in NIDDM is not ameliorated by ACE inhibition or by calcium channel blockade

Kidney International

Volumn 55, Issue 3, 1999, Pages 984-994

  Ruggenenti, Piero ^b   Mosconi, Lidia ^b   Sangalli, Fabio ^b   Casiraghi, Federica ^b   Gambara, Vincenzo ^b   Remuzzi, Giuseppe ^b   Remuzzi, Andrea ^a  

^a MARIO NEGRI INST PHARMACOL RES   (Italy)

^b NONE

Author keywords

Angiotensin converting enzyme; Blood pressure; Dextran; Glomerular sieving; Non insulindependent diabetes mellitus; Proteinuria

Indexed keywords

ALBUMIN; CALCIUM CHANNEL BLOCKING AGENT; DEXTRAN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMMUNOGLOBULIN G; NITRENDIPINE; PERINDOPRIL;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOUBLE BLIND PROCEDURE; FEMALE; GLOMERULUS FILTRATION; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; KIDNEY BLOOD FLOW; MALE; MEMBRANE PERMEABILITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL;

EID: 0032986629     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.055003984.x     Document Type: Article

References (45)

1. Myers BD, Winetz JA, Chui F, Michaels AS: Mechanisms of proteinuria in diabetic nephropathy: A study of glomerular barrier function. Kidney Int 21:633-641, 1982
2. Deckert T, Feldt-Rasmussen B, Djurup R, Deckert M: Glomerular size and charge selectivity in insulin dependent diabetes mellitus. Kidney Int 33:100-106, 1988
3. Tomlanovich S, Deen WM, Jones WW III, Schwartz HC, Myers BD: Functional nature of glomerular injury in progressive diabetic glomerulopathy. Diabetes 36:556-565, 1987
4. Mosconi L, Remuzzi A, Ruggenenti P, Sangalli F, Vendramin G, Moriggi M, Remuzzi G: ACE inhibition reduces proteinuria and improves glomerular size-selectivity of nephrotic patients with idiopatic membranous nephropathy. (abstract) J Am Soc Nephrol 8:93, 1997
5. Nakamura Y, Myers BD: Charge selectivity of proteinuria in diabetic glomerulopathy. Diabetes 37:1202-1211, 1988
6. Benigni A, Zoja C, Remuzzi G: The renal toxicity of sustained glomerular protein traffic. Lab Invest 73:461-468, 1995
7. Benigni A, Remuzzi G: Glomerular protein trafficking and progression of renal disease to terminal uremia. Semin Nephrol 16:151-159, 1996
8. Morelli E, Loon N, Meyer TW, Peters W, Myers BD: Effects of converting-enzyme inhibition on barrier function in diabetic glomerulopathy. Diabetes 39:76-82, 1990
9. Remuzzi A, Ruggenenti P, Mosconi L, Pata V, Viberti G, Remuzzi G: Effect of low-dose enalapril on glomerular size-selectivity in human diabetic nephropathy. J Nephrol 6:36-43, 1993
10. Rossing P, Hommel E, Smidt UM, Parving HH: Reduction in albuminuria predicts diminished progression in diabetic nephropathy. Kidney Int 45(Suppl):S145-S149, 1994
11. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD: The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. N Engl J Med 329:1456-1462, 1993
12. Weidmann P, Schneider M, Bohlen L: Therapeutic efficacy of different antihypertensive drugs in human diabetic nephropathy: An updated meta-analysis. Nephrol Dial Transplant 10(Suppl):39-45, 1995
13. Myers BD, Nelson RG, Tan M, Beck GJ, Bennet PH, Knowler WC, Blouch K, Much WE: Progression of overt nephropathy in non-insulin-dependent diabetes. Kidney Int 47:1781-1789, 1995
14. Gambara V, Mecca G, Remuzzi G, Bertani T: Heterogeneous nature of renal lesions in type II diabetes. J Am Soc Nephrol 3:1458-1466, 1993
15. Remuzzi A, Viberti G, Ruggenenti P, Battaglia C, Pagni R, Remuzzi G: Glomerular response to hyperglycemia in human diabetic nephropathy. Am J Physiol 259:F545-F552, 1990
16. Dalton RN, Wiseman MJ, Turner C, Viberti GC: Measurement of urinary para-aminohippuric acid in glycosuric diabetics. Kidney Int 34:117-120, 1988
17. Remuzzi A, Perticucci E, Ruggenenti P, Mosconi L, Limonta M, Remuzzi G: Angiotensin converting enzyme inhibition improves glomerular size-selectivity in IgA nephropathy. Kidney Int 39:1267-1273, 1991
18. Battilana C, Zhang H, Olshen R, Wexler L, Myers BD: PAH extraction and the estimation of plasma flow in the diseased human kidney. Am J Physiol 261:F726-F733, 1991
19. Oliver JD, Anderson S, Troy JL, Brenner BM, Deen WM: Determination of glomerular size-selectivity in the normal rat with Ficoll. J Am Soc Nephrol 3:214-228, 1992
20. Scott TA, Melvin EH: Determination of dextran with anthrone. Anal Chem 25:1656-1661, 1953
21. Remuzzi A, Battaglia C, Rossi L, Zoja C, Remuzzi G: Glomerular size selectivity in nephrotic rats exposed to diets with different protein content. Am J Physiol 253:F318-F327, 1987
22. Deen WM, Bridges CR, Brenner BM, Myers BD: Heteroporous model of glomerular size selectivity: Application to normal and nephrotic humans. Am J Physiol 249:F374-F389, 1985
23. Deen WM, Robertson CR, Brenner BM: A model of glomerular ultrafiltration in the rat. Am J Physiol 223:1178-1183, 1972
24. Grieve AP: Crossover versus parallel designs, in Statistical Methodologv in the Pharmaceutical Sciences, edited by Berry DA, New York, M. Dekker, 1990
25. Zatz R, Dunn BR, Meyer TW, Anderson S, Rennke HG, Brenner BM: Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension. J Clin Invest 77:1925-1930, 1986
26. Anderson S, Rennke HG, Garcia DL, Brenner BM: Short and long term effects of antihypertensive therapy in the diabetic rat. Kidney Int 36:526-536, 1989
27. Remuzzi A, Puntorieri S, Battaglia C, Bertani T, Remuzzi G: Angiotensin converting enzyme inhibition ameliorates glomerular filtration of macromolecules and water and lessens glomerular injury in the rat. J Clin Invest 85:541-549, 1990
28. Friedman S, Strobel S, Field EH, Silverman E, Myers BD: Glomerular capillary wall function in human lupus nephritis. Am J Physiol 246:F580-F591, 1984
29. Zietse R, Derk FH, Welmar W, Schalekamp MA: Effect of atrial natriuretic paptide on renal and vascular permeability in diabetes mellitus. J Am Soc Nephrol 5:2057-2066, 1995
30. Winetz JA, Golbetz H, Spencer RJ, Lee JA, Myers BD: Glomerular function in advanced human diabetic nephropathy. Kidney Int 21:750-756, 1982
31. Blouch K, Deen WM, Fauvel JP, Bialek J, Derby G, Myers BD: Molecular configuration and glomerular size-selectivity in healthy and nephrotic humans, (abstract) J Am Soc Nephrol 7:1329, 1996
32. Shemesh O, Ross JC, Deen WM, Grant GW, Myers BD: Nature of the glomerular capillary injury in human membranous glomerulopathy. J Clin Invest 77:868-877, 1986
33. Guasch A, Hashimoto H, Sibley RK, Deen WM, Myers BD: Glomerular dysfunction in nephrotic humans with minimal changes or focal glomerulosclerosis. Am J Physiol 260:F728-F737, 1991
34. Myers BD, Guasch A: Selectivity of the glomerular nitration barrier in healthy and nephrotic humans. Am J Nephrol 13:311-317, 1993
35. Ting RH, Kristal B, Myers BD: The biophysical basis of hypofiltration in nephrotic humans with membranous nephropathy. Kidney Int 45:390-397, 1994
36. Bakris GL, Copley JB, Vichnair N: Blood pressure reduction and progression of diabetic nephropathy in African Americans, (abstract) J Am Soc Nephrol 6:446, 1995
37. Davidson MG, Deen WM: Hindered diffusion of water-soluble macromolecules in membranes. Macromolecules 21:3474-3481,1988
38. Ruggenenti P, Remuzzi G: The diagnosis of renal involvement in non-insulin-dependent diabetes mellitus. Curr Opin Nephrol Hypertens 6:141-145, 1997
39. Ruggenenti P, Remuzzi G: The renoprotective action of angiotensin-converting enzyme inhibitors in diabetes. Exp Nephrol 4(Suppl 1):53-60, 1996
40. Nielsen FS, Rossing P, Gall M-A, Skøtt P, Smidt UM, Parving H-H: Long-term effect of lisinopril and atenolol on kidney function in hypertensive NIDDM subjects with diabetic nephropathy. Diabetes 46:1182-1188, 1997
41. Parving H-H, Rossing P: The use of antihypertensive agents in prevention and treatment of diabetic nephropathy. Curr Opin Nephrol Hypertens 3:292-300, 1994
42. Walker WG, Hermann J, Anderson J, Zachary J, Russell RP: Blood pressure (BP) control slows decline of glomerular filtration rate (GFR) in hypertensive NIDDM patients, (abstract) J Am Soc Nephrol 3:339, 1992
43. Lebovitz HE, Wiegmann TB, Cnaan A, Shahinfar S, Sica DA, Broadstone V, Schwartz SL, Mengel MC, Segal R, Versaggi JA, Bolton WK: Renal protective effects of enalapril in hypertensive NIDDM: Role of baseline albuminuria. Kidney Int 45(Suppl 45):S150-S155, 1994
44. Mosconi L, Ruggenenti P, Perna A, Mecca G, Remuzzi G: Nitrendipine and enalapril improve albuminuria and glomerular filtration rate in non-insulin dependent diabetes. Kidney Int 49(Suppl 55):S91-S93, 1996
45. Ravid M, Savin H, Jutrin I, Bental T, Lang R, Lishner M: Long-term effect of ACE inhibition on development of nephropathy in diabetes mellitus type II. Kidney Int 45(Suppl 45): S161-S164, 1994