Improvement of flutamide-induced hepatotoxicity by ursodeoxycholic acid in male rats

Kanzo/Acta Hepatologica Japonica

Volumn 40, Issue 4, 1999, Pages 227-234

  Ichimura, Eiji ^a   Hara, Kazuhisa ^a   Matsuzaki, Yasushi ^b   Mikio, D O I ^c  

^a NIPPON KAYAKU CO LTD   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c Tsukuba Medical Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FLUTAMIDE; LACTATE DEHYDROGENASE; PHENOBARBITAL; URSODEOXYCHOLIC ACID;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE CALCULATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER HISTOLOGY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; RAT;

EID: 0032986464     PISSN: 04514203     EISSN: None     Source Type: Journal    
DOI: 10.2957/kanzo.40.227     Document Type: Article

References (28)

1. Caubet JF, Tosteson TD, Dong EW, et al: Maximum androgen blockade in advanced prostate cancer. Urology 49 : 71-78, 1997
2. Rosman AS, Frissora -Rodeo C, Marshall AT, et al: Cholestatic hepatitis following flutamide. Dig Dis Sci 38 : 1756-1759, 1993
3. Wysowski DK, Fourcroy JL: Flutamide hepatotoxicity. J Urol 155 : 209-212, 1996
4. Moller S, Iversen P, Franzmann M: Flutamide-induced liver failure. J Hepatol 10 : 346-349, 1990
5. McDonnell ND, Livingston RB: Severe reversible neutropenia following treatment of prostate cancer with flutamide. J Urol 151 : 1353-1354, 1994
6. Fau D, Eugene D, Berson A, et al: Toxicity of the antiandrogen flutamide in isolated rat hepatocytes. J Pharamacol Exp Ther 269: 954-962, 1994
7. Matsuzaki Y, Tanaka N, Osuga T, et al: Improvement of biliary enzyme levels and itching as a result of long-term administration of ursodeoxycholic acid in primary biliary cirrhosis. Am J Gastroenterol 85 : 15-23, 1990
8. Matsuzaki Y, Doi M, Tanaka N, et al: Biochemical and histological changes after more than four years of treatment of ursodeoxycholic acid in primary biliary cirrhosis. J Clin Gastroenterol 18 : 36-41, 1994
9. Cicognani C, Malavolti M, Morselli-Labate AM, et al: Flutamide-induced toxic hepatitis. Dig Dis Sci 41 : 2219-2221, 1996
10. Mclain GE, Sipes IG, Brown BR : An animal model of halothane hepatotoxicity ; roles of enzyme induction and hypoxia. Anesthesiology 51 : 321-326, 1979
11. Shet MS, McPhaul M, Fisher CW, et al: Metabolism of the antiandrogenic drug (flutamide) by human CYP1A2. Drug Metab and Disposit 25 : 1298-1303, 1997
12. Blouin RA, Dickson P, Mcnamara PJ, et al: Phenobarbital induction and Acetaminophen Hepatotoxity. J Pharmacol Exp Ther 243 : 565-570, 1987
13. Vorne M, Arvela P and Alavaikko M: Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment. Path Res Pract 172 : 372-383, 1981
14. Galle PR, Theilmann L, Raedsch R, et al: Ursodeoxycholate reduces hepatotoxity of bile salts in primary human hepatocytes. Hepatology 12 : 486-491, 1990
15. Güldütuna S, Zimmer G, Imhof M, et al : Molecular aspects of membrane stabilization by ursodeoxycholate. Gastroenterology 104 : 1736-1744, 1993
16. Tanaka H, Makino Y, Miura T, et al: Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. J Immunol 156 : 1601-1608, 1996
17. Nava-Ocampo AA, Suster S, Muriel P: Effect of colchiceine and ursodeoxycholic acid on hepatocyte and erythrocyte membranes and liver histology in experimentally induced carbon tetrachloride cirrhosis in rats. Eur J Clin Invest 27 : 77-84, 1997
18. Kulcsár-Gergely J, Kulcsár A : Studies on the effect of ursodeoxycholic acid on rats with acute carbontetrachloride injury. Arzneim-Forsch/Drug Res 47 : 659-661, 1997
19. Rudi J, Schlenker T, Raedsch R, et al: Effect of ursodeoxycholic acid on biochemical parameters , hepatocyte proliferation and liver histology in galactosamine hepatitis in the rat. Res Exp Med 195 : 309-315, 1995