A new concept regarding the mechanism of action of omeprazole

International Journal of Clinical Pharmacology and Therapeutics

Volumn 37, Issue 6, 1999, Pages 286-293

  Puscas, I ^a,b   Coltau, M ^a   Baican, M ^c   Domuta, G ^a  

^a ACADEMY OF ROMANIAN SCIENTISTS   (Romania)

^b Ctr for Res and Medical Assistance   (Romania)

^c NONE

Author keywords

Carbonic anhydrase; Gastric acid secretion (GAS); H+K+ATPase; Omeprazole

Indexed keywords

CARBONATE DEHYDRATASE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; OMEPRAZOLE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; ERYTHROCYTE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY CELL; LUNG ALVEOLUS CELL; MALE; NONHUMAN; NORMAL HUMAN; PH; RANDOMIZED CONTROLLED TRIAL; STOMACH MUCOSA;

ADULT; ANIMALS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; GASTRIC MUCOSA; HUMANS; HYDROGEN-ION CONCENTRATION; ISOENZYMES; MALE; OMEPRAZOLE; RABBITS; SWINE;

EID: 0032985291     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. +-adenosinetriphosphatase. Biochemistry 32: 2345-2355
2. Davenport HW 1939 Gastric carbonic anhydrase. J Physiol (London) 97: 3243
3. Hersey SJ, Sachs G 1995 Gastric acid secretion. Physiol Rev 75: 155-189
4. Janowitz HD, Colcher H, Hollander F 1952 Inhibition of gastric secretion in dogs by carbonic anhydrase inhibitor 2-acetyl-amino-1,3,4-thiadiazole-5-sulfonamide. Am J Physiol 171: 325-330
5. +)-ATP-ase inhibitor depends upon the means of its activation. Biochem Pharmacol 36: 339-344
6. Khalifah RG 1971 The carbon dioxide hydration activity of carbonic anhydrase: stop-flow kinetic studies on the native human isozymes B and C. J Biol Chem 246: 2561-2573
7. Konturek SJ, Brzozowski T, Piastucki I, Radecki T 1983 Gastric cytoprotection by acetazolamide: role of endogenous prostaglandins. Digestion 28: 125-131
8. Lewin MJM 1982 Cell separation. In: Pretlow TG II, Pretlow TP (eds) Methods and Selected Application. Academic Press, New York, pp 223-245
9. Lindberg P, Nordberg P, Alimnger T 1986 The mechanism of action of the gastric acid secretion inhibitor omeprazole. J Med Chem 29: 1327-1329
10. Lindberg P, Branstrom A, Wallmark B 1990 Omeprazole: the first proton pump inhibitor. Med Res Rev 10: 1-54
11. +)-ATPase by omeprazole in isolated gastric vesicles requires proton transport. Biochim Biophys Acta 897: 41-51
12. Maren TH 1967 Carbonic anhydrase: chemistry, physiology and inhibition. Physiol Rev 47: 595-781
13. Maren TH, Wynns GC, Wistrand PJ 1993 Chemical properies of carbonic anhydrase IV, the membrane-bound enzyme. Mol Pharmacol 44: 901-905
14. Puscas I 1976 Les inhibiteurs de l'anhydrase carbonique dans le traitement de l'ulcere gastrique et duodenal. Archive Françaises des Maladies de l'Appareil Digestif 65: 577-583
15. Puscas I, Buzas G, Puscas C, Persa F 1989 Carbonic anhydrase inhibitors. Antisecretory and cytoprotective properties. Acta Physiol Hung 73: 167-177
16. Puscas I 1994 Carbonic Anhydrase and Modulation of Physiologic and Pathologic Processes in the Organism. Helicon Publ House, Timisoara, Romania
17. Puscas I, Coltau, M 1995a Inhibition of carbonic anhydrase by nitric oxide. Arzneimittel Forschung/Drug Res 8: 846-848
18. Puscas I, Coltau M 1995b Prostaglandins having vasodilating effects inhibit carbonic anhydrase while leukotriens B4 and C4 increase carbonic anhydrase activity. Int J Clin Pharmacol Ther 32: 176-181
19. Puscas I, Coltau M, Pasca R 1996 Non-steroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action. J Pharmacol Exp Ther USA 277: 1146-1148
20. Puscas I, Vlaicu R, Lazar A 1997 Isosorbide nitrates, nitroglycerine and sodium nitroprusside induce vasodilation, concomitantly inhibiting down to abolishment carbonic anhydrase I in erythrocytes. Am J Hypertens 10: 124-128
21. Robert A, Nezamis J, Lancaster C 1982 Antiulcer and cytoprotective effects of acetazolamide. Gastroenterology 82: 1163-1167
22. Sachs G, Carlsson E, Lindberg P, Wallmark B 1988 Gastric HK-ATP-ase as therapeutic target. Ann Rev Pharmacol Toxicol 28: 269-284
23. Soll AH 1998 Peptic ulcer and its complications In: Feldman M, Scharschmidt BF, Sleisenger MH (eds) Gastrointestinal and Liver Disease. Pathophysiology, Diagnosis, Management. Saunders, BT, Philadelphia, pp 620-678
24. Vorstrup S, Henriksen L, Paulson OB 1984 Effect of acetazolamide on cerebral blood flow and cerebral metabolic rate for oxygen. J Clin Invest 74: 1634-1639
25. Wallmark B, Jaresten BM, Larsson H 1983 Differentiation among inhibitory actions of omeprazole, cimetidine and SCN - on gastric acid secretion. Am J Physiol 245: G64-71
26. Wang Q 1993 Indomethacin abolishes cerebral blood flow increase in response to acetazolamide - induce extracellular acidosis: a mechanism for effect on hypercapnia? Cereb Blood Flow Metab 13: 724-727
27. Wistrand PJ 1984 Properties of membrane-bound carbonic anhydrase. Ann NY Acad Sci 429: 195-206