Signaling pathways in thrombin-induced actin reorganization in pulmonary artery endothelial cells

Experimental Lung Research

Volumn 25, Issue 1, 1999, Pages 23-39

  Zhao, Ying ^a   Davis, Harold W ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Actin; Endothelial cell; Myosin; Myosin light chain kinase; Protein kinase C

Indexed keywords

ACTIN; CALCIMYCIN; CALCIUM ION; CALMODULIN; MYOSIN LIGHT CHAIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; THAPSIGARGIN; THROMBIN;

ACTIN POLYMERIZATION; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CYTOSKELETON; ENDOTHELIUM CELL; ENZYME ACTIVATION; LUNG ENDOTHELIUM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; CATTLE; CELLS, CULTURED; CYTOSKELETON; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN KINASE; PHOSPHORYLATION; PROTEIN KINASE C; PULMONARY ARTERY; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; THROMBIN;

EID: 0032984388     PISSN: 01902148     EISSN: None     Source Type: Journal    
DOI: 10.1080/019021499270402     Document Type: Article

References (30)

1. Garcia JGN, Sifinger-Birnboim A., Bizios R, Del Vecchio PJ, Fenton JW, Malik AB: Thrombin-induced increase in albumin permeability across the endothelium. J Cell Physiol. 1986;128:96-104.
2. Schaeffer RC, Gong F, Bitrick MS, Smith TL: Thrombin and bradykinin initiate discrete endothelial solute permeability mechanisms. Am J Physiol. 1993;264:H1798-H1809.
3. Majno G, Palade GE: Studies on inflammation: the effect of histamine and serotonin on vascular permeability; an electron microscopic study. J Biophys Biochem Cytol. 1961;11:571-585.
4. Shasby DM, Shasby SS, Sullivan JM, Peach MJ: Role of endothelial cell cytoskeleton in control of endothelial permeability. Circ Res. 1982;51:657-661.
5. Moy AB, Shasby SS, Scott BD, Shasby DM: The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells. J Clin Invest. 1993;92:1198-1206.
6. Schnittler H-J, Wilke A, Gress T, Suttorp N, Drenckhahn D: Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium. J Physiol. 1990;431:379-401.
7. Garcia JGN, Davis HW, Patterson CE: Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation. J Cell Physiol. 1995;163:510-522.
8. Wysolmerski RB, Lagunoff D: Involvement of myosin light-chain kinase in endothelial cell retraction. Proc Natl Acad Sci USA. 1990;87:16-20.
9. DeLanerolle P, Paul RJ: Myosin phosphorylation/dephospborylation and regulation of airway smooth muscle contractility. Am J Physiol. 1991;261:L1-L14.
10. Lynch JJ, Ferro TJ, Blumenstock FA, Brockenauer AM, Malik AB: Increased endothelial albumin permeability mediated by protein kinase C activation. J Clin Invest. 1990;85:1991-1998.
11. Oliver JA: Adenylate cyclase and protein kinase C mediate opposite actions on endothelial junctions. J Cell Physiol. 1990;145:536-542.
12. Patterson CE, Davis HW, Schaphorst KL, Garcia JGN: Mechanisms of cholera toxin prevention of thrombin- and PMA-induced endothelial cell barrier dysfunction. Microvas Res. 1994;48:212-235.
13. Goligorsky MS, Menton DN, Laszlo A, Lum H: Nature of thrombin-induced sustained increase in cytosolic calcium concentration in cultured endothelial cells. J Biol Chem. 1989;264:16771-16775.
14. Sakamoto T, Hinton DR, Sakamoto H, Gopalakrishna R, Ryan DJ, McDonnell PJ: Thrombin induced cytoskeletal change in cultured bovine corneal endothelial cells mediated via protein kinase C pathway. Current Eye Res. 1995;14:35-45.
15. Goeckeler ZM, Wysolmerski RB: Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization and myosin phosphorylation. J Cell Biol. 1995;130:613-627.
16. Bray D, Thomas C: Unpolymerized actin in fibroblasts and brain. J Mol Biol. 1976;105:527-544.
17. Kitazumi K, Tasaka K: Thrombin-stimulated phosphorylation of myosin light chain and its possible involvement in endothelin-I secretion from porcine aortic endothelial cells. Biochem Pharmacol. 1992;43:1701-1709.
18. Laposata M, Dovnarsky DK, Shin HS: Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro. Blood. 1983;62:549-556.
19. 77 and vimentin and enhances albumin permeability across cultured bovine artery endothelial cell monolayers. J Cell. Physiol. 1992;153:62-75.
20. Jennings LK, Fox JEB, Edwards HH, Phillips DR: Changes in the cytoskeletal structure of human platelets following thrombin activation. J Biol Chem. 1989;256:6927-6932.
21. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
22. Persechini A, Kamm KE, Stull JT: Different phosphorylated forms of myosin in contracting tracheal smooth muscle. J Biol Chem. 1986;261:6293-6299.
23. Zhao Y, Davis HW: Thrombin-induced phosphorylation of the myristoylated alanine-rich C kinase substrate (MARCKS) protein in bovine pulmonary artery endothelial cells. J Cell Physiol. 1996;169:350-357.
24. Thastrup O, Dawson AP, Scharff O, Foder B, Cullen PJ, Drobak BK, Bjerrum PJ, Christensen SB, Hanley MR: Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents Actions. 1989;27:17-23.
25. 2+ influx in endothelial cells. FASEB J. 1998;12:341-348.
26. Wong MKK, Gotlieb AI: Endothelial monolayer integrity. Perturbation of F-actin filaments and the dense peripheral band-vinculin network. Arteriosclerosis. 1990;10:76-84.
27. Nakanishi S, Yamada K, Iwahashi K, Kuroda K, Kase H. KT5926, a potent and selective inhibitor of myosin light chain kinase. Mol Pharmacol. 1990;37:482-488.
28. Lum H, Malik AB: Mechanisms of increased endothelial permeability. Can J Physiol Pharmacol. 1996;74:787-800.
29. Gescher A: Towards selective pharmacological modulation of protein kinase C: opportunities for the development of novel antineoplastic agents. BrJ Cancer. 1992;66:10-19.
30. Scholey JM, Taylor KA, Kendrick-Jones J: Regulation of non-muscle myosin assembly by calmodulin-dependent light chain kinase. Nature. 1980;287:233-235.