90-Day oral toxicity study of D-tagatose in rats

Regulatory Toxicology and Pharmacology

Volumn 29, Issue 2 I, 1999, Pages

  Kruger, Claire L ^a   Whittaker, Margaret H ^a   Frankos, Vasilios H ^a   Trimmer, Gary W ^b  

^a ENVIRON INTERNATIONAL CORPORATION   (United States)

^b EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN; TAGATOSE;

ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG SAFETY; FEMALE; FOOD INTAKE; LIVER CELL; LIVER WEIGHT; MALE; NONHUMAN; OSMOSIS; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

EID: 0032984176     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1998.1262     Document Type: Article

References (14)

1. Borzelleca, J. F. (1996). A proposed model for safety assessment of macronutrient substitutes. Regul. Toxicol. Pharmacol. 23, S15-S18.
2. Dunnett, C. W. (1964). New tables for multiple comparisons with a control, Dunnett's test. Biometrics 20, 482-491.
3. Emmerson, J. L. (1993).On the Significance of Weight Loss (Decrement) in Safety Studies. The Toxicology Forum 1993 Annual Summer Meeting. Aspen, CO.
4. U.S. Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition. (1993). Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food. "Redbook II. " Draft report.
5. Holland, M., and Wolf, D. A. (1973). Non-parametric Statistical Methods, Wiley, New York.
6. Laerke, H. N., and Jensen, B. B. (1998). In vitro fermentation pattern of D-tagatose with an adapted and unadapted microflora from the gastrointestinal tract of pigs. Submitted for publication.
7. Livesey, G., and Brown, J. (1990). A Study Designed to Determine the Calorific Values of Sugar Substitutes Using a New Model of Energy Expenditure in the Rat. Internal confidential report. AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich, NR4 7UA, England.
8. Miller, F. N. (1978). Perry and Miller's Pathology. 3rd ed. Little, Brown, Boston.
9. Munro, I. C., McGirr, L. G., Nestmann, E. R., and Kille, J. W. (1996). Alternative approaches to the safety assessment of macronutrient substitutes. Regul. Toxicol. Pharmacol. 23, S6-S14.
10. Newberne, P. M. (1997). 90-Day Dietary Oral Toxicity Study in Rats with D-Tagatose: Histomorphologic Observations in the Liver of Rats Fed a Control Diet or the High Dose of D-Tagatose. Unpublished review.
11. Saunders, J. P. (1989). Feeding and Metabolism Study of D-Tagatose in Adapted Rats. Biospherics Incorporated. Company confidential report.
12. Saunders, J. P. (1992). Multiple Fat Rat Study. Biospherics Incorporated, Company confidential report.
13. 14C] tagatose in the rat. In press.
14. Snedecor, G. W., and Cochran, W. G. (1989). Statistical Methods, 8th ed. Iowa State Univ. Press, IA.