Radiosensitization of hypoxic tumour cells by S-nitroso-N-acetylpenicillamine implicates a bioreductive mechanism of nitric oxide generation

British Journal of Cancer

Volumn 79, Issue 7-8, 1999, Pages 1085-1089

  Janssens, M Y ^a,b   Verovski, V N ^a   Van Den Berge, D L ^a   Monsaert, C ^a   Storme, G A ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

Hypoxia; Nitric oxide; Radiosensitization; S nitroso N acetylpenicillamine

Indexed keywords

N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; RADIOSENSITIZING AGENT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIZATION; SENSOR; TUMOR CELL;

ANIMALS; CELL COUNT; CELL HYPOXIA; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; HALF-LIFE; MICE; NITRIC OXIDE; PENICILLAMINE; RADIATION-SENSITIZING AGENTS; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0032983223     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690173     Document Type: Article

References (14)

1. Adams GE (1992) Redox, radiation, and reductive bioactivation. Radiat Res 132: 129-139
2. Bates JN, Baker MT, Guerra R and Harrison DG ( 1991) Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required. Biochem Pharmacol 42: S157-S165
3. Clancy RM, Levartovsky D, Leszczynska-Piziak J, Yegudin J and Abramson SB (1994) Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary. Proc Natl Acad Sci USA 91: 3680-3684
4. Griffin RJ, Makepeace CM, Hur WJ and Song CW (1996) Radiosensitization of hypoxic tumor cells in vitro by nitric oxide. Int J Rad Onc Biol Phys 36: 377-383
5. Howard-Flanders P (1957) Effect of nitric oxide on the radiosensitivity of bacteria. Nature 180: 1191-1192
6. Ignarro LJ, Lippton H, Edwards JC, Baricos WH, Hyman AL, Kadowitz PJ and Gruetter CA (1981) Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharm Exp Ther 218: 739-749
7. Ioannidis I, Batz M, Paul T, Korth H, Sustmann R and Groot H (1996) Enhanced release of nitric oxide causes increased cytotoxicity of S-nitroso-n-acetyl-DL-penicillamine and sodium nitroprusside under hypoxic conditions. Biochem J 318: 789-795
8. Kowaluk EA and Fung HL (1990) Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols. J Pharm Exp Ther 255: 1256-1264
9. Maragos CM, Morley D, Wink D, Dunams TM, Saavedra JE, Hoffman A, Bove AA, Isaac L, Hrabie JA and Keefer LK (1991) Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 34: 3242-3247
10. Mitchell JB, Wink DA, DeGraff W, Gamson J, Keefer LK and Krishna MC (1993) Hypoxic mammalian cell radiosensitization by nitric oxide. Cancer Res 53: 5845-5848
11. Mitchell JB, Cook JA, Krishna MC, DeGraff W, Gamson J, Fisher J, Christodoulou D and Wink DA (1996) Radiation sensitisation by nitric oxide releasing agents. Br J Cancer 74: suppl. XXVII, S181-S184
12. Rochelle LG, Kruszyna H, Kruszyna R, Barchowsky A, Wilcox DE and Smith RP (1994) Bioactivation of nitroprusside by porcine endothelial cells. Toxicol Appl Pharmacol 128: 123-128
13. Stamler JS, Singel DJ and Loscalzo J (1992) Biochemistry of nitric oxide and its redox-activated forms. Science 258: 1898-1902
14. Verovski VN, Van den Berge DL, Soete GA, Bols BL and Storme GA (1996) Intrinsic radiosensitivity of human pancreatic tumour cells and the radiosensitising potency of the nitric oxide donor sodium nitroprusside. Br J Cancer 74: 1734-1742