A novel cleavage protocol for use with Rf-encoded split pool synthesis technology: Product cleavage and collection in standard 96 well format

Combinatorial Chemistry and High Throughput Screening

Volumn 2, Issue 1, 1999, Pages 29-32

  Andres, C J ^a   Swann, R T ^a   Grant Young, K ^a   D'Andrea, Stanley V ^a   Deshpande, Milind S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOTECHNOLOGY; DEGRADATION; FILTRATION; PRIORITY JOURNAL; TECHNIQUE;

EQUIPMENT AND SUPPLIES; HYDROLYSIS; PEPTIDE LIBRARY;

EID: 0032983123     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Nicolaou, K.C.; Xiao-Yi, X.; Parandoosh, A.; Senyei, A.; Nova, M. P. Angew. Chem. Int. Ed. Engl. 1995, 34, 2289-2290.
2. Xiao-Yi, X.; Zhao, C.; Potash, H.; Nova, M. P. J. Org. Chem. 1997, 62, 6029-6033.
3. Andres, C.J.; Swann, R.T.; Severino, J., Grant-Young, K.; Edinger, K.; Mongillo, J.; Deshpande, M. S. Biotechnol. Bioeng. (Comb Chem) 1998, 61, 93-94.
4. Material: Sears Craftsman #2 Phillips Screwdriver, Matrix 1.4 mL microtube, Matrix 96 position deep well block.
5. Although we archived Microkans in groups of 80, in an alternative scenario Microkans could be archived in groups of 96 allowing for each well of the deep well block to be used for cleavage and raising the number of cleaved compounds to 786 compounds (96 compounds per deep well block x 8 blocks).