Ocular effects of antimuscarinic compounds: Is clinical effect determined by binding affinity for muscarinic receptors or melanin pigment

Journal of Ocular Pharmacology and Therapeutics

Volumn 15, Issue 3, 1999, Pages 257-269

  German, E J ^a   Wood, D ^a   Hurst, M A ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CILIARY MUSCLE; DRUG EFFECT; LIGAND BINDING; NONHUMAN; RECEPTOR AFFINITY; RECEPTOR BINDING; SHEEP; SPECTROPHOTOMETRY; TARGET CELL;

EID: 0032982749     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.1999.15.257     Document Type: Article

References (26)

1. Gabelt, B.T. and Kaufman, P.L. Inhibition of aceclidine-stimulated outflow facility, accommodation and miosis in rhesus monkeys by muscarinic receptor subtype antagonists. Exp. Eye Res. 58:623-630, 1994.
2. 3-muscarinic receptor subtype predominates in the bovine iris sphincter smooth-muscle and ciliary processes. Invest. Ophthalmol. Vis. Sci. 31:590-593, 1990.
3. Poyer, J.F. and Kaufman, P.L. Effect of muscarinic agonists and receptor subtype-specific antagonists on the contractile responses of the isolated rhesus monkey ciliary muscle. Invest. Ophthalmol. Vis. Sci. 34:S921, 1993.
4. Woldemussie, E., Feldmann, B.J. and Chen, J. Characterization of muscarinic receptors in cultured human iris sphincter and ciliary smooth muscle cells. Exp. Eye Res. 56:385-392, 1993.
5. Ito, S. Re-examination of the structure of eumelanin. Biochim. Biophys. Acta 883:155-161, 1986.
6. Menon, I.A., Persad, S., Haberman, H.F. and Kurian, C.J. A comparative study of the physical and chemical properties of melanins isolated from human black and red hair. J. Invest. Dermatol. 80:202-206, 1983.
7. O'Connor-Davies, P.H., Hopkins, G.A. and Pearson, R.M.. The action and uses of ophthalmic drugs. 3rd ed., Butterworth & Co. Ltd., London, 1989.
8. Dillon, J.R., Tyhurst, C.W. and Yolton, R.L. The mydriatic effect of tropicamide on light and dark irides. J. Am. Optom. Assoc. 48:653-658, 1977.
9. Barbee, R.F. and Smith, W.O. A comparative study of mydriatic and cycloplegic agents in human subjects without eye disease. Am. J. Ophthalmol 44:617-622, 1957.
10. Taylor, S.A. Quantitative studies on acetylcholine receptors of the isolated iris sphincter muscle. Proc. Physiol. Soc. 239:6P-7P, 1974.
11. 3H-QNB to muscarinic receptors in sheep ciliary muscle and iris sphincter. Br. J. Pharmacol. 122:340P, 1997.
12. Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254, 1976.
13. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:3099-3108, 1973.
14. Lothian, G.F. Absorption spectrophotometry, 2nd ed., Hilger & Watts Ltd., London, 1958.
15. Scatchard, G. The attractions of small proteins for small molecules and ions. Ann. New York Acad. Sci. 51:660-672, 1949.
16. Salazar, M., Shimada, K. and Patil, P.N. Iris pigmentation and atropine mydriasis. J. Pharm. Exp. Ther. 197:79-88, 1976.
17. Manny, R.E., Zervas, H.J., Fern, K.D., White, J.M., Pass, A.F. and Martinez, A.T. Accommodative response following 1-percent cyclopentolate hydrochloride as a function of dosage and iris colour. Invest. Ophthalmol. Vis. Sci. 32:S1124, 1991.
18. Levine, L. Tropicamide-induced mydriasis in densely pigmented eyes. Am. J. Optom. Phys. Opt. 60: 673-677, 1983.
19. Larsson, B.S. Interaction between chemicals and melanin. Pigment Cell Res. 6:127-133, 1993.
20. German, E.J., Wood, D. and Hurst, M.A. Assessment of muscarinic receptor subtypes in the sheep iris sphincter and ciliary muscle by radioligand binding techniques. Br. J. Pharmacol. 122:341P, 1997.
21. Eglen, R.M. and Watson, N. Selective muscarinic receptor agonists and antagonists. Pharmacol. Toxicol. 78:59-68, 1996.
22. Eglen, R.M. and Whiting, R.L. Heterogeneity of vascular muscarinic receptors. J. Auton. Pharmacol. 19:233-245, 1990.
23. McIntyre, P. and Quinn, P. Characterisation and comparison of muscarinic receptors in the dog ciliary muscle with ileum. Br. J. Pharmacol. 115:139P, 1995.
24. 3 receptor antagonists. Life Sci. 56:861-868, 1995.
25. 3 antagonist. Pharmacol. Res. 31S:54, 1995.
26. German, E.J. Factors influencing the clinical effects of ocular antimuscarinic agents. University of Bradford PhD Thesis, UK, 1998.