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Biedenbach DJ, Barrett MS, Croco MAT, et al. BAY 12-8039, a novel fluoroquinolone: activity against important respiratory tract pathogens. Diagn Microbiol Infect Dis 1998 Sep; 32: 45-50
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Weiss K, Laverdiere M, Restieri C. Comparative activity of trovafloxacin and Bay 12-8039 against 452 clinical isolates of Streptococcus pneumoniae. J Antimicrob Chemother 1998 Oct; 42: 523-5
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Ji, B.1
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12
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0031026940
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Aldridge KE, Ashcraft DS. Comparison of the in vitro activities of Bay 12-8039, a new quinolone, and other antimicrobials against clinically important anaerobes. Antimicrob Agents Chemother 1997 Mar; 41: 709- 11
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Edlund C, Sabouri S, Nord CE. Comparative in vitro activity of BAY 12-8039 and five other antimicrobial agents against anaerobic bacteria. Eur J Clin Microbiol Infect Dis 1998 Mar; 17: 193-5
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Edlund, C.1
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Woodcock, J.M.1
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15
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Boswell FJ, Andrews JM, Wise R. Pharmacodynamic properties of BAY 12-8039 on Gram-positive and Gram-negative organisms as demonstrated by studies of time-kill kinetics and post-antibiotic effect. Antimicrob Agents Chemother 1997 Jun; 41: 1377-9
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16
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AI-Nawas B, Shah PM. Intracellular activity of ciprofloxacin and moxifloxacin, a new 8-methoxyquinolone, against methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 1998 Jun; 41: 655-8
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Davidson, R.J.1
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18
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Efficacy of BAY 12-8039 in Mycoplasma pneumoniae infected guinea pigs
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Sep 15; New Orleans
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Jacobs E, Dalhoff A, Brunner H. Efficacy of BAY 12-8039 in Mycoplasma pneumoniae infected guinea pigs [abstract]. 36th ICAAC; 1996 Sep 15; New Orleans, 102
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Jacobs, E.1
Dalhoff, A.2
Brunner, H.3
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19
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0003208416
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Sep; New Orleans
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Rouse MS, Piper KE, Patel R, et al. In vitro and in vivo activity of BAY 12-8039 or trovafloxacin against penicillin-resistant Streptococcus pneumoniae experimental pneumonia in immunocompetent mice [abstract]. 36th ICAAC 1996 Sep 15; New Orleans: 29
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Rouse, M.S.1
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20
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0003078692
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Ffficacy of BAY 12-8039, a potent new quinolone, in mouse models of typical and atypical respiratory infection
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Sep; New Orleans
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Waterbury K, Wang JJ, Barbiero M, et al. Ffficacy of BAY 12-8039, a potent new quinolone, in mouse models of typical and atypical respiratory infection [abstract]. 36th ICAAC 1996 Sep 15; New Orleans: 103
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Waterbury, K.1
Wang, J.J.2
Barbiero, M.3
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21
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0013627567
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In vivo activity of BAY 12-8039, a new 8-methoxy-quinolone, in a mouse model of tuberculosis
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Sep; San Diego
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Miyazaki E, Chaisson RE, Bishai WR. In vivo activity of BAY 12-8039, a new 8-methoxy-quinolone, in a mouse model of tuberculosis [abstract]. 38th ICAAC 1998; Sep 24; San Diego: 230
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38th ICAAC
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, pp. 230
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Miyazaki, E.1
Chaisson, R.E.2
Bishai, W.R.3
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22
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Moxifloxacin in the therapy of experimental pneumococcal meningitis
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Jun
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Schmidt H, Dalhoff A, Stuertz K, et al. Moxifloxacin in the therapy of experimental pneumococcal meningitis. Antimicrob Agents Chemother 1998 Jun; 42: 1397-401
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Schmidt, H.1
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23
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Evaluation of moxifloxacin, a new 8-methoxyquinolone, for treatment of meningitis caused by a penicillin-resistant Pneumococcus in rabbits
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Jul
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Ostergaard C, Sorensen TK, Knudsen JD, et al. Evaluation of moxifloxacin, a new 8-methoxyquinolone, for treatment of meningitis caused by a penicillin-resistant Pneumococcus in rabbits. Antimicrob Agents Chemother 1998 Jul; 42: 1706-12
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Ostergaard, C.1
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24
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0013572881
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Dalhoff A. Dissociated resistance among quinolones. Poster presented at ICIDs 1998; May 15-18; Boston
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Dalhoff, A.1
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25
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Souli M, Wennersten CB, Eliopoulos GM. In vitro activity of BAY 12-8039, a new fluoroquinolone against species representative of respiratory tract pathogens. Int J Antimicrob Agents 1998; 10 (1): 23-30
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Souli, M.1
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26
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0013606680
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In vitro activity of BAY 12-8039 against fluoroquinolone-resistant Gram negative bacilli and Enterococcus faecalis
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Poster presented; Sep 28; Toronto
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Tankovic J, Bechoual R, Leclercq L, et al. In vitro activity of BAY 12-8039 against fluoroquinolone-resistant Gram negative bacilli and Enterococcus faecalis. Poster presented at the 37th ICAAC; 1997 Sep 28; Toronto, 169
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Tankovic, J.1
Bechoual, R.2
Leclercq, L.3
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27
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15444352824
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Relationship between ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin (BAY 12-8039) MICs and mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus
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Apr
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Schmitz F-J, Hofmann B, Hansen B, et al. Relationship between ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin (BAY 12-8039) MICs and mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus. J Antimicrob Chemother 1998 Apr; 41: 481-4
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J Antimicrob Chemother
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Schmitz, F.-J.1
Hofmann, B.2
Hansen, B.3
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28
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0000140393
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Lack of in vivo emergence of resistance against BAY 12-08039 in Staph. aureus and Strep. pneumoniae
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May
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Dalhoff A, Heidtmann M, Obertegger S, et al. Lack of in vivo emergence of resistance against BAY 12-08039 in Staph. aureus and Strep. pneumoniae [abstract]. 8th ICIDs 1998; May 15: 124
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8th ICIDs
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Dalhoff, A.1
Heidtmann, M.2
Obertegger, S.3
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29
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0031903272
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Pharmacokinetics, safety, and tolerability of ascending single doses of moxifloxacin, a new 8-methoxy quinolone, administered to healthy subjects
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Aug
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Stass H, Dalhoff A. Kubitza D, et al. Pharmacokinetics, safety, and tolerability of ascending single doses of moxifloxacin, a new 8-methoxy quinolone, administered to healthy subjects. Antimicrob Agents Chemother 1998 Aug; 42: 2060-5
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Stass, H.1
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Kubitza, D.3
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30
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Pharmacokinetics (PK) and tolerability of the new methoxyquinolone BAY 12-8039: 10 Days treatment at 400 mg daily
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Poster presented; May; Lausanne
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Sullivan JT, Woodruff M, Lettieri J, et al. Pharmacokinetics (PK) and tolerability of the new methoxyquinolone BAY 12-8039: 10 days treatment at 400 mg daily. Poster presented at the 8th ECCMID; 1997 25 May; Lausanne, 4
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, pp. 4
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Sullivan, J.T.1
Woodruff, M.2
Lettieri, J.3
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31
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0003357936
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Cross over study to assess absolute bioavailability (AB) and absorption characteristics (AC) of moxifloxacin in man
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Poster presented; May 15-18; Boston
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Stass HH. Kubitza D. Cross over study to assess absolute bioavailability (AB) and absorption characteristics (AC) of moxifloxacin in man. Poster presented at the 8th ICIDs; 1998 May 15-18; Boston
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8th ICIDs
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Stass, H.H.1
Kubitza, D.2
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32
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0013626174
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Comparison of skin blister fluid (SBF) and interstitial tissue kinetics of BAY 12-8039 in healthy volunteers (HV) using microdialysis (Mi)
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Sep 24; San Diego
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Stass H, Brunner M, Eichler HG, et al. Comparison of skin blister fluid (SBF) and interstitial tissue kinetics of BAY 12-8039 in healthy volunteers (HV) using microdialysis (Mi) [abstract]. 38th ICAAC; 1998 Sep 24; San Diego, 4
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(1998)
38th ICAAC
, pp. 4
-
-
Stass, H.1
Brunner, M.2
Eichler, H.G.3
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34
-
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0001887094
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Penetration of Bay 12-8039 into bronchial mucosa, epithelial lining
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Sep, San Diego
-
Andrews J, Honeybourne D, Jevons G, et al. Penetration of Bay 12-8039 into bronchial mucosa, epithelial lining [abstract]. 38th ICAAC; 1998 Sep, San Diego 24, 9
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(1998)
38th ICAAC
, pp. 24
-
-
Andrews, J.1
Honeybourne, D.2
Jevons, G.3
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35
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0000174362
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Penetration of moxifloxacin (MFX) into sinus tissues following multiple oral dosing
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Mar 21-24, Berlin
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Gehanno P, Stass H, Arvis P. Penetration of moxifloxacin (MFX) into sinus tissues following multiple oral dosing. Abstract accepted by 9th ECCMID; 1999 Mar 21-24, Berlin
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(1999)
9th ECCMID
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Gehanno, P.1
Stass, H.2
Arvis, P.3
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36
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0000144810
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BAY 12-8039, a new 8-methoxyquinolone: Investigations on distribution in rats
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Sep 28; Toronto
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Siefert HM, Daehler HP, Goeller G, et al. BAY 12-8039, a new 8-methoxyquinolone: investigations on distribution in rats [abstract]. 37th ICAA; 1997 Sep 28; Toronto, 171
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37th ICAA
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-
Siefert, H.M.1
Daehler, H.P.2
Goeller, G.3
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37
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0013600737
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BAY 12-8039, a new 8-methoxy-quinolone: Pharmacokinetics in rats and monkeys
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Sep 15; New Orleans
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Siefert HM, Bühner K, Domdey-Bette A, et al. BAY 12-8039, a new 8-methoxy-quinolone: pharmacokinetics in rats and monkeys [abstract]. 36th ICAAC 1996 Sep 15; New Orleans: 103
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36th ICAAC
, pp. 103
-
-
Siefert, H.M.1
Bühner, K.2
Domdey-Bette, A.3
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38
-
-
0013573306
-
-
Data on File, Bayer
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Data on file, Bayer.
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-
-
-
39
-
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0002635950
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BAY 12-8039, a new 8-methoxy-quinolone: Metabolism in rat, monkey, and man
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Sep 15; New Orleans
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Kern A, Kanhai W, Fröhde R, et al. BAY 12-8039, a new 8-methoxy-quinolone: metabolism in rat, monkey, and man [abstract]. 36th ICAAC; 1996 Sep 15; New Orleans, 103
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36th ICAAC
, pp. 103
-
-
Kern, A.1
Kanhai, W.2
Fröhde, R.3
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40
-
-
0002635948
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BAY 12-8039 (1), a new 8-methoxy-quinolone: Safety (S), tolerability and steady state pharmacokinetics (PK) in healthy male volunteers
-
Sep 15; New Orleans
-
Kubitza D, Stass HH, Wingender W, et al. BAY 12-8039 (1), a new 8-methoxy-quinolone: safety (S), tolerability and steady state pharmacokinetics (PK) in healthy male volunteers [abstract]. 36th ICAAC; 1996 Sep 15; New Orleans, 104
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(1996)
36th ICAAC
, pp. 104
-
-
Kubitza, D.1
Stass, H.H.2
Wingender, W.3
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42
-
-
0002705616
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No dose adjustment needed for patients with renal impairment receiving oral BAY 12-8039 (M)
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Sep 24; San Diego
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Stass H, Halabi A, Delesen H. No dose adjustment needed for patients with renal impairment receiving oral BAY 12-8039 (M) [abstract]. 38th ICAAC; 1998 Sep 24; San Diego, 5
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(1998)
38th ICAAC
, pp. 5
-
-
Stass, H.1
Halabi, A.2
Delesen, H.3
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43
-
-
0013573067
-
-
Data on file, Bayer
-
Data on file, Bayer.
-
-
-
-
44
-
-
0013625074
-
Moxifloxacin (MFX) versus amoxicillin (AMOX) in the treatment of community-acquired suspected pneumococcal pneumonia: A multinational double-blind randomised study
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Mar 21-24, Berlin
-
Petipretz P, Branco Pires J, Dosedel J, et al. Moxifloxacin (MFX) versus amoxicillin (AMOX) in the treatment of community-acquired suspected pneumococcal pneumonia: a multinational double-blind randomised study. Abstract accepted by 9th ECCMID; 1999 Mar 21-24, Berlin
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(1999)
9th ECCMID
-
-
Petipretz, P.1
Branco Pires, J.2
Dosedel, J.3
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45
-
-
0002647816
-
Moxifloxacin (MFX) in community-acquired pneumonia - A bacteriological and clinical meta-analysis
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Poster (#PO205)) accepted; Mar 21-24, Berlin
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Krasemann C. Meyer JM, Springkslee M. Moxifloxacin (MFX) in community-acquired pneumonia - a bacteriological and clinical meta-analysis. Poster (#PO205)) accepted by 9th ECCMID; 1999 Mar 21-24, Berlin
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(1999)
9th ECCMID
-
-
Krasemann, C.1
Meyer, J.M.2
Springkslee, M.3
-
46
-
-
0013573487
-
Short-course moxifloxacin (MFX) vs clarithromycin (CLAR) in acute exacerbations of chronic bronchitis (AECB)
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Poster (#PO209) accepted; Mar 21-24, Berlin
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Wilson R, Kubin R. Short-course moxifloxacin (MFX) vs clarithromycin (CLAR) in acute exacerbations of chronic bronchitis (AECB). Poster (#PO209) accepted by 9th ECCMID; 1999 Mar 21-24, Berlin
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(1999)
9th ECCMID
-
-
Wilson, R.1
Kubin, R.2
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47
-
-
0002647816
-
Moxifloxacin (MFX) in acute exacerbations of chronic bronchitis - A bacteriological and clinical meta-analysis
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Poster (#PO2031) accepted; Mar 21-24, Berlin
-
Krasemann C, Meyer JM, Springsklee M. Moxifloxacin (MFX) in acute exacerbations of chronic bronchitis - a bacteriological and clinical meta-analysis. Poster (#PO2031) accepted by 9th ECCMID; 1999 Mar 21-24, Berlin
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(1999)
9th ECCMID
-
-
Krasemann, C.1
Meyer, J.M.2
Springsklee, M.3
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49
-
-
0013625075
-
Moxifloxacin in acute sinusitis - A bacteriological and clinical meta-analysis
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Poster (#PO204) accepted; Mar 21-29, Berlin
-
Krasemann C, Meyer JM, Springsklee M. Moxifloxacin in acute sinusitis - a bacteriological and clinical meta-analysis. Poster (#PO204) accepted by 9th ECCMID; 1999 Mar 21-29, Berlin
-
(1999)
9th ECCMID
-
-
Krasemann, C.1
Meyer, J.M.2
Springsklee, M.3
-
50
-
-
0000290841
-
Safety and tolerability profile of MFX
-
Poster (#PO208) accepted; Mar 21-29, Berlin
-
Springsklee M, Reiter C, Meyer JM. Safety and tolerability profile of MFX. Poster (#PO208) accepted by 9th ECCMID; 1999 Mar 21-29, Berlin
-
(1999)
9th ECCMID
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-
Springsklee, M.1
Reiter, C.2
Meyer, J.M.3
-
51
-
-
0001937991
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Safety of the new quinolone BAY 12-8039 in 130 healthy volunteers
-
Jun 29; Sydney
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