Continuous, combined hormone replacement: Randomized comparison of transdermal and oral preparations

Obstetrics and Gynecology

Volumn 94, Issue 1, 1999, Pages 61-65

  Mattsson, Lars A ^a   Bohnet, Heinz G ^b   Gredmark, Thomas ^a   Torhorst, Joachim ^b   Hornig, Friedhelm ^c   Hüls, Gabriele ^c  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF BASEL   (Switzerland)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; NORETHISTERONE ACETATE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; EARLY DIAGNOSIS; ENDOMETRIUM HYPERPLASIA; ESTROGEN DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; MAJOR CLINICAL STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSDERMAL DRUG ADMINISTRATION; TREATMENT INDICATION; TREATMENT OUTCOME; UTERUS BLEEDING;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ADULT; AGED; DRUG THERAPY, COMBINATION; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; MIDDLE AGED; NORETHINDRONE;

EID: 0032982385     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0029-7844(99)00225-2     Document Type: Article

References (18)

1. Henderson B.E. The cancer question An overview of recent epidemiologic and retrospective data . Am J Obstet Gynecol. 161:1989;1859-1864.
2. Cauley J.A., Seeley D.G., Browner W.S., Ensrud K., Kuller L.H., Lipschutz R.C., et al. Estrogen replacement therapy and mortality among older women. Arch Intern Med. 157:1997;2181-2187.
3. Grey A.B., Cundy T.F., Reid I.R. Continuous combined oestrogen/progestin therapy is well tolerated and increases bone density at the hip and spine in post-menopausal osteoporosis. Clin Endocrinol (Oxf). 40:1994;671-677.
4. Stadberg E., Mattsson L.A., Uvebrant M. 17 beta-estradiol and norethisterone acetate in low doses as continuous combined hormone replacement therapy. Maturitas. 23:1996;31-39.
5. Evans S.F., Davie M.W. Low and conventional dose transdermal oestradiol are equally effective at preventing bone loss in spine and femur at all post-menopausal ages. Clin Endocrinol (Oxf). 44:1996;79-84.
6. Stadberg E., Mattsson L.A., Milsom I. Women's attitudes and knowledge about the climacteric period and its treatment. A Swedish population-based study. Maturitas. 27:1997;109-116.
7. Mattsson L.A., Cullberg G., Samsioe G. Evaluation of a continuous oestrogen-progestogen regimen for climacteric complaints. Maturitas. 4:1982;95-102.
8. Marslew U., Riis B.J., Christiansen C. Bleeding patterns during continuous combined estrogen-progestogen therapy. Am J Obstet Gynecol. 164:1991;1163-1168.
9. Bewtra C., Kable W.T., Gallagher J.C. Endometrial histology and bleeding patterns in menopausal women treated with estrogen and continuous or cyclic progestin. J Reprod Med. 33:1988;205-208.
10. Cheang A., Sitruk-Ware R., Utian W.H. A risk-benefit appraisal of transdermal estradiol therapy. Drug Saf. 9:1993;365-379.
11. Mattsson L.Å., Samsioe G., von Schoultz B., Uvebrant M., Wiklund I. Transdermally administered oestradiol combined with oral medroxyprogesterone acetate The effects on lipoprotein metabolism in postmenopausal women . Br J Obstet Gynaecol. 100:1993;450-453.
12. Wiklund I., Karlberg J., Lindgren R., Sandin K., Mattsson L.-A. A Swedish version of the women's health questionnaire. A measure of postmenopausal complaints. Acta Obstet Gynecol Scand. 72:1993;648-655.
13. Mazur H.T., Kurman R.J. Diagnosis of endometrial biopsies and curettings. 1994;Springer, New York.
14. Woodruff J.D., Pickar J.H. Incidence of endometrial hyperplasia in postmenopausal women taking conjugated estrogens (Premarin) with medroxyprogesterone acetate or conjugated estrogens alone. The Menopause Study Group. Am J Obstet Gynecol. 170:1994;1213-1223.
15. Archer D.F., McIntyre-Seltman K., Wilborn W.W. Jr, Dowling E.A., Cone F., Creasy G.W., et al. Endometrial morphology in asymptomatic postmenopausal women. Am J Obstet Gynecol. 165:1991;317-322.
16. Varner R.E., Sparks J.M., Cameron C.D., Roberts L.L., Soong S.J. Transvaginal sonography of the endometrium in postmenopausal women. Obstet Gynecol. 78:1991;195-199.
17. Magos A.L., Brincat M., Studd J.W., Wardle P., Schlesinger P., O'Dowd T. Amenorrhea and endometrial atrophy with continuous oral estrogen and progestogen therapy in postmenopausal women. Obstet Gynecol. 65:1985;496-499.
18. Sporrong T., Hellgren M., Samsioe G., Mattsson L.A. Comparison of four continuously administered progestogen plus oestradiol combinations for climacteric complaints. Br J Obstet Gynaecol. 5:1988;1042-1048.