Recall antigen presentation by γ-interferon-activated microglia results in T cell activation and propagation of the immune response

Journal of Neuroimmunology

Volumn 98, Issue 2, 1999, Pages 105-111

  Hall, Gillian L ^a,b   Girdlestone, John ^c   Compston, D Alastair S ^a,b   Wing, Mark G ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Forvie Site   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Antigen presentation; Microglia; Rodent; T cells

Indexed keywords

ANTIGEN; CYTOKINE; GAMMA INTERFERON;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; IMMUNE RESPONSE; MICROGLIA; MIXED LYMPHOCYTE REACTION; NEWBORN; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

EID: 0032981190     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00069-7     Document Type: Article

References (36)

1. Cash E., Rott O. Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system. Clin. Exp. Imuunol. 98:1995;313-318.
2. Cash E., Zhan Y., Rott O. Microglia present myelin antigens to T cells after phagocytosis of oligodendrocytes. Cell. Immunol. 147:1993;129-138.
3. Chambers C.A., Allison J.P. Co-stimulation in T cell responses. Curr. Opin. Immunol. 9:1997;369-404.
4. De Simone R., Giampaolo A., Giometto B., Gallo P., Levi G., Peschle C., Aloisi F. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J. Neuropathol. Exp. Neurol. 54:1995;175-187.
5. Dubey C., Croft M., Swain S.L. Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals. J. Immunol. 157:1996;3280-3289.
6. Fontana A., Fierz W., Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature. 307:1984;273-276.
7. Ford A.L., Foulcher E., Lemckert F.A., Sedgewick J.D. Microglia induce CD4 T lymphocyte final effector function and death. J. Exp. Med. 184:1996;1737-1745.
8. Frei K., Siepl C., Groscurth P., Bodmer S., Schwerdel C., Fontana A. Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells. Eur. J. Immunol. 17:1987;1271-1278.
9. Girdlestone J., Wing M. Autocrine activation by interferon-gamma of STAT factors following T cell activation. Eur. J. Immunol. 26:1996;704-709.
10. Giulian D., Baker T.J. Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6:1986;2163-2178.
11. Hall G.L., Wing M.G., Compston D.A.S., Scolding N.J. β-interferon regulates the immunomodulatory activity of neonatal rodent microglia. J. Neuroimmunol. 72:1997;11-19.
12. Hashim G.A. Myelin basic protein: structure, function and antigenic determinants. Immunol. Rev. 39:1978;60.
13. Hickey W.F., Kimura H. Perivascular microglia cells of the CNS are bone marrow-derived and present antigen in vivo. Science. 239:1988;290-292.
14. Jenkins M.K., Schwartz R.H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:1987;302-319.
15. Jenkins M.K., Chen C., Jung G., Mueller D.L., Schwartz R.H. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J. Immunol. 144:1990;16-22.
16. June C.H., Bluestone J.A., Nadler L.M., Thompson C.B. The B7 and CD28 receptor families. Immunol. Today. 15:1994;321-331.
17. Kohji T., Tanuma N., Aikawa Y., Kawazoe Y., Suzuki Y., Kohyama K., Matsumoto Y. Interaction between apoptotic cells and reactive brain cells in the central nervous system of rats with autoimmune encephalomyelitis. J. Neuroimmunol. 82:1998;168-174.
18. Matsumoto Y., Ohmori K., Fujiwara M. Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions. Immunology. 76:1992;209-216.
19. Matsumoto Y., Hanawa H., Tsuchida M., Abo T. In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis. Immunology. 79:1993;381-390.
20. Mueller D.L., Jenkins M.K., Schwartz R.H. An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness. J. Immunol. 142:1989;2617-2628.
21. Nikcevich K.M., Gordon K.B., Tan L., Hurst S.D., Kraepfl J.F., Gardinier M., Barrett T.A., Miller S.D. IFN-γ-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells. J. Immunol. 158:1997;614-621.
22. Pender, M.P., 1993. Apoptosis in the target organ of an autoimmune disease. In: Lavin, M., Watters, D. (Eds.), Programmed Cell Death: The Cellular and Molecular Biology of Apoptosis. Harwood Academic Publishers, Chur, Switzerland, pp. 235-244.
23. Pender M.P., Nguyen K.B., McCombe P.A., Kerr J.F.R. Apoptosis in the nervous system in experimental allergic encephalomyelitis. J. Neurosci. 104:1991;81-87.
24. Pender M.P., McCombe P.A., Yoong G., Nguyen K.B. Apoptosis of αβ T lymphocytes in the nervous system in experimental autoimmune encephalomyelitis: its possible implications for recovery and acquired tolerance. J. Autoimmunol. 5:1992;401-410.
25. Quill H., Schwartz R.H. Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferation nonresponsiveness. J. Immunol. 138:1987;3704-3712.
26. Raine C.S. Multiple sclerosis: a pivotal role for the T cell in lesion development. Neuropathol. Appl. Neurobiol. 17:1991;265-274.
27. Sadowski H.B., Shuai K., Darnell J.E. Jr., Gilman M.Z. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science. 261:1993;1739-1744.
28. Scala G., Oppenheim J.J. Antigen presentation by human monocytes: evidence for stimulant processing and requirement for interleukin 1. J. Immunol. 131:1983;1160-1166.
29. Schmied M., Breitschopf H., Gold R., Zischler H., Rothe G., Wekerle H., Lassman H. Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am. J. Pathol. 143:1993;446-452.
30. + encephalitogenic T cells. Eur. J. Immunol. 24:1994;2609-2617.
31. Ulvestad E., Wiliiams K., Bo L., Trapp B., Antel J., Mork S. HLA class II molecules (HLA-DR, -DP,-DQ) on cells in the human CNS studied in situ and in vitro. Immunology. 82:1994;535-541.
32. Weber F., Meinl E., Aloisi F., Nevinny-Stickel C., Albert E., Werkle H., Hohlfeld R. Human astrocytes are only partially competent antigen presenting cells. Possible implications for lesion development in multiple sclerosis. Brain. 117:1994;59-69.
33. Williams K., Ulvestad E., Cragg L., Blain M., Antel J.P. Induction of primary T cell responses by human glial cells. J. Neurosci. Res. 36:1993;382-390.
34. Williams K., Ulvestad E., Antel J.P. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ. Eur. J. Immunol. 24:1994;3031-3037.
35. Woodroofe M.N., Hayes G.M., Cuzner M.L. Fc receptor density, MHC antigen expression and superoxide production are increased in interferon-γ-treated microglia isolated from adult rat brain. Immunology. 68:1989;421-426.
36. Zajicek J.P., Wing M.G., Scolding N.J., Compston D.A.S. Interactions between oligodendrocytes and microglia. Brain. 115:1992;1611-1631.