Evaluating the delivery of nebulized and metered-dose inhalers in an in vitro infant ventilator lung model

Annals of Pharmacotherapy

Volumn 33, Issue 2, 1999, Pages 144-148

  Avent, Minyon L ^a,b   Gal, Peter ^c   Ransom, J Laurence ^d   Brown, Yvonne L ^d   Hansen, Charles J ^d   Ricketts, William A ^d   Soza, Feliza ^d  

^a The Women's Hospital of Greensboro   (United States)

^b BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d NONE

Author keywords

Albuterol metered dose inhaler, nebulized; Beclomethasone diproprionate, metered dose inhaler, pediatrics

Indexed keywords

BECLOMETASONE DIPROPIONATE; SALBUTAMOL; SALBUTAMOL SULFATE;

ARTICLE; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG FORMULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUNG MODEL; METERED DOSE INHALER; NEBULIZATION; NEBULIZER; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; VENTILATOR;

ALBUTEROL; BECLOMETHASONE; BRONCHODILATOR AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EVALUATION STUDIES; HUMANS; INFANT; MODELS, BIOLOGICAL; NEBULIZERS AND VAPORIZERS; VENTILATORS, MECHANICAL;

EID: 0032980469     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.17426     Document Type: Article

References (39)

1. Wilkie RA, Bryan MH. Effect of bronchodilators on airway resistance in ventilator-dependent neonates with chronic lung disease. J Pediatr 1987; 111:278-282.
2. Prendiville A, Green S, Silverman M. Ipratropium bromide and airways function in wheezy infants. Arch Dis Child 1987;62:397-400.
3. Brundage KL, Mohsini KG, Froese AB, Fisher JT. Bronchodilator response to ipratropium bromide in infants with bronchopulmonary dysplasia. Am Rev Respir Dis 1990;142:1137-42.
4. Denjean A, Guimaraes H, Migdal M, Miramand JL, Dehan M, Gaultier C. Dose-related bronchodilator response to aerosolized salbutamol (albuterol) in ventilator-dependent premature infants. J Pediatr 1992;120: 974-9.
5. Rotschild A, Solimano A, Puterman M, Smyth J, Sharma A, Albersheim S. Increased compliance in response to salbutamol in premature infants with developing bronchopulmonary dysplasia. J Pediatr 1989;115:984-91.
6. Watterberg KL, Clark AR, Kelly HW, Murphy S. Delivery of aerosolized medication to intubated babies. Pediatr Pulmunol 1991;10:136-41.
7. Newman S. Aerosol deposition considerations in inhalation therapy. Chest 1985;88(suppl):152S-60S.
8. Fuller HD, Dolovich MB, Posmituck G, Wong Pack W, Newhouse MT. Pressurised aerosol versus jet aerosol delivery to mechanically ventilated patients. Am Rev Respir Dis 1990;141:440-4.
9. MacIntyre NR, Silver RM, Miller CW, Schuler F, Coleman RE. Aerosol delivery in intubated, mechanically ventilated patients. Crit Care Med 1985;13:81-4.
10. Fraser I, DuVall A, Dolovich M, Newhouse MT. Therapeutic aerosol delivery in ventilator systems (abstract). Am Rev Respir Dis 1981;123:107.
11. Cameron D, Arnot R, Clay M, Silverman M. Aerosol delivery in neonatal ventilator circuits: a rabbit lung model. Pediatr Pulmonol 1991;10: 208-13.
12. O'Callaghan C, Hardy J, Stammers J, Stephenson TJ, Hull D. Evaluation of techniques for delivery of steroids to lungs of neonates using a rabbit model. Arch Dis Child 1992;67:20-4.
13. Flavin M, MacDonald M, Dolovich M, Coates G, O'Brodovich H. Aerosol delivery to the rabbit lung with an infant ventilator. Pediatr Pulmonol 1986;2:35-9.
14. Banks J, Levenson H, Cvetnic W, Naglie R, Zenk K, Hallman M. Pulmonary aerosol deposition in the mechanically ventilated newborn piglet (abstract). Clin Res 1990;38:201 A.
15. Jenkins SC, Heaton RW, Fulton TJ, Moxham J. Comparison of domiciliary nebulized salbutamol and salbutamol from a metered-dose inhaler in stable chronic airflow limitation. Chest 1987;91:804-7.
16. Summer W, Elslon R, Tharpe L, Nelson S, Haponik EF. Aerosol bronchodilator delivery methods: relative impact on pulmonary function and cost of respiratory care. Arch Intern Med 1989;149:618-23.
17. Jasper AC, Mohsenifar Z, Kahan S, Goldberg HS, Koerner SK. Cost-benefit comparison of aerosol bronchodilator delivery methods in hospitalized patients. Chest 1987;91:614-9.
18. Turner JR, Corkery KJ, Eckman D, Gelb AM, Lipavsky A, Sheppard D. Equivalence of continuous flow nebulizer and metered-dose inhaler with reservoir bag for treatment of acute airflow obstruction. Chest 1988;93: 476-81.
19. Christensson P, Arborelius M, Lilja B. Salbutamol inhalation in chronic asthma bronchiale: dose aerosol versus jet nebulizer. Chest 1981;79:416-9.
20. Gay PC, Patel HG, Nelson SB, Gilles B, Hubmayr RD. Metered dose inhalers for bronchodilator delivery in intubated, mechanically ventilated patients. Chest 1991;99:66-71.
21. Mestitz H, Copland JM, McDonald CF. Comparison of outpatient nebulized vs metered dose inhaler terbutaline in chronic airflow obstruction. Chest 1989;96:1237-40.
22. Lee H, Arnon S, Silverman M. Bronchodilator aerosol administered by metered dose inhaler and spacer in subacute neonatal respiratory distress syndrome. Arch Dis Child 1994;70(suppl):F218-F222.
23. Benson JM, Gal P, Kandrotas RJ, Watling SM, Hansen CJ. The impact of changing ventilator parameters on availability of nebulized drugs in an in vitro neonatal lung system. DICP Ann Pharmacother 1991;25:272-5.
24. Grigg J, Arnon S, Jones T, Clarke A, Silverman M. Delivery of therapeutic aerosols to intubated babies. Arch Dis Child 1992;67:25-30.
25. Coleman DM, Kelly HW, McWilliams BC. Determinants of aerosolized albuterol delivery to mechanically ventilated infants. Chest 1996;109: 1607-13.
26. Dhand R, Tobin MJ. Bronchodilator delivery with metered-dose inhalers in mechanically-ventilated patients. Eur Respir J 1996;9:585-95.
27. Manthous CA, Hall JB, Schmidt GA, Wood LDH. Metered-dose inhaler versus nebulized albuterol in mechanically ventilated patients. Am Rev Respir Dis 1993;148:1567-70.
28. Rau JL, Harwood RJ, Groff JL. Evaluation of a reservoir device for metered-dose bronchodilator delivery to intubated adults: an in vitro study. Chest 1992;102:924-30.
29. Everard ML, Stammers J, Hardy JG, Milner AD. New aerosol delivery system for neonatal ventilator circuits. Arch Dis Child 1992;67:826-30.
30. Kraemer R, Birrer P, Modelska K, Aebischer C, Schöni MH. A new baby-spacer device for aerosolized bronchodilator administration in infants with bronchopulmonary disease. Eur J Pediatr 1992;151:57-60.
31. Ebert J, Adams AB, Green-Aide B. An evaluation of MDI spacers and adapters: their effect on the respirable volume of medication. Respir Care 1992;37:862-8.
32. Avent ML, Gal P, Ransom JL, Brown YL, Hansen CJ. Comparing the delivery of albuterol metered-dose inhaler via an adapter and spacer device in an in vitro infant ventilator lung model. Ann Pharmacother 1999; 33:141-3.
33. Hughes JM, Saez J. Effects of nebulizer mode and position in a mechanical ventilator circuit on dose efficiency. Respir Care 1987;32:1131-5.
34. O'Doherty MJ, Thomas SHL, Page CJ, Treacher DF, Nunan TO. Delivery of a nebulized aerosol to a lung model during mechanical ventilation: effect of ventilator settings and nebulizer type, position, and volume of fill. Am Rev Respir Dis 1992;146:383-8.
35. Malone RA, Hollie MC, Glynn-Barnhart A, Nelson HS. Optimal duration of nebulized albuterol therapy. Chest 1993;104:1114-8.
36. Garner SS, Wiest DB, Bradley JW, Lesher BA, Habib DM. Albuterol delivery by metered-dose inhaler in a mechanically ventilated pediatric lung model. Crit Care Med 1996;24:870-4.
37. O'Riordan TG, Greco MJ, Perry RJ, Smaldone GC. Nebulizer function during mechanical ventilation. Am Rev Respir Dis 1992;145:1117-22.
38. Fink JB, Dhand R, Duarte AG, Jenne JW, Tobin MJ. Aerosol delivery from a metered-dose inhaler during mechanical ventilation. Am J Respir Crit Care Med 1996;154:382-7.
39. Cameron D, Clay M, Silverman M. Evaluation of nebulizers for use in neonatal ventilator circuits. Crit Care Med 1990;18:866-70.