Characterisation of kainate receptor mediated whole-cell currents in rat cultured cerebellar granule cells

Neuropharmacology

Volumn 38, Issue 3, 1999, Pages 375-382

  Savidge, Jonathan R ^a   Sturgess, Nicholas C ^b   Bristow, David R ^a   Lock, Edward A ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

(2S, 4R) 4 methyl glutamate; AMPA receptor; Cerebellar granule cell; Concanavalin A; Cyclothiazide; GYKI 53655; Kainate receptor

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 4 METHYLGLUTAMIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CONCANAVALIN A; KAINIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CEREBELLUM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GRANULE CELL; MEMBRANE CURRENT; NONHUMAN; PRIORITY JOURNAL; RAT; VOLTAGE CLAMP;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BENZODIAZEPINES; BENZOTHIADIAZINES; CELLS, CULTURED; CONCANAVALIN A; EVOKED POTENTIALS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMATES; HIPPOCAMPUS; KINETICS; NEURONS; NEUROTOXINS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, KAINIC ACID; SPIDER VENOMS;

EID: 0032979771     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00202-0     Document Type: Article

References (35)

1. Bettler, B., Mulle, C., 1995. Review: neurotransmitter receptors II-AMPA and kainate receptors. Neuropharmacology 34, 123-139.
2. Blaschke, M., Keller, B.U., Rivosecchi, R., Hollmann, M., Heinemann, S., Konnerth, A., 1993. A single amino acid determines the subunit-specific spider toxin block of α-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels. Proc. Natl. Acad. Sci. USA 90, 6528-6532.
3. Bleakman, D., Ballyk, B.A., Schoepp, D.D., et al., 1996. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereo specificity and selectivity profiles. Neuropharmacology 35, 1689-1702.
4. Bowie, D., Mayer, M.L., 1995. Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block. Neuron 15, 453-462.
5. A receptor α1 subunit protein in rat cerebellar granule cells. Br. J. Pharmacol. 118, 1103-1110.
6. Burnashev, N., Zhou, Z., Neher, E., Sakmann, B., 1995. Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J. Physiol. 485, 403-418.
7. Castillo, P.E., Malenka, R.C., Nicoll, R.A., 1997. Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons. Nature 388, 182-186.
8. Clarke, V.R.J., Ballyk, B.A., Hoo, K.H., et al., 1997. A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389, 599-603.
9. Collingridge, G.L., Lester, R.A.S., 1989. Excitatory amino acid receptors in the vertebrate central nervous system. Pharm. Rev. 40, 143-210.
10. Fletcher, E.J., Lodge, D., 1996. New developments in the molecular pharmacology of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate and kainate receptors. Pharmacol. Ther. 70, 65-89.
11. Hamill, O.P., Marty, A., Neher, E., Sakmann, B., Sigworth, F.J., 1981. An improved patch clamp technique for high resolution current recordings from cell and cell-free membrane patches. Pflugers Arch. 391, 85-100.
12. Herb, A., Burnashev, N., Werner, P., Sakmann, B., Wisden, W., Seeburg, P.H., 1992. The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron 8, 775-785.
13. Huettner, J.E., 1990. Glutamate receptor channels in rat dorsal root ganglion neurons: activation by kainate and quisqualate and blockade of desensitisation by concanavalin A. Neuron 5, 255-266.
14. Jones, K.A., Wilding, T.J., Huettner, J.E., Costa, A.M., 1997. Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology 36, 853-863.
15. Kamboj, S.K., Swanson, G.T., Cull-candy, S., 1995. Intracellular spermine confers rectification on rat calcium-permeable AMPA and kainate receptors. J. Physiol. 486, 297-303.
16. Lerma, J., Paternain, A.V., Naranjo, J.R., Mellstrom, B., 1993. Functional kainate-selective glutamate receptors in cultured hippocampal neurons. Proc. Natl. Acad. Sci. USA 90, 11688-11692.
17. Lerma, J., 1997. Kainate reveals its targets. Neuron 19, 1155-1158.
18. Partin, K.M., Patneau, D.K., Winters, C.A., Mayer, M.L., Buonanno, A., 1993. Selective modulation of desensitisation at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11, 1069-1082.
19. Paternain, A.V., Morales, M., Lerma, J., 1995. Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 14, 185-189.
20. Pemberton, K.E., Belcher, S.M., Ripellino, J.A., Howe, J.R., 1998. High-affinity kainate-type ion channels in rat cerebellar granule cells. J. Physiol. 510, 401-420.
21. Rodriguez-Moreno, A., Herras, O., Lerma, J., 1997. Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. Neuron 19, 893-901.
22. Ruano, D., Lambolez, B., Rossier, J., Paternain, A.V., Lerma, J., 1995. Kainate receptor subunits expressed in single cultured hippocampal neurons: molecular and functional variants by RNA editing. Neuron 14, 1009-1017.
23. Sahara, Y., Noro, N., Iida, Y., Nakamura, Y., 1997. Glutamate receptor subunits GluR5 and KA-2 are coexpressed in rat trigeminal ganglion neurons. J. Neurosci. 17, 6611-6620.
24. Savidge, J.R., Bleakman, D., Bristow, D.R., 1997. Identification of kainate receptor-mediated intracellular calcium increases in cultured rat cerebellar granule cells. J. Neurochem. 69, 1763-1766.
25. Savidge, J.R., Bristow, D.R., 1998. Calcium permeability and joro spider toxin sensitivity of AMPA- and kainate-receptors on cerebellar granule cells. Eur. J. Pharmacol. 351, 131-138.
26. Savidge, J.R., Sturgess, N.C., Bristow, D.R., Lock, E.A., 1998. Discrimination of whole-cell currents mediated by AMPA- and kainate-type glutamate receptors in rat cultured cerebellar granule cells. Br. J. Pharmacol. 124, 131P.
27. Schiffer, H.H., Swanson, G.T., Heinemann, S.F., 1997. Rat GluR7 and a carboxy-termial splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate. Neuron 19, 1141-1146.
28. Sommer, B., Kohler, M., Sprengel, R., Seeburg, P.H., 1991. RNA editing in brain controls a determinant of ion flow in glutamategated channels. Cell 67, 11-19.
29. Stein, E., Cox, J.A., Seeburg, P.H., Verdoorn, T.A., 1992. Complex pharmacological properties of recombinant α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes. Mol. Pharmacol. 42, 864-871.
30. Swanson, G.T., Feldmeyer, D., Kaneda, M., Cull-Candy, S., 1996. Effect of RNA editing and subunit co-assembly on single-channel properties of recombinant kainate receptors. J. Physiol. 492, 129-142.
31. 3H](2S,4R)-4-methylglutamate: pharmacological characterization in rabbit brain membranes. Neuropharmacology 36, 1483-1488.
32. Vignes, M., Collingridge, G.L., 1997. The synaptic activation of kainate receptors. Nature 388, 179-182.
33. Wilding, T.J., Huettner, J.E., 1995. Differential antagonism of α-amino-3-hydroxy-5-methyl-4-ioxazolepropionic acid-preferring and kainate-preferring by 2,3-benzodiazepines. Mol. Pharmacol. 47, 582-587.
34. Wilding, T.J., Huettner, J.E., 1996. Antagonist pharmacology of kainate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring receptors. Mol. Pharmacol. 49, 540-546.
35. Zhou, L.M., Gu, Z.Q., Costa, A.M., Yamada, K.A., Mansson, P.E., Giordano, T., Skolnick, P., Jones, K.A., 1997. (2S,4R)-4-Methylglutamic acid (SYM 2081): a selective, high affinity ligand for kainate receptors. J. Pharmacol. Exp. Ther. 280, 422-427.