Comparison of efficacies of oral levofloxacin and oral ciprofloxacin in a rabbit model of a staphylococcal abscess

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 3, 1999, Pages 667-671

  Fernandez, Jeffrey ^a   Barrett, John F ^a,b   Licata, Lisa ^a   Amaratunga, Dhammika ^a   Frosco, Marybeth ^a,b  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; LEVOFLOXACIN;

ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BACTERIAL COUNT; CELL VIABILITY; COMPARATIVE STUDY; CONCENTRATION RESPONSE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG EFFICACY; FEMALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RABBIT; SKIN ABSCESS; STAPHYLOCOCCUS AUREUS;

EID: 0032979650     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.3.667     Document Type: Article

References (12)

1. Bamberger, D. M., M. T. Fields, and B. L. Herndon. 1991. Efficacies of various antimicrobial agents in treatment of Staphylococcus aureus abscesses and correlation with in vitro tests of antimicrobial activity and neutrophil killing. Antimicrob. Agents Chemother. 35:2335-2339.
2. Bamberger, D. M., B. L. Herndon, M. Dew, R. P. Chern, H. Mitchell, L. E. Summers, R. F. Marcus, S. C. Kim, and P. R. Suvarna. 1997. Efficacies of ofloxacin, rifampin, and clindamycin in treatment of Staphylococcus aurais abscesses and correlation with results of an in vitro assay of intracellular bacterial killing. Antimicrob. Agents Chemother. 41:1178-1181.
3. Bamberger, D. M., B. L. Herndon, and P. R. Suvarna. 1995. Azithromycin in an experimental Staphylococcus aureus abscess model. J. Antimicrob. Chemother. 35:623-629.
4. Bamberger, D. M., L. R. Peterson, D. N. Gerding, J. A. Moody, and C. E. Fasching. 1986. Ciprofloxacin, azlocillin, ceftizoxime and amikacin alone and in combination against gram negative bacilli in an infected chamber model. J. Antimicrob. Chemother. 18:51-63.
5. Chien, S. C., M. C. Rogge, L. G. Gisclon, C. Curtin, F. Wong, J. Nalarajan, R. R. Williams, C. L. Fowler, W. K. Cheung, and A. T. Chow. 1997. Pharmacokinetic profile of levofloxacin following once-daily 500-milligram oral or intravenous doses. Antimicrob. Agents Chemother. 41:2256-2260.
6. Fu, K. P., S. C. Lafredo, B. Foleno, U. M. Isaacson, J. F. Barrett, A. J. Tobia, and M. E. Rosenthale. 1992. In vitro and in vivo antibacterial activities of levofloxacin (l-ofloxacin), an optically active ofloxacin. Antimicrob. Agents Chemother. 36:860-866.
7. Gerding, D. N., W. H. Hall, E. A. Schierl, and R. E. Manion. 1976. Cephalosporin and aminoglycoside concentrations in peritoneal capsular fluid in rabbits. Antimicrob. Agents Chemother. 10:901-911.
8. Lettieri, J. T., M. C. Rogge, L. Kaiser, R. M. Echols, and A. H. Heller. 1992. Pharmacokinetic profiles of ciprofloxacin after single intravenous and oral doses. Antimicrob. Agents Chemother. 36:993-996.
9. Matsui, H., and T. Okuda. 1988. Penetration of cefpiramide and cefazolin into peritoneal capsular fluid in rabbits. Antimicrob. Agents Chemother. 32:33-36.
10. National Committee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A4. National Committee for Clinical Laboratory Standards, Villanova, Pa.
11. National Research Council, Institute of Laboratory Animal Resources, Commission on Life Sciences. 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington, D.C.
12. Tally, F. P. 1978. Factors affecting antimicrobial agents in an anaerobic abscess. Antimicrob. Chemother. 4:295-304.