A 63 kDa skeletal muscle protein associated with eye muscle inflammation in Graves' disease is identified as the calcium binding protein calsequestrin

Autoimmunity

Volumn 29, Issue 1, 1999, Pages 1-9

  Gunji, K ^a   Kubota, S ^a   Stolarski, C ^a   Wengrowicz, S ^b   Kennerdell, J S ^a   Wall, J R ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Calsequestrin; Eye muscle; Graves' disease; Microsequencing; Molecular cloning; Skeletal muscle; Thyroid associated ophthalmopathy

Indexed keywords

CALSEQUESTRIN; COMPLEMENTARY DNA; CYANOGEN BROMIDE; MUSCLE PROTEIN; SUCCINATE DEHYDROGENASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; EXTRAOCULAR MUSCLE; EYE INFLAMMATION; FEMALE; GRAVES DISEASE; HUMAN; MALE; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; SARCOPLASMIC RETICULUM;

EID: 0032979594     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939908995967     Document Type: Article

References (25)

1. Weetman, A.P. Thyroid-associated eye disease: pathophysiology. Lancet 1991; 338: 25-28.
2. Burch, H. and Wartofsky, L. Graves' ophthalmopathy: current concepts regarding pathogenesis and management. Endocrine Reviews 1993; 14: 747-793.
3. Bahn, R.S. and Heufelder, A.E. Orbital connective tissue. In Kahaly, G. (ed.) Endocrine Ophthalmopathy; Molecular, Immunological and Clinical Aspects, Basel, Karger. Dev. Ophthalmol. 1993; 25: 46-57.
4. Kodama, K., Sikorska, H., Bandy Dafoe, P., Bayly, R. and Wall, J.R. Demonstration of a circulating autoantibody against a soluble eye muscle antigen in Graves' ophthalmopathy. Lancet 1982; ii: 1353-1356.
5. Hiromatsu, Y., Sato, M., Tanaka, K., Shoji, S., Nonaka, K., Chinami, M. and Fukazawa, H. Significance of anti-eye muscle antibody in patients with thyroid-associated ophthalmopathy by quantitative Western blot. Autoimmunity 1993; 14: 1-8.
6. Dakovska, L., Vulkova, H., Kovatchena, R., Todorova, S., Iozanov, B., Atanassova, I., Assianova, N., Ivanova, R. and Sarafova, A. Anti-eye muscle antibodies in patients with thyroid-associated ophthalmopathy (TAO). Proc. Annual Balkan Congress of Endocrinology, Bursa, Turkey, 1995 (abstract).
7. Kendler, D.L., Rootman, J., Huber, K. and Davies, T.F. A 64kDa membrane antigen is recurrent epitope for natural autoantibodies in patients with Graves' thyroid and ophthalmic diseases. Clin. Endocrinol. 1991; 35: 539-547.
8. Salvi, M., Miller, A. and Wall, J.R. Human orbital tissue and thyroid membranes express a 64kDa protein which is recognized by autoantibodies in the serum of patient with thyroid-associated ophthalmopathy. FEBS Lett. 1988; 232: 135-139.
9. Salvi, M., Bernard, N., Miller, A., Zhang, Z.G., Gardini, E. and Wall, J.R. Prevalence of antibodies reactive with a 64kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy. Thyroid 1991; 1: 207-213.
10. Chang, T.C., Chang, T., Huang, Y.S., Hua, K.M., Su, R.J. and Kao, S C.S. Identification of autoantigen recognized by autoimmune ophthalmopathy sera with immunoblotting correlated with orbital computed tomography. Clin. Immunol. Immunopath. 1992; 65: 161-166.
11. Kubota, S., Gunji, K., Stolarski, C., Salvi, M., Hiromatsu, Y. and Wall, J.R. Sequencing of the 64kDa eye muscle protein associated with thyroid eye disease and its identification as the mitochondrial enzyme succinate dehydrogenase. Proc. 70th Annual meeting of the American Thyroid Association, Colorado Springs, 1997 (abstract).
12. Dong, Q., Ludgate, M. and Vassart, G. Cloning and sequencing of a novel 64kDa autoantigen recognized by patients with autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 1991; 72: 1375-1381.
13. Zhang, Z.G., Rodien, P., Dong, Q., Bernard, N.F., Salvi, M., Miller, A., Vassart, G.. Ludgate, M. and Wall, J.R. Autoantibodies in the serum of patients with autoimmune thyroid disorders react with a recombinant 98 amino acid fragment of a 64kDa eye muscle recombinant protein which is also expressed in the thyroid. Autoimmunity 1992; 13: 151-157.
14. Zhang, Z.G., Wall, J.R. and Bernard, N.F. Identification of antigenic epitopes of ID antigen recognized by antibodies in the serum of patients with thyroid-associated ophthalmopathy. Clin. Immunol. Immunopath. 1995; 77: 193-200.
15. Zhang, Z.G., Wall, J.R. and Bernard, N.F. Tissue distribution and quantitation of a gene expressing a 64kDa antigen associated with thyroid-associated orbitopathy. Clin. Immunol. Immunopath. 1996; 80: 236-244.
16. Committees of the American, European, Asia-Oceania, and Latin America Thyroid Associations, Classification of eye changes of Graves' disease. Thyroid 1992; 2: 235-236.
17. Laemmli, U.K. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 1970; 22: 680.
18. Sanger, F., Nickler, S. and Coulson, A. DNA sequencing with chain terminating inhibitor. Proc. Natl. Acad. Sci. (USA) 1977; 74: 5463.
19. Chomczynsk, P. Solubilization in formamide protects RNA from degradation. Nucleic Acids Research 1992; 20: 3791-3792.
20. Feinberg, A.P. and Vogelstein, B. A technique for radio-labelling DNA restriction endonuclease fragments to high specific radioactivity. Anal. Biochem. 1983; 132: 6-13.
21. Kreisel, W., Hidebrandt, H., Schiltz, E., Köhler, G., Spamer, C., Dietz, C., Mössner, W. and Heilmann, C. Immunogold electron microscopical detection of heat shock protein 60 (hsp60) in mitochondria of rat hepatocytes and myocardiocytes. Acta Histochemica 1994; 96: 51-62.
22. Fliegel, L., Ohnishi, M., Carpenter, M.R., Khanna, V.K., Reithmeier, R.A.F. and MacLennan, D.H. Amino acid sequence of rabbit fast twitch skeletal muscle calsequestrin deduced from cDNA and peptide sequencing. Proc. Natl. Acad. Sci. (USA) 1987; 84: 1167-1171.
23. Rachel, E., Milner, A., Konrad, S., Famulski, K.S. and Michalak, M. Calcium binding proteins in the sarcoplasmic/endoplasmic reticulum of muscle and nonmuscle cells. Mol. Cell Biochem. 1992; 112: 1-13.
24. Ohnishi, M. and Reithmeier, R.A.F. Fragmentation of rabbit skeletal muscle calsequestrin: spectral and ion binding properties of the carboxyl-terminal region. Biochem. 1987; 26: 7458-7465.
25. Gunji, K., Kubota, S. and Wall, J.R., Cloning and characterization of a novel eye muscle and thyroid shared autoantigen associated with the development of ophthalmopathy in patients with thyroid autoimmunity. Proc. 70th. Annual Meeting of the American Thyroid Association, Colorado Springs, October 1997, Thyroid (suppl.) (abstract).