Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum β-lactamase encoded by an Escherichia coli integron gene

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 3, 1999, Pages 573-581

  Poirel, Laurent ^a   Naas, Thierry ^b   Guibert, Michele ^b   Chaibi, El Bachir ^b   Labia, Roger ^c   Nordmann, Patrice ^a  

^a BICÊTRE HOSPITAL   (France)

^b HÔPITAL ANTOINE BÉCLÈRE   (France)

^c UMR 175 associee au CNRS et au MNHN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; AZTREONAM; BETA LACTAM ANTIBIOTIC; CEFALORIDINE; CEFALOTIN; CEFAMANDOLE; CEFEPIME; CEFOPERAZONE; CEFOTAXIME; CEFOXITIN; CEFPIROME; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; CLAVULANIC ACID; IMIPENEM; LATAMOXEF; PENICILLIN G; PIPERACILLIN; SULBACTAM; SULFANILAMIDE; TAZOBACTAM; TICARCILLIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BINDING AFFINITY; CASE REPORT; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME KINETICS; ESCHERICHIA COLI; GENE CASSETTE; GENE EXPRESSION; GENE STRUCTURE; GENE TRANSFER; GRAM NEGATIVE INFECTION; HUMAN; INFANT; INTEGRON; MOLECULAR CLONING; NONHUMAN; PLASMID; PRIORITY JOURNAL;

EID: 0032979374     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.3.573     Document Type: Article

References (54)

1. Ambler, R. P. 1980. The structure of β-lactamases. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 289:321-331.
2. Arakawa, Y., M. Ohta, N. Kido, M. Mori, H. Ito, T. Komatsu, Y. Fujii, and N. Kato. 1995. Chromosomal β-lactamase of Klebsiella oxytoca, a new class A enzyme that hydrolyzes broad spectrum β-lactam antibiotics. Antimicrob. Agents Chemother. 33:63-70.
3. IMP. Antimicrob. Agents Chemother. 39: 1612-1615.
4. Barthélémy, M., M. Guionie, and R. Labia. 1978. β-Lactamases: determination of their isoelectric points. Antimicrob. Agents Chemother. 13:695-698.
5. Barthélémy, M., J. Péduzzi, H. Bernard, C. Tancrède, and R. Labia. 1992. Close amino acid sequence relationship between the new plasmid-mediated extended spectrum β-lactamase MEN-1 and chromosomally encoded enzymes of Klebsiella oxytoca. Biochim. Biophys. Acta 1122:15-22.
6. Bauernfeind, A., I. Stemplinger, R. Jungwirth, S. Ernst, and J. M. Casellas. 1996. Sequences of β-lactamase genes encoding CTX-M-1 (MEN-1) and CTX-M and relationship of their amino acid sequences with those of β-lactamases. Antimicrob. Agents Chemother. 40:509-513.
7. PER-2, which encodes an extended-spectrum class A β-lactamase. Antimicrob. Agents Chemother. 40:616-620.
8. Boissinot, M., and R. C. Levesque. 1990. Nucleotide sequence of the PSE-4 carbenicillinase gene and correlations with the Staphylococcus aureus PC1 β-lactamase crystal structure. J. Biol. Chem. 265:1225-1230.
9. Bouthors, A.-T., N. Dagoneau-Blanchard, T. Naas, P. Nordmann, V. Jarlier, and W. Sougakoff. 1998. Role of residues 104, 164, 166, 238 and 240 in the substrate profile of PER-1 β-lactamase hydrolysing third-generation cephalosporins. Biochem. J. 330:1443-1449.
10. Bush, K., G. A. Jacoby, and A. A. Medeiros. 1995. A functional classification scheme for β-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39:1211-1233.
11. Chan, P. I. 1986. Nucleotide sequence of the Staphylococcus aureus PC1 β-lactamase gene. Nucleic Acids Res. 14:5940.
12. Collis, C. M., and R. M. Hall. 1992. Site-specific deletion and rearrangement of integron insert genes catalyzed by the integron DNA integrase. J. Bacteriol. 174:1574-1585.
13. Danel, F., L. M. C. Hall, D. Gur, H. E. Akalin, and D. M. Livermore. 1995. Transferable production of PER-1 β-lactamase in Pseudomonas aeruginosa. J. Antimicrob. Chemother. 35:281-294.
14. Hall, L. M. C., D. M. Livermore, D. Gur, M. Akova, and H. E. Akalin. 1993. OXA-11, an extended-spectrum variant of OXA-10 (PSE-2) β-lactamase from Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 37:1637-1644.
15. Hall, R. M., and C. M. Collis. 1995. Mobile gene cassettes and integrons: capture and spread of genes by site specific recombination. Mol. Microbiol. 15:593-600.
16. Heffron, F., B. J. McCarthy, H. Ohtsubo, and E. Ohtsubo. 1979. DNA sequence analysis of the transposon Tn3: three genes and three sites involved in the transposition of Tn3. Cell 18:1153-1163.
17. Hollingshead, S., and D. Vapnek. 1985. Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenyltransferase. Plasmid 13: 17-20.
18. Huletsky, A., F. Couture, and R. C. Levesque. 1990. Nucleotide sequence and phylogeny of SHV-2 β-lactamase. Antimicrob. Agents Chemother. 34:1725-1732.
19. Ishii, Y., A. Ohno, H. Taguchi, S. Imajo, M. Ishiguro, and H. Matsuzawa. 1995. Cloning and sequence of the gene encoding a cefotaxime-hydrolyzing class A beta-lactamase isolated from E. coli. Antimicrob. Agents Chemother. 39:2269-2275.
20. Joris, B., J. M. Ghuysen, G. Dive, A. Renard, O. Dideberg, P. Charlier, J. M. Frère, J. A. Kelly, J. C. Boyington, P. C. Moews, and J. R. Knox. 1988. The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family. Biochem. J. 250:313-324.
21. Joris, B., P. Ledent, O. Dideberg, E. Fonzé, J. Lamotte-Brasseur, J. A. Kelly, J. M. Ghuysen, and J. M. Frère. 1991. Comparison of the sequences of class A β-lactamases and of the secondary structure elements of penicillin-recognizing proteins. Antimicrob. Agents Chemother. 35:2294-2301.
22. Juteau, J.-M., and R. C. Levesque. 1990. Sequence analysis and evolutionary perspectives of ROB-1 β-lactamases. Antimicrob. Agents Chemother. 34: 1354-1359.
23. Labia, R., M. Guionie, M. Barthélémy, and A. Philippon. 1981. Properties of three carbenicillin hydrolysing β-lactamases (CARB) from Pseudomonas aeruginosa: identification of a new enzyme. J. Antimicrob. Chemother. 7:49-56.
24. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
25. Lenzini, M. V., H. Ishihara, J. Dusart, H. Ogawara, B. Joris, J. Van Beemen, J. M. Frère, and J. M. Ghuysen. 1988. Nucleotide sequence of the gene encoding the active serine β-lactamase from Streptomyces cacaoi. FEMS Microbiol. Lett. 49:371-376.
26. Mabilat, C., J. Lourencao-Vital, S. Goussard, and P. Courvalin. 1992. A new example of physical linkage between TnI and Tn2I: the antibiotic multiple resistance region of plasmid pCFF04 encoding extended spectrum beta-lactamase TEM-3. Mol. Gen. Genet. 235:113-121.
27. Matsumoto, Y., F. Ikeda, T. Kamimura, Y. Yokota, and Y. Mine. 1989. Novel plasmid-mediated β-lactamase from Escherichia coli that inactivates oxyimino-cephalosporins. Antimicrob. Agents Chemother. 32:1243-1246.
28. Medeiros, A. A. 1997. Evolution and dissemination of β-lactamases accelerated by generations of β-lactam antibiotics. Clin. Infect. Dis. 24(Suppl.):19-45.
29. Naas, T., and P. Nordmann. 1994. Analysis of a carbapenem-hydrolyzing class A β-lactamase from Enterobacter cloacae and its LysR type regulatory protein. Proc. Natl. Acad. Sci. USA 91:7693-7697.
30. Naas, T., L. Vandel, W. Sougakoff, D. M. Livermore, and P. Nordmann. 1994. Cloning and sequence analysis of the gene for a carbapenem-hydrolysing class A β-lactamase. Sme-1, from Serratia marcescens S6, Antimicrob. Agents Chemother. 38:1262-1270.
31. 30a. National Center of Biotechnology Information Website. 11 December 1998, revision date. [Online.] http://www.ncbi.nlm.nih.gov. [15 January 1999, last date accessed.]
32. Neugebauer, K. R., R. Sprengel, and H. Schaller. 1981. Penicillinase from Bacillus licheniformis: nucleotide sequence of the gene and implications for the biosynthesis of a secretory protein in a gram-positive bacterium. Nucleic Acids Res. 9:2577-2588.
33. Nicolas, M. H., V. Jarlier, N. Honore, A. Philippon, and S. T. Cole. 1989. Molecular characterization of the gene encoding SHV-3 β-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 33:2096-2100.
34. Nordmann, P., E. Ronco, T. Naas, C. Duport, Y. Michel-Briand, and R. Labia. 1994. Characterization of a novel extended-spectrum β-lactamase from Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 37:962-969.
35. Nordmann, P., and T. Naas. 1994. Sequence analysis of PER-1 extended-spectrum β-lactamase from Pseudomonas aeruginosa and comparison with class A β-lactamases. Antimicrob. Agents Chemother. 38:104-114.
36. Parker, A. C., and C. J. Smith. 1993. Genetic and biochemical analysis of a novel Ambler class A β-lactamase responsible for cefoxitin resistance in Bacteroides species. Antimicrob. Agents Chemother. 37:1028-1036.
37. 35a. Pedrós BioMolecular Research Tools Website. 16 June 1995, revision date. [Online.] http://www.fmi.ch/biology/research_tools.html. [12 December 1998, last date accessed.]
38. Perilli, M., N. Franceschini, B. Segatore, G. Amicosante, A. Ovatore, C. Duez, B. Joris, and J. M. Frère. 1991. Cloning and nucleotide sequencing of the gene encoding the β-lactamase from Citrobacter diversus. FEMS Microbiol. Lett. 83:79-84.
39. Philippon, L. N., T. Naas, A. T. Bouthors, V. Barakett, and P. Nordmann. 1997. OXA-18, a class D clavulanic-acid inhibited extended-spectrum β-lactamase from Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 41:2188-2195.
40. Recchia, G. D., and R. M. Hall. 1995. Gene cassettes: a new class of mobile elements. Microbiology 141:3015-3027.
41. Rogers, M. B., A. C. Parker, and C. J. Smith. 1993. Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A β-lactamases. Antimicrob. Agents Chemother. 37:2391-2400.
42. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N. Y.
43. Seoane, A., and J. M. G. Lobo. 1991. Nucleotide sequence of new class A β-lactamase from the chromosome of Yersinia enterocolitica: implications for the evolution of class A β-lactamases. Mol. Gen. Genet. 228:215-220.
44. Shaw, K. J., P. N. Rather, R. S. Hare, and G. H. Miller. 1993. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol. Rev. 57:138-163.
45. Smith, C. J., T. K. Bennett, and A. C. Parker. 1994. Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cbl4, encoding the species-specific β-lactamase. Antimicrob. Agents Chemother. 38:1711-1715.
46. Sougakoff, W., S. Goussard, and P. Courvalin. 1988. The TEM-3 β-lactamase, which hydrolyses broad-spectrum cephalosporins, is derived from the TEM-2 penicillinase by two amino-acid substitutions. FEMS Microbiol. Lett. 56:343-348.
47. Stokes, H. W., and R. M. Hall. 1989. A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: integrons. Mol. Microbiol. 3:1669-1683.
48. Stokes, H. W., D. B. O'Gorman, G. D. Recchia, M. Parsekhian, and R. M. Hall. 1997. Structure and function of 59-base element recombination sites associated with mobile gene cassettes. Mol. Microbiol. 3:1669-1683.
49. Strynadka, N. C. J., H. Adachi, S. E. Jensen, K. Johns, A. Sielecki, C. Betzel, K. Sutoh, and N. G. Amyes. 1992. Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 angstroem resolution. Nature (London) 359:700-705.
50. Sutcliffe, J. G. 1978. Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc. Natl. Acad. Sci. USA 75:3737-3741.
51. Swofford, D. L. 1989. PAUP (version 3.0): phylogenetic analysis using parsimony. Illinois Natural History Survey, Champaign, Ill.
52. Tolmasky, M. E., and J. H. Crosa. 1993. Genetic organization of antibiotic resistance genes (aac(6′)-Ib, aadA, and oxa-9) in the multiresistance transposon Tn1331. Plasmid 29:31-40.
53. Vahaboglu, H., R. Ozturk, G. Aygun, F. Coskunkan, A. Yaman, A. Kaygusuz, H. Leblebicioglu, I. Balik, K. Aydin, and M. Otkun. 1997. Widespread detection of PER-1-type extended-spectrum β-lactamase among nosocomial Acinetobacter and P. aeruginosa isolates in Turkey: a nationwide multicenter study. Antimicrob. Agents Chemother. 41:2265-2269.
54. Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-119.