A pilot study of low-dose erythromycin in bronchiectasis

European Respiratory Journal

Volumn 13, Issue 2, 1999, Pages 361-364

  Tsang, K W T ^a   Ho, P I ^a   Chan, K N ^a   Ip, M S M ^a   Lam, W K ^a   Ho, C S ^a   Yuen, K Y ^a   Ooi, G C ^a   Amitani, R ^b   Tanaka, E ^b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b Queen Mary Hospital ^*

Author keywords

Bronchiectasis; Cilia; Cytokines; Erythromycin; Sputum

Indexed keywords

ERYTHROMYCIN; PLACEBO;

ADULT; AGED; ARTICLE; BRONCHIECTASIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPUTUM; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; BRONCHIECTASIS; DOUBLE-BLIND METHOD; ERYTHROMYCIN; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; SPUTUM; VITAL CAPACITY;

EID: 0032979242     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.99.13236199     Document Type: Article

References (22)

1. Schleimer RP, Benenati SV, Friedman B, Bochner BS. Do cytokines play a role in leukocyte recruitment and activation in the lung? Am Rev Respir Dis 1991; 143: 1169-1174.
2. Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest 1989; 84: 1045-1049.
3. 4 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis. Chest 1995; 108: 116-122.
4. Lundgren JD, Shelhamer JH. Pathogenesis of airway mucus hypersecretion. J Allergy Clin Immunol 1990; 85: 399-417.
5. Amitani R. Wilson R, Rutman A, et al. Effects of human neutrophil elastase and bacterial proteinases on human respiratory epithelium. Am J Respir Cell Mol Biol 1991; 4: 26-32.
6. Marom ZM, Goswami SK. Respiratory mucus hypersecretion (bronchorrhea): a case discussion-possible mechanism(s) and treatment. J Allergy Clin Immunol 1991; 87: 1050-1055.
7. Kudoh S, Uetake T, Hagiwara K, et al. Clinical effects of low-dose, long-term erythromycin chemotherapy on diffuse panbronchiolitis. Jpn J Thorac Dis 1987; 25: 632-642.
8. Tsang KWT, Ooi C, Tanaka E, et al. Diffuse panbronchiolitis in Chinese patients. Thorax 1998; 53: 274-280.
9. McGuniness G, Naidich DP, Leitman BS, McCauley DI. Bronchiectasis: CT evaluation. Am J Radiol 1993; 160: 253-259.
10. Greenstone MA, Logan-Sinclair R, Cole PJ. An automated methods of recording ciliary beat frequency. IRCS Med Sci 1984; 12: 715-716.
11. Tsang KW, Ho PL, Lam WK, et al. Inhaled fluticasone reduces sputum inflammatory indices in severe bronchiectasis. Am J Respir Crit Care Meet 1998; 158: 723-727.
12. Ras G, Wilson R, Todd H, Taylor G, Cole PJ. Effect of bacterial products on neutrophil migration in vitro. Thorax 1990; 45: 276-280.
13. Wilmott RW, Kassab JT, Kilian PL, Benjamin WR. Douglas SD, Wood RE. Increased levels of interleukin- I in bronchoalveolar washings from children with bacterial pulmonary infections. Am Rev Respir Dis 1990; 142: 365-368.
14. Eller J, Lapa E, Silva JR, Poulter LW, Lode H, Cole PJ. Cells and cytokines in chronic bronchial infection. Ann NY Academy of Sciences 1994; 725: 331-345.
15. Rochat T. Pastore FD, Schlegal-Haueter SE. et al. Aerosolized rhDNase in cystic fibrosis: effect on leucocyte proteases in sputum. Eur Respir J 1996; 9: 2200-2206.
16. Salva PS, Doyle NA. Graham L, Eigen H. Doerschuk CM. TNFα, IL-8, soluble ICAM-1, and neutrophils in sputum of cystic fibrosis patients. Pediatr Pulmonol 1996; 21: 11-19.
17. Goswami SK, Kivity S, Marom Z. Erythromycin inhibits respiratory glycoconjugate secreteion from human airways in vitro. Am Rev Respir Dis 1990; 141: 72-78.
18. Tamaoki J, Isono K, Sakai N, KanemuraT, Konno K. Erythromysin inhibits chloride secretion across canine tracheal epithelial cells. Eur Respir J 1992; 5: 234-238.
19. Marom Z, Shelhamer JH, Kaliner M. Human pulmonary macrophage-derived mucus secretgogue. J Exp Med 1984; 159: 844-860.
20. Tsang KW, Rutman A, Kanthakumar K, et al. Haemophilus influenzae infection of human respiratory mucosa in low concentrations of antibiotics. Am Rev Respir Dis 1993; 148: 201-207.
21. Tanaka E. Kanthakumar K, Cundell DR, et al. The effects of erythromycin on Pseudomonas aeruginosa and neutrophil-mediated epithelial damage. J Antimicrob Chemother 1994; 33: 765-775.
22. Anderson R. Erythromycin and roxithromycin potentiate human neutrophil locomotion in vitro by inhibition of leukoattractant-activated superoxide generation and autooxidation. J Infect Dis 1989; 159: 966-973.