Studies on the metabolic fate of amrubicin hydrochloride(SM-5887), a novel antitumor agent(9) - In vivo chiral conversion of SM-5887 and stereoselectivity of reduction of the carbonyl group at the C-13 position

Japanese Pharmacology and Therapeutics

Volumn 27, Issue SUPPL. 1, 1999, Pages 557-568

  Nakai, Shunji ^a   Ito, Masaki ^a   Kanamaru, Hiroshi ^a   Nakatsuka, Iwao ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

Amrubicin hydrochloride(SM 5887); Antitumor agent; Carbonyl group; Chiral conversion; Reduction; Stereoselectivity

Indexed keywords

AMRUBICIN; ANTINEOPLASTIC AGENT; CARBONYL DERIVATIVE; DRUG METABOLITE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHIRALITY; CONTROLLED STUDY; DERIVATIZATION; DOG; DRUG BLOOD LEVEL; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG TISSUE LEVEL; DRUG URINE LEVEL; ENANTIOMER; HUMAN; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; LIVER CYTOSOL; NONHUMAN; RAT; STEREOCHEMISTRY; STEREOISOMERISM;

EID: 0032978954     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

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