A model of multivalent ligand-receptor equilibria which explains the effect of multivalent binding inhibitors

Molecular Immunology

Volumn 36, Issue 1, 1999, Pages 13-18

  Hubble, John ^a  

^a University of Bath   (United Kingdom)

Author keywords

Affinity; Interactions; Ligand; Multivalent

Indexed keywords

LIGAND;

ARTICLE; BINDING AFFINITY; CELL INTERACTION; DISSOCIATION; DISSOCIATION CONSTANT; LIGAND BINDING; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALS; COMPUTER SIMULATION; HUMANS; LIGANDS; MODELS, BIOLOGICAL; PROTEIN BINDING; RECEPTORS, CELL SURFACE;

EID: 0032978202     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(98)00116-3     Document Type: Article

References (13)

1. Adler, P., Woods, S.J., Lee, Y. C., Lee, R.T., Petri, W.A. Jr. Schnaar, R.L., 1995. High affinitybinding of the Entamoeba histolytica lectin to polyvalent N-acetylgalactosaminides.J. Biol. Chem. 270, 5164-5171.
2. Biessen, E.A.L., Beuting, D.M., Roelen, H.C.P.F, van de Marel, G.A., van Boom, J.H., van Berkel,T.J.C., 1995. Synthesis of cluster galactosides with high affinity for the hepatic asialoglycoproteinreceptor. J. Med. Chem. 38, 1538-1546.
3. DeFrees, S.A., Gaeta, F.C.A., Lin, Y.-C., IchiKwa, Y., Wong, C.-H., 1993. Ligand recognition byE-selectin - Analysis of conformation and activity of synthetic monomeric and bivalent sialyl lewis-xanalogs. J. Am. Chem. Soc. 115, 7549-7550.
4. Dintzis, R.J., Okajima, M., Middleton, M.H., Dintzis, H.M., 1990. Inhibition of antibody formationby receptor cross-linking: the molecular characteristics of inhibitory haptenated polymers. Eur. J.Immunol. 20, 229-232.
5. Hubble, J., Eisenthal, R., Whish, W.J.D., 1995. A model for the initial phase of cell/surfaceinteractions based on ligand binding phenomena. Biochemical Journal 311 (3), 917-919.
6. Hubble, J., Fang, M., Eisenthal, R., Whish, W., 1996. Progressive detachment of cells from surfaces:a consequence of heterogeneous ligand populations or a multi-site binding equilibrium? Journal ofTheoretical Biology 182, 169-172.
7. Lee, Y.C., 1992. Biochemistry of carbohydrate-protein interactions. FASEB J. 6, 319-3200.
8. Niederer, W., 1974. The interpretation of paradoxical radioimmunoassay standard curves Journal ofImmunological Methods 5, 77-82.
9. Parekh, R.B., Edge, C.J., 1994. Selectins-glycoprotein targets for therapeutic intervention ininflammation. Trends in Biotechnology 12, 339-345.
10. Spaltenstein, A., Whitesides, G.M., 1991. Polyacrylamides bearing pendant alpha-sialoside groupsstrongly inhibit agglutination of erythrocytes by influenza-virus. J. Am. Chem. Soc. 113, 686-687.
11. Walsh, J.A., 1986. Problems in recognition and diagnosis of amebiasis - estimation of the globalmagnitude of morbidity and mortality. Rev. Infect. Dis. 8, 228-238.
12. Ward, M.D., Dembo, M., Hammer, D.A., 1995. Kinetics of cell detachment: effect of ligand density.Annals of Biomedical Engineering 23, 322-331.
13. Yon, R.J., 1988. Co-operative cluster model for multivalent affinity interactions involving rigidmatrices. J. Chromatogr. 457, 13-23.