Inhaled nitric oxide, oxygen, and alkalosis: Dose-response interactions in a lamb model of pulmonary hypertension

Pediatric Pulmonology

Volumn 28, Issue 1, 1999, Pages 3-11

  Heidersbach, R Scott ^a   Johengen, Michael J ^a   Bekker, Janine M ^a   Fineman, Jeffrey R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alkalosis; Hyperoxia; Nitric oxide; Pulmonary circulation; Pulmonary hypertension

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; NITRIC OXIDE; OXYGEN;

ALKALOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERY BLOOD FLOW; ARTICLE; ARTIFICIAL VENTILATION; BLOOD PH; CLINICAL PROTOCOL; CONTROLLED STUDY; DOSE RESPONSE; INHALATIONAL DRUG ADMINISTRATION; LAMB; LUNG ARTERY PRESSURE; NEWBORN; NONHUMAN; OXYGEN THERAPY; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADMINISTRATION, INHALATION; ALKALOSIS; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HYDROGEN-ION CONCENTRATION; HYPERTENSION, PULMONARY; LINEAR MODELS; NITRIC OXIDE; OXYGEN; RESPIRATORY FUNCTION TESTS; SHEEP; TREATMENT OUTCOME; VASODILATION;

EID: 0032977540     PISSN: 87556863     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0496(199907)28:1<3::AID-PPUL2>3.0.CO;2-S     Document Type: Article

References (46)

1. Drummond WH, Gregory GA, Heymann MA, Phibbs RA. The independent effects of hyperventilation, tolazoline, and dopamine on infants with persistent pulmonary hypertension. J Pediatr 1981; 98:603-611.
2. Fineman JR, Wong J, Soifer SJ. Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs. Pediatr Res 1993;33:341-346.
3. 2 on pulmonary and systemic hemodynamics after surgery in children with congenital heart disease and pulmonary hypertension. J Pediatr 1988;113:474-479.
4. Rudolph AM. Fetal and neonatal pulmonary circulation. Annu Rev Physiol 1979;41:383-395.
5. Morin FC, Egan EA, Ferguson W, Lundgren CEG. Development of pulmonary vascular response to oxygen. Am J Physiol 1988; 254:542-546.
6. Morin FC. Hyperventilation, alkalosis, prostaglandins, and pulmonary circulation of the newborn. J Appl Physiol 1986;61:2088-2094.
7. Redding OJ, Gibson RL, Davis CB, Truog WE. Effects of respiratory alkalosis on thromboxane-induced pulmonary hypertension in piglets. Pediatr Res 1988;24:558-562.
8. Schreiber MD, Soifer SJ. Respiratory alkalosis attenuates thromboxane-induced pulmonary hypertension. Crit Care Med 1988;16: 1225-1228.
9. Clark JM, Lambertsen CJ. Pulmonary oxygen toxicity: a review. Pharmacol Rev 1971;23:37-133.
10. Ferrara B, Johnson DE, Chiang P, Thompson TR. Efficacy and outcome of profound hypocapneic alkalosis for the treatment of persistent pulmonary hypertension in infancy. J Pediatr 1984;105: 457-461.
11. Roissant R, Falke KJ, Lopez, F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 1993;328:399-405.
12. Roberts JD, Polaner DM, Lang P, Zapol WM. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992;340:818-819.
13. Kinsella JP, Neish SR, Shaffer E, Abman SH. Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992;340:819-820.
14. Fiscus RR. Molecular mechanisms of endothelium-mediated vasodilation. Semin Thromb Hemost [Suppl] 1988;14:12-22.
15. Rimar S, Gillis CN. Selective pulmonary vasodilation by inhaled nitric oxide is due to hemoglobin inactivation. Circulation 1993; 88:2884-2887.
16. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of Superoxide and nitric oxide. Arch Biochem Biophys 1991;288: 481-487.
17. Oda H, Kusumoto S, Kakajimia T. Nitrosyl-hemoglobin formation in the blood of animals exposed to nitric oxide. Arch Environ Health 1975;30:453-465.
18. Neonatal Inhaled Nitric Oxide Study Oroup. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med 1997;336:597-604.
19. Roberts JD, Fineman JR, Morin FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. N Engl J Med 1997;336:605-610.
20. Abman SH, Griebel JL, Parker DK, Schmidt JM, Swanton D, Kinsella JP. Acute effects of inhaled nitric oxide in children with severe hypoxemic respiratory failure. J Pediatr 1994;124:881-888.
21. Allman KG, Young JD, Stevens JE, Archer LNJ. Nitric oxide treatment for acute respiratory failure in children. Pediatr Anesth 1994;4:331-334.
22. Krafft P, Fridrich P, Fitzgerald RD, Koc D, Steltzer H. Effectiveness of nitric oxide inhalation in septic ARDS. Chest 1996;109: 486-493.
23. Allman KG, Young JD, Carapiet D, Stevens JE, Ostman Smith I, Archer LNJ. Effects of oxygen and nitric oxide in oxygen on pulmonary arterial pressure of children with congenital cardiac defects. Pediatr Cardiol 1996;17:246-250.
24. Atz AM, Wessel DL. Inhaled nitric oxide in the neonate with cardiac disease. Semin Perinatol 1997;21:441-455.
25. Zayek M, Cleveland D, Morin FC. Treatment of persistent pulmonary hypertension in the newborn lamb by inhaled nitric oxide. J Pediatr 1993;122:743-750.
26. Berger JI, Gibson RL, Redding GJ, Standaert TA, Clarke WR, Truog WE. Effect of inhaled nitric oxide during group B streptococcal sepsis in piglets. Am Rev Respir Dis 1993;147:1080-1086.
27. Dyar O, Young JD, Xiong L, Howell S, Johns E. Dose-response relationship for inhaled nitric oxide in experimental pulmonary hypertension in sheep. Br J Anaesth 1993;71:702-708.
28. Etches PC, Finer NN, Barrington KJ, Graham AJ, Chan WKY. Nitric oxide reverses acute hypoxic pulmonary hypertension in the newborn piglet. Pediatr Res 1994;35:15-19.
29. Shah NS, Nakayama DK, Jacob TD, Nishio I, Imai T, Billiar TR, Exler R, Yousem SA, Etsuro KM, Peitzman AB. Efficacy of inhaled nitric oxide in a porcine model of adult respiratory distress syndrome. Arch Surg 1994;129:158-164.
30. Barrington KJ, Finer NN, Peliowski A, etches PC, Graham AJ, Chan WKY. Inhaled nitric oxide improves oxygenation in piglets with meconium aspiration. Pediatr Pulmonol 1995;20:27-33.
31. Emil S, Kosi M, Berkeland J, Kanno S, Newth C, Atkinson J. Severity of hypoxia predicts response to nitric oxide in a porcine pulmonary hypertension model. J Pediatr Surg 1995;30:930-936.
32. Emil SGS, Berkeland JE, Atkinson JB. Nitric oxide dose response during moderate and severe hypoxia in swine. Ann Thorac Surg 1997;63:414-418.
33. Rais-Bahrami K, Rivera O, Seale WR, Short BL. Effect of nitric oxide in meconium aspiration syndrome after treatment with surfactant. Crit Care Med 1997;25:1744-1747.
34. Booke M, Bradford DW, Hinder F, Nishida K, Biondo NA, Traber LD, Traber DL. Inhaled nitric oxide selectively reduces pulmonary hypertension after ovine smoke inhalation but does not improve oxygenation. J Burn Care Rehabil 1997;18:27-33.
35. Finer NN, Etches PC, Kamstra B, Tierney AJ, Peliowski A, Ryan CA. Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: dose response. J Pediatr 1994;124:302-308.
36. Puybasset L, Rouby JJ, Mourgeon E, Stewart TE, Cluzel P, Arthaud M, Poete P, Bodin L, Korinek AM, Viars P. Inhaled nitric oxide in acute respiratory failure: dose-response curves. Intensive Care Med 1994;20:319-327.
37. Day RW, Guarin M, Lynch JM, Vernon DD, Dean JM. Inhaled nitric oxide in children with severe lung disease: results of acute and prolonged therapy with two concentrations. Crit Care Med 1996;24:215-221.
38. Demirakca S, Dotsch J, Knothe C, Magsaam J, Reiter HL, Bauer J, Kuehl PG. Inhaled nitric oxide in neonatal and pediatric acute respiratory distress syndrome: dose-response, prolonged inhalation, and weaning. Crit Care Med 1996;24:1913-1919.
39. Nakagawa TA, Moms A, Gomez RJ, Johnston SJ, Sharkey PT, Zaritsky AL. Dose response to inhaled nitric oxide in pediatric patients with pulmonary hypertension and acute respiratory distress syndrome. J Pediatr 1997;131:63-69.
40. Lonnqvist PA. Inhaled nitric oxide in newborn and paediatric patients with pulmonary hypertension and moderate to severe impaired oxygenation: effects of dose of 3-100 parts per million. Intensive Care Med 1997;23:773-779.
41. Turanlahti MI, Laitinen PO, Sarna SJ, Pesonen E. Nitric oxide, oxygen, and prostacyclin in children with pulmonary hypertension. Heart 1998;79:169-174.
42. + ion concentration changes. J Clin Invest 1966; 45:399-411.
43. Puybasset L, Stewart T, Rouby J, Cluzel P, Mourgeon E, Belin M, Arthaud M, Landault C, Viars P. Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with acute respiratory distress syndrome. Anesthesiology. 1994;80:1254-1267.
44. 2, attenuates hypoxia-induced pulmonary vasoconstriction in newborn lambs. Pediatr Res 1986;20:113-117.
45. Galantowicz ME, Price M, Stolar CJH. Differential effects of alveolar and arterial oxygen tension on pulmonary vascular tone in ECMO-perfused, isolated piglet lungs. J Pediatr Surg 1991;26: 312-316.
46. Gibson RL, Truog WE, Redding GJ. Thromboxane-associated pulmonary hypertension during three types of gram-positive bacteremia in piglets. Pediatr Res 1988;23:553-556.