The development of lewisite vapour induced lesions in the domestic, white pig

International Journal of Experimental Pathology

Volumn 80, Issue 1, 1999, Pages 59-67

  Rice, P ^a,b   Brown, R F R ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

^b Biomedical Sciences   (United Kingdom)

Author keywords

Burn; Chemical; Dichloro(2 chlorovinyl)arsine; Domestic pig; Histopathology; Lewisite; Skin lesion(s)

Indexed keywords

LEWISITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL BURN; CHEMICAL WARFARE; CONTROLLED STUDY; DNA ALKYLATION; FEMALE; HISTOPATHOLOGY; LUNG BURN; NONHUMAN; PRIORITY JOURNAL; SWINE; WOUND HEALING;

ANIMALS; ARSENIC POISONING; ARSENICALS; BURNS, CHEMICAL; EPIDERMIS; FEMALE; SKIN DISEASES; SWINE; TIME FACTORS; WOUND HEALING;

EID: 0032977261     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.1999.00099.x     Document Type: Article

References (17)

1. BROWN R.F.R. & RICE P. (1997). Histopathological changes in Yucatan minipig skin following challenge with sulphur mustard. A sequential study of the first twenty-four hours following challenge. Int. J. Exp. Pathol. 78, 9-20.
2. DAVIS J. (1944). Dermatologic aspects of vesicant war gases (dichloroethyl sulphide and dichlorovinyl arsine). J. Am. Med. Assoc. 126, 209.
3. EHRLICH P. (1909). Über den jetzigen Stand der Chemotherapie. Ber. Dt. Chem. Ges. 42, 17.
4. FLEMING S. (1991). Cell adhesion and epithelial differentiation. J. Pathol. 164 (2), 95.
5. FOX M. & SCOTT M. (1980). The genetic toxicology of nitrogen and sulphur mustard. Mutation Res. 75, 131-168.
6. GOLDMAN M. & DACRE J. (1989). Lewisite: its chemistry, toxicology and biological effects. Rev. Environ. Contamin. Toxicol. 110, 75-115.
7. KHAN M. A. (1984). Mini-pig: advantages and disadvantages as a model in toxicity testing. J. Am. Coll. Toxicol. 3, 337-342.
8. LINDSAY C.D. & RICE P. (1995). Changes in connective tissue macromolecular components of Yucatan mini-pig skin following application of sulphur mustard vapour. Hum. Exp. Toxicol. 14, 341-348.
9. MAYNARD R.L. (1996). Organic Arsenicals. In Chemical Warfare Agents: Toxicology and Treatment, eds. T.C. Marrs, R.L. Maynard & F.R. Sidell. New York: John Willey & Sons, pp 175-184.
10. MCGOWN E.L., VAN RAVENSWAY T. & DUMLAO C.R. (1987). Histologic changes in nude mouse skin and human skin xenografts following exposure to sulphhydryl reagents: arsenicals. Toxicol. Pathol. 15, 149-156.
11. MONTAGNA W. & YUN Y.S. (1964). The skin of the domestic pig. J. Invest. Dermatol. 43, 11-21.
12. PETERS R. (1953). Significance of biochemical lesions in the pyruvate oxidase system. Br. Med. Bull. 9, 116.
13. PRENTISS A.M. (1937). Chemicals in War. McGraw-Hill Book Company, New York.
14. RICE P. (1997). The surgical treatment of sulphur mustard burns. J. Defence Sci. 2 (3), 343-347.
15. SHAKESPEARE V.A. & SHAKESPEARE P.G. (1987). Growth of cultured human keratinocytes on fibrous dermal collagen: an electron scanning microscope study. Burns. 13, 343.
16. WILLEMS J.L. (1989). Clinical management of mustard gas casualties. Annales Med. Militaris (Belgicae). 3 (Suppl.), 1-61.
17. WOODLEY D.T., O'KEEFE E.J. & PRUNIERAS M. (1985). Cutaneous wound healing: a model for cell-matrix interactions. J. Am. Acad. Dermatol. 12, 420.