Inverse agonist abolishes desensitization of a constitutively active mutant of thyrotropin-releasing hormone receptor: Role of cellular calcium and protein kinase C

British Journal of Pharmacology

Volumn 126, Issue 5, 1999, Pages 1097-1106

  Grimberg, Hagit ^a   Zaltsman, Ilona ^a   Lupu Meiri, Monica ^a   Gershengorn, Marvin C ^b   Oron, Yoram ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Constitutive activity; Cytosolic calcium; Desensitization; G protein coupled receptors; Inverse agonism; Protein kinase C; Thyrotropin releasing hormone

Indexed keywords

ACETYLCHOLINE; CALCIUM ION; CHELERYTHRINE; CHLORDIAZEPOXIDE; CHLORIDE ION; COMPLEMENTARY DNA; COMPLEMENTARY RNA; EGTAZIC ACID; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; MUSCARINIC M1 RECEPTOR; MUTANT PROTEIN; N ACETYL 5 METHOXYKYNURENAMINE; OKADAIC ACID; PHORBOL 12 ACETATE 13 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTIRELIN; PROTIRELIN RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CHLORIDE CURRENT; CONTROLLED STUDY; DNA TRANSFECTION; IMMUNOBLOTTING; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; XENOPUS LAEVIS;

EID: 0032976009     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702415     Document Type: Article

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