Effect of growth hormone (GH) during puberty in GH-deficient children: Preliminary results from an ongoing randomized trial with different dose regimens

Acta Paediatrica, International Journal of Paediatrics, Supplement

Volumn 88, Issue 428, 1999, Pages 80-84

  Wikland, K Albertsson ^a   Alm, F ^b   Aronsson, S ^c   Gustafsson, J ^d   Hagenas L ^b   Hager A ^e   Ivarsson, S ^f   Kristrom B ^a,g   Marcus, C ^h   Moell C ^f   Nilsson, K O ^f   Ritzen M ^b   Tuvemo, T ^d   Westgren, U ^f   Westphal, O ^a   Aman J ⁱ  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c HALMSTAD HOSPITAL   (Sweden)

^d UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^e Linkoping Hospital   (Sweden)

^f LUND UNIVERSITY HOSPITAL   (Sweden)

^g UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^h KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

ⁱ ÖREBRO MEDICAL CENTRE HOSPITAL   (Sweden)

Author keywords

Dose; Final height; Growth hormone treatment; Puberty; Randomized treatment trial

Indexed keywords

GROWTH HORMONE;

ADOLESCENT; BODY HEIGHT; CHILD; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONAL THERAPY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PUBERTY; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADOLESCENT; BODY HEIGHT; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; MALE; PUBERTY; SWEDEN; TREATMENT OUTCOME;

EID: 0032975538     PISSN: 08035326     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (20)

1. Burns EC, Tanner JM, Preece MA, Cameron N. Final height and pubertal development in 55 children with idiopathic growth hormone deficiency, treated for between 2 and 15 years with human growth hormone. Eur J Paediatr 1981;137:155-64
2. Burns EC, Tanner JM, Preece MA, Cameron N. Growth hormone treatment in children with craniopharyngioma: final growth status. Clin Endocrinol (Oxf) 1981;14:587-95
3. Joss E, Zuppinger K, Schwarz HP, Roten H. Final height of patients with pituitary growth failure and changes in growth variables after long term hormonal therapy. Paediatr Res 1983;17:676-9
4. Rikken B, Massa GG, Wit JM. Final height in a large cohort of Dutch patients with growth hormone deficiency treated with growth hormone. Dutch Growth Hormone Working Group. Horm Res 1995;43:135-7
5. Blethen SL, Baptista J, Kuntze J, Foley T, LaFranchi S, Johanson A. Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH. The Genentech Growth Study Group. J Clin Endocrinol Metab 1997;82:418-20
6. Albertsson-Wikland K, Westphal O, Westgren U. Daily subcutaneous administration of human growth hormone in growth hormone deficient children. Acta Paediatr Scand 1986;75:89-97
7. Kastrup KW, Christiansen JS, Andersen JK, Orskov H. Increased growth rate following transfer to daily sc administration from three weekly im injections of hGH in growth hormone deficient children. Acta Endocrinol (Copenh) 1983;104:148-52
8. Hermanussen M, Geiger-Benoit K, Sippell WG. Catch-up growth following transfer from three times weekly im to daily sc administration of hGH in GH deficient patients, monitored by knemometry. Acta Endocrinol (Copenh) 1985;109:163-8
9. Albertsson-Wikland K, Rosberg S, Karlberg J, Groth T. Analysis of 24-hour growth hormone profiles in healthy boys and girls of normal stature: relation to puberty. J Clin Endocrinol Metab 1994;78:1195-201
10. Albertsson-Wikland K, Rosberg S, Libre E, Lundberg LO, Groth T. Growth hormone secretory rates in children as estimated by deconvolution analysis of 24-h plasma concentration profiles. Am J Physiol 1989;257(6 Pt 1):E 809-14
11. Karlberg P, Taranger J, Engström I, Lichtenstein H, Svennberg-Redegren I. The somatic development of children in a Swedish urban community. Acta Paediatr Scand Suppl 1976;258:7-76
12. Tanner JM, Whitehouse RM. Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty. Arch Dis Child 1976;51:170-202
13. Zachmann M, Prader A, Kind HP, Häflinger H, Budlinger H. Testicular volume during adolescence. Cross-sectional and longitudinal studies. Helv Paediatr Acta 1974;29:61-72
14. Kriström B, Karlberg J, Albertsson-Wikland K. Prediction of the growth response of short prepubertal children treated with growth hormone. Acta Paediatr 1995;84:51-67
15. Kriström B, Jansson C, Rosberg S, Albertsson-Wikland K. Growth response to growth hormone (GH) treatment relates to serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in short children with various GH secretion capacities. J Clin Endocrinol Metab 1997;82:2889-98
16. Rosenfeld RG, Albertsson-Wikland K, Cassorla F, Frasier SD, Hasegawa Y, Hintz RL, et al. Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab 1995;80:1532-40
17. Rosenfeld RG. Is growth hormone deficiency a viable diagnosis? J Clin Endocrinol Metab 1997;82:349-51
18. Blethen SL, Compton P, Lippe BM, Rosenfeld RG, August GP, Johanson A. Factors predicting the response to growth hormone (GH) therapy in children with GH deficiency. J Clin Endocrinol Metab 1993;76:574-9
19. Spagnoli A, Spadoni GL, Cianfarani S, Pasquino AM, Troiani S, Boscherini B. Prediction of the outcome of growth hormone therapy in children with idiopathic short stature. A multivariate discriminant analysis. J Pediatr 1995;126:905-9
20. Ranke MB, Guilbaud O, Lindberg A, Cole T. Prediction of the growth response in children with various growth disorders treated with growth hormone: analysis of data from the Kabi Pharmacia International Growth Study. Acta Paediatr Suppl 1993;391:82-8