Antitumor pyrido[3,2-d][1]benzazepines: Synthesis and in vitro activity of thiophene analogs

Pharmazie

Volumn 54, Issue 3, 1999, Pages 163-166

  Link, A ^c   Zaharevitz, D W ^a   Kunick, Conrad ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF HAMBURG   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 DIMETHYLAMINOETHYL) 9 METHOXY 5 NITROPYRAZOLO[3,4,5 KL]ACRIDINE; 5 CHLOROSULFAQUINOXALINE; 6 O METHYLGUANINE; ANTINEOPLASTIC AGENT; BLEOMYCIN; CHLOROZOTOCIN; DIAZIQUONE; LOSOXANTRONE; MITOXANTRONE; PENCLOMEDINE; PYRIDO[3,2 D]BENZAZEPINE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION KINETICS; DRUG SELECTIVITY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; KIDNEY CELL; STRUCTURE ACTIVITY RELATION;

EID: 0032974994     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Link, A.; Kunick, C.: J. Med. Chem. 41, 1299 (1998)
2. National Cancer Institute, unpublished results
3. Erlenmeyer, H.; Berger, E.; Leo, M.: Helv. Chim. Acta 16, 733 (1933)
4. Engel, J.: Chem. Ztg. 103, 161 (1979)
5. Patani, G. A.; LaVoie, E. J.: Chem. Rev. 96, 3147 (1996)
6. Kunick, C.; Link, A.: J. Heterocycl. Chem. 32, 803 (1995)
7. Kunick, C.: Arch. Pharm. (Weinheim) 324, 579 (1991)
8. Boyd, M. R.: Principles Practice Oncol. 3 (10), 1 (1989)
9. Sikic, B. I.: J. Natl. Cancer Ins. 83, 738 (1991)
10. Grever, M. R.; Schepartz, S. A.; Chabner, B. A.: Semin. Oncol. 19, 622 (1992)
11. Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J,: Vistica, D.; Warren, J. T.; Bokesch, H.; Kenney, S.; Boyd, M. R.: J. Natl. Cancer Inst. 82, 1107 (1990)
12. Rubinstein, L. V.; Shoemaker, R. H.; Paull, K. D.; Simon, R. M.: Tosini, S.; Skehan, P.; Scudiero, D. A.; Monks, A.; Boyd, M. R.: J. Natl. Cancer Inst. 82, 1113 (1990)
13. Monks, A.; Scudiero, D.; Skehan, P.; Shoemaker, R.; Paull, K.; Vistica, D.; Hose, C.; Langley, J.; Cronise, P.; Vaigro-Wolff, A.; Gray-Goodrich, M.; Campbell, H.; Mayo, J.; Boyd, M.: J. Natl. Cancer Inst. 83, 757 (1991)
14. Paull, K. D.; Shoemaker, R. H.; Hodes, L.; Monks, A.; Scudiero, D. A.; Rubinstein, L.; Plowman, J.; Boyd, M. R.: J. Natl. Cancer Inst. 81, 1088 (1989)
15. Paull, K. D.; Hamel, E.; Malspeis, L.; in: Foyo, W. O. (Ed.): Cancer Therapeutic Agents, Chapter 2, p. 9. American Chemical Society Books, Washington D.C. 1995
16. Weinstein, J. N.; Myers, T. G.; O'Connor, P. M.; Friend, S. H.; Fornace, A. J. Jr.; Kohn, K. W.; Fojo, T.; Bates, S. E.; Rubinstein, L. V.; Anderson, N. L.; Buolamwini, J. K.; van Osdol, W. W.; Monks, A. P.; Scudiero, D. A.; Sausville, E. A.; Zaharevitz, D. W.; Bunow, B.; Viswanadhan, V. N.; Johnson, G. S.; Wittes, R. E.; Paull, K. D.: Science 275, 343 (1997)
17. Bates, S. E.; Fojo, A. T.; Weinstein, J. N.; Myers, T. G.; Alvarez, M.; Paull, K. D.; Chabner, B. A.: J. Cancer Res. Clin. Oncol. 121, 495 (1995)
18. Leteurtre, F., Kohlhagen, G.; Paull, K. D.; Pommier, Y.: J. Natl. Cancer Inst. 86, 1239 (1994)
19. Paull, K. D.; Lin, C. M.; Malspeis, L.; Hamel, E.: Cancer Res. 52, 3892 (1992)
20. Cleaveland, E. S.; Monks, A.; Vaigro-Wolfl, A.; Zaharevitz, D. W.; Paull, K.; Ardalan, K.; Cooney, D. A.; Ford, H. Jr.: Biochem. Pharmacol. 49, 947 (1995)
21. The NCI Standard Agent Database is accessible via internet from the address http://epnws1.ncifcrf.gov:2345/dis3d/itb/stdagnt.html