Synthesis and biological activity of the metabolites of N-[2-(1- azabicyclo[3.3.0]octan-5-yl)ethyl]-2-nitroaniline Fumarate (SK-946)

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 6, 1999, Pages 880-883

  Suzuki, Tomoo ^a   Inagaki, Hideaki ^a   Hamajima, Hitoshi ^a   Uesaka, Hiroshi ^a   Hori, Kohsuke ^a   Ikami, Takao ^a  

^a SANWA KAGAKU KENKYUSHO CO LTD   (Japan)

Author keywords

1 azabicyclo 3.3.0 octane; Metabolite; Muscarinic receptor affinity; SK 946

Indexed keywords

2,8 DIMETHYL 3 METHYLENE 1 OXA 8 AZASPIRO[4.5]DECANE; DRUG METABOLITE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; N METHANESULFONYL 3 [[1 [N (2 NAPHTHOYL)VALYL]PROLYL]AMINO] 4 OXOBUTANAMIDE; N [2 (1 AZABICYCLO[3.3.0]OCTAN 5 YL)ETHYL] 2 NITROANILINE FUMARATE; N [2 (1 AZABICYCLO[3.3.0]OCTAN 5 YL)ETHYL] 4 HYDROXY 2 ANILINE; PIRENZEPINE; QUINUCLIDINYL BENZILATE; TRITIUM; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RECEPTOR AFFINITY; THIN LAYER CHROMATOGRAPHY;

EID: 0032974719     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.880     Document Type: Article

References (6)

1. a) Suzuki T., Oka M., Maeda K., Furusawa K., Mitani T., Kataoka T., Chem. Pharm. Bull., 45, 1218-1220 (1997);
2. b) Suzuki T., Oka M., Maeda K., Furusawa K., Uesaka H., Kataoka T., ibid., 47, 28-36 (1999).
3. Suzuki To., Usui T., Oka M., Suzuki Tsu., Kataoka T., Chem. Pharm. Bull., 46, 1265-1273 (1998).
4. Major basic metabolites in dog urine were prepared using a strong cation exchange (SCX) solid-phase extraction (SPE) column (Bond Elut, Analytichem International). Subsequently, the structures of the metabolites were confirmed by NMR and MS analyses (unpublished data).
5. Oka M., Baba K., Suzuki T., Matsumoto Y., Heterocycles, 45, 2317-2320 (1997).
6. Tsukamoto S., Fujii M., Yasunaga T., Matsuda K., Wanibuchi F., Hidaka A., Furuya T., Tamura T., Chem. Pharm. Bull., 43, 842-852 (1995).