Synthesis and screening of a combinatorial library of naphthalene substituted chalcones: Inhibitors of leukotriene B4

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 6, 1999, Pages 1237-1240

  Deshpande, Anil M ^a   Argade, Narshinha P ^a   Natu, Arvind A ^a   Eckman, Joseph ^b  

^a NATIONAL CHEMICAL LABORATORY   (India)

^b CytoMed Inc   (United States)

Author keywords

Antiinflammatories; Enzyme inhibitors; Leukotrienes; Naphthalene chalcones

Indexed keywords

CHALCONE; LEUKOTRIENE B4 RECEPTOR ANTAGONIST;

ASTHMA; BLOOD; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INFLAMMATION; LIBRARY; PSORIASIS; RHEUMATOID ARTHRITIS; SHORT SURVEY; SOLID PHASE EXTRACTION; ULCERATIVE COLITIS;

EID: 0032974281     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00047-4     Document Type: Article

References (15)

1. (a) Dahlen, S. E.; Hedqvist, P.; Hammarstrom, S.; Samuelsson, B. Nature 1980, 288, 484.
2. (b) Drazen, J. M.; Austen, K. F.; Lewis, R. A.; Clark, D. A.; Goto, G.; Marfat, A.; Corey, E. J. Proc. Natl. Acad. Sci. USA 1980, 77, 4354.
3. Camp, R. D. R.; Coutts, A. A.; Greaves, M. W.; Kay, A. B.; Walport, M. J. Br. J. Pharmacol. 1983, 80, 497.
4. McMillan, R. M.; Foster, S. J. Agents Actions 1988, 24, 114.
5. O'Donnell, M.; Welton, A. Thrapeutic Approaches to Inflammatory Diseases; Lewis, A. J.; Doherty, N. S.; Ackerman, N. R., Eds.; Elsevier: New York, 1989; pp.169-193.
6. Stewart, A. O.; Bhatia, P. A.; Martin, J. G.; Summers, J. B.; Rodriques, K. E.; Martin, M. B.; Holms, J. H.; Moore, J. L.; Craig, R. A.; Kolasa, T.; Ratajczyk, J. D.; Mazdiyasni, H.; Kerdesky, F. A. J.; DeNinno, S. L.; Maki, R. G.; Bouska, J. B.; Young, P. R.; Lanni, C.; Bell, R. L.; Carter, G. W.; Brooks, C. D. W. J. Med. Chem. 1997, 40, 1955.
7. Bruneau, P.; Delvare, C.; Edwards, M. P.; McMillan, R. M. J. Med. Chem. 1991, 34, 1028.
8. (a) Herencia, F.; Ferrandiz, M. L.; Ubeda, A.; Dominguez, J. N.; Charris, J. E.; Lobo, G. M.; Alcaraz, M. J. Bioorg. Med. Chem. Lett. 1998, 8, 1169.
9. (b) Zwaagstra, M. E.; Timmerman, H.; Tamura, M.; Thoma, T.; Wada, Y.; Onogi, K.; Zhang, M. J. Med. Chem. 1997, 40, 1075.
10. (c) Sogawa, S.; Nihro, Y.; Ueda, H.; Miki, T.; Matsumoto, H.; Satoh, T. Biol. Pharm. Bull. 1994, 17, 251.
11. (d) Sogawa, S.; Nihro, Y.; Ueda, H.; Izumi, A.; Miki, T.; Matsumoto, H.; Satoh, T. J. Med. Chem. 1993, 36, 3904.
12. Summers, J. B.; Mazdiyasni, H.; Holms, J. H.; Ratajczyk, J. D.; Dyer, R. D.; Carter, G. W. J. Med. Chem. 1987, 30, 575.
13. Olah, G. A.; Friedel Crafts and Related Reactions Vol III; Gore, P. H., Eds.; Interscience: New York, 1963; chapter 1, pp. 1-75.
14. Kohler, E. P.; Chadwell, H. M. Org. Synth. 1922, 2, 1.
15. Brooks, D. W.; Summers, J. B.; Stewart, A. O.; Bell, R. L.; Bosuka, J.; Lanni, C.; Rubin, P.; Carter, G. W. Novel inhibitors of leukotriene biosynthesis. In Perspective in Medicinal Chemistry; Testa, B.; Kyburz, E.; Fuhrer, W.; Giger, R., Eds.; Verlag: Basel, 1993; Chapter 9, pp. 119-134.