Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats

Physiology and Behavior

Volumn 66, Issue 5, 1999, Pages 823-831

  Pletnikov, Mikhail V ^a,b   Rubin, Steven A ^a   Schwartz, Gary J ^b   Moran, Timothy H ^b   Sobotka, Thomas J ^c   Carbone, Kathryn M ^a,b  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Anxiety; Borna; Cerebellum; Fear; Hippocampus; Rat

Indexed keywords

AFFECTIVE NEUROSIS; ANIMAL MODEL; ANXIETY; ARTICLE; AUDITORY STIMULATION; BORNA DISEASE VIRUS; BRAIN DEVELOPMENT; BRAIN INFECTION; BRAIN INJURY; CEREBELLUM; CONTROLLED STUDY; DEFECATION; DENTATE GYRUS; HYPERACTIVITY; IMMUNOHISTOCHEMISTRY; NEWBORN; NEWBORN INFECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SHOCK;

EID: 0032974007     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(99)00021-9     Document Type: Article

References (51)

1. Altman J. Morphological and behavioral markers of environmentally induced retardation of brain development. An animal model Environ. Health Perspect. 74:1987;153-168.
2. Antelman S.M., Brown T.S. Hippocampal lesions and shuttlebox avoidance behavior. A fear hypothesis Physiol. Behav. 9:1972;15-20.
3. Barnett S.A., Cowan P.E. Activity, exploration, curiosity and fear. An ethological study Interdiscipl. Sci. Rev. 1:1976;43-62.
4. Bautista J.R., Rubin S.A., Moran T.H., Schwartz G.J., Carbone K.M. Early and persistent abnormalities in rats with neonatally acquired Borna disease virus infection. Brain Res. Bull. 34:1994;31-40.
5. Bautista J.R., Rubin S.A., Moran T.H., Schwartz G.J., Carbone K.M. Developmental injury to the cerebellum following perinatal Borna disease virus infection. Dev. Brain Res. 90:1995;45-53.
6. Bernston G.G., Schumacher K.M. Effects of cerebellar lesions on activity, social interactions, and other motivated behaviors in the rat. J. Comp. Physiol. Psychol. 94:1980;706-717.
7. Blanchard R.J., Blanchard D.C., Fial R.A. Hippocampal lesions in rats and their effect on activity, avoidance and aggression. J.Comp. Physiol. Psychol. 71:1970;92-102.
8. Blanchard R.J., Blanchard D.C. Defensive reactions in the albino rat. Learn. Motiv. 2:1971;351-362.
9. Blanchard R.J., Blanchard D.C. Effects of hippocampal lesions on the rat's reaction to a cat. J. Comp. Physiol. Psychol. 78:1972;77-82.
10. Borszcz G.S., Cranney J., Leaton R.N. Influence of long-term sensitization on long-term habituation of the acoustic startle response in rats. Central gray lesions, preexposure, and extinction J. Exp. Psychol. Anim. Behav. Process. 15:1989;54-64.
11. Caeser M., Ostwald J., Pilz P.K.D. Startle responses measured in muscles innervated by facial and trigeminal nerves show common modulation. Behav. Neurosci. 103:1989;1075-1081.
12. Carbone K.M., Trapp B.D., Griffin J.W., Duchala C.S., Narayan O. Astrocytes and Schwann cells are virus-host cells in the nervous systems of rats with borna disease. J. Neuropathol. Exp. Neurol. 48:1989;631-644.
13. Carbone K.M., Park S.W., Rubin S.A., Waltrip R.W. II, Vogelsang G.B. Borna disease. Association with a maturation defect in the cellular immune response J. Virol. 65:1991;6154-6164.
14. Davis M. The mammalian startle response. Eaton J.M. Neural mechanisms of the startle behavior. 1984;287-361 Plenum, New York.
15. Davis M. Sensitization of the acoustic startle reflex by footshock. Behav. Neurosci. 103:1989;495-503.
16. Dennenberg V.H. Open-field behavior in the rat. What does it mean? Ann. NY Acad. Sci. 159:1969;852-859.
17. Dittrich W., Bode L., Kao M., Schneider K. Learning deficiencies in Borna disease virus-infected but clinically healthy rats. Biol. Psychiatry. 26:1989;818-828.
18. Douglas R.J. The hippocampus and behavior. Psychol. Bull. 67:1967;416-442.
19. Fanselow M.S. Neural organization of the defensive behavior system responsible for fear. Psychonom. Bull. Rev. 1:1994;429-438.
20. Fendt M., Koch M., Schnitzler H.-U. Lesions of the central gray block the sensitization of the acoustic startle response in rats. Brain Res. 661:1994;163-173.
21. Ferguson S.A., Racey F.D., Paule M.G., Holson R. Behavioral effects of methylazoxymethanol-induced microencephaly. Behav. Neurosci. 107:1993;1067-1076.
22. Ferguson S.A. Neuroanatomical and functional alterations resulting from early postnatal cerebellar insults in rodents. Pharmacol. Biochem. Behav. 55:1996;663-671.
23. Gonzalez-Dunia D., Sauder Ch., De la Torre J.C. Borna disease virus and the brain. Brain Res. Bull. 44:1997;647-664.
24. Good M., Honey R.C. Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning. Behav. Neurosci. 111:1997;487-493.
25. Gray J. The psychology of fear and stress. Problems in the behavioural sciences. 1987;Cambridge UP, New York.
26. Hard E., Carlsson S.G., Jern S., Larsson K., Lindh A.-S., Svensson L. Behavioral reactivity in spontaneously hypertensive rats. Physiol. Behav. 35:1985;487-492.
27. Kalynchuk L.E., Pinel J.P.J., Treit D., Barnes S.J., McEachery J.C., Kippin T.E. Persistence of the interictal emotionality produced by long-term amygdala kindling in rats. Neuroscience. 85:1998;1311-1319.
28. Kim J.J., Thompson R.F. Cerebellar circuits and synaptic mechanisms involved in classical eyeblink conditioning. Trends Neurosci. 20:1997;177-181.
29. Leaton R.N., Cassella J., Whitehorn D. Locomotor activity, auditory startle and shock thresholds in spontaneously hypertensive rats. Physiol. Behav. 31:1983;103-109.
30. Levitsky D.A., Strupp B.J. Malnutrition and the brain. Changing concepts, changing concerns J. Nutr. 125:1995;2212S-2220S.
31. Ley R. Open-field behavior, emotionality during fear conditioning, and fear-motivated instrumental performance. Bull. Psychonom. Soc. 6:1975;598-600.
32. Lister R.G. Ethologically-based animal models of anxiety disorders. Pharmacol. Ther. 46:1990;321-340.
33. McNish K.A., Gewirtz J.C., Davis M. Evidence of contextual fear after lesion of the hippocampus. A disruption of freezing but not fear-potentiated startle J. Neurosci. 23:1997;9353-9360.
34. O'Keef J., Nadel L. The hippocampus as a cognitive map. 1978;Oxford University Press, Oxford.
35. Pankseep J. The psychoneurology of fear. Evolutionary perspective and the role of animal models in understanding human anxiety Burrows G.D., Roth M., Noyes R. Jr. The neurobiology of anxiety. Vol. 3, Handbook of anxiety. 1990;3-58 Elsevier, Amsterdam.
36. Pellegrino L.J., Altan J. Effects of differential interference with postnatal cerebellar neurogenesis on motor performance, activity level, and maze learning of rats. A developmental study J. Comp. Physiol. Psychol. 93:1979;1-33.
37. Ramos A., Mormede P. Stress and emotionality. A multidimensional and genetic approach Neurosci. Biobehav. Rev. 22:1998;33-57.
38. Rogers L.J., Sink H.S., Hambley J.W. Exploration, fear and maze learning in spontaneously hypertensive and normotensive rats. Behav. Neural Biol. 49:1988;222-233.
39. Rosen J.B., Schulkin J. From normal fear to pathological anxiety. Psychol. Rev. 105:1998;325-350.
40. Sanberg P.R., Moran T.H., Coyle J. Microencephaly. Cortical hypoplasia induced by methylazoxymethanol Coyle J. Animal model of dementia. 1987;253-278 Alan R. Liss, Inc, New York.
41. Saurez S.D., Gallup G.G. Jr. An ethological analysis of open-field behavior in rats and mice. Learn. Motiv. 12:1981;342-363.
42. Supple W.F. Jr., Leaton R.N., Fanselow M.S. Effects of cerebellar vermal lesions on species-specific fear responses, neophobia, and taste-aversion learning in rats. Physiol. Behav. 39:1987;579-586.
43. Supple W.F. Jr., Cranney J., Leaton R.N. Effects of lesions of the cerebellar vermis on VMH lesion-induced hyperdefensiveness, spontaneous mouse killing, and freezing in rats. Physiol. Behav. 42:1988;145-153.
44. Svensson L., Harthon Ch., Linder B. Evidence for a dissociation between cardiovascular and behavioral reactivity in the spontaneously hypertensive rat. Physiol. Behav. 49:1991;661-665.
45. Trullas R., Skolnick P. Difference in fear motivated behaviors among inbred mouse strains. Psychopharmacology (Berlin). 111:1993;323-331.
46. Vanderwolf C.H., Kelly M.E., Kraemer P., Streather A. Are emotion and motivation localized in the limbic system and nucleus accumbens? Behav. Brain Res. 27:1988;45-58.
47. Walsh T.J., Schulz D.W., Tilson H.A., Schmechel D. Colchicine-induced granule cell loss in rat hippocampus. Selective behavioral and histological alterations Brain Res. 398:1986;23-36.
48. Waltrip R.W. II, Buchanan R.W., Summerfelt A., Breier A., Carpenter W.T., Bryant N., Rubin S.A., Carbone K.M. Borna disease virus and schizophrenia. Psychol. Res. 56:1995;33-44.
49. Weker J.R., Ison J.R. Effects of motor activity on the elicitation and modification of the startle reflex in rats. Anim. Learn. Behav. 14:1986;287-292.
50. Welker L.I. "Free" versus "forced" exploration of a novel situation by rats. Psychol. Rep. 3:1957;95-108.
51. Yolken R.H., Torrey E.F. Viruses, schizophrenia and bipolar disorders. Clin. Microbiol. Rev. 8:1995;131-145.