Acetone catabolism by cytochrome P450 2E1: Studies with CYP2E1-null mice

Biochemical Pharmacology

Volumn 58, Issue 3, 1999, Pages 461-463

  Bondoc, Flordeliza Y ^a   Bao, Ziping ^a,b   Hu, Wen Yu ^a   Gonzalez, Frank J ^a   Wang, Yongyu ^a,b   Yang, Chung S ^a,b   Hong, Jun Yan ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

2E1 knockout mice; Acetone metabolism; Cytochrome P450 2E1; Fasting

Indexed keywords

ACETONE; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE DEMETHYLASE; METHYLGLYOXAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CATABOLISM; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ACETONE; ANIMALS; CYTOCHROME P-450 CYP2E1; FEMALE; MALE; MICE; MICE, INBRED C57BL;

EID: 0032973998     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00111-2     Document Type: Article

References (19)

1. Guengerich FP, Kim D-H and Iwasaki M, Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 4: 168-179, 1991.
2. Koop DR, Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J 6: 724-730, 1992.
3. Wang M-H, Wade D, Chen L, White S and Yang CS, Probing the active sites of rat and human cytochrome P450 2E1 with alcohols and carboxylic acids. Arch Biochem Biophys 317: 299-304, 1995.
4. Yang CS, Yoo JSH, Ishizaki H and Hong J-Y, Cytochrome P450IIE1: Roles in nitrosamine metabolism and mechanism of regulation. Drug Metab Rev 22: 147-159, 1990.
5. Borek E and Rittenberg D, The metabolism of acetone by surviving rat liver. J Biol Chem 179: 843-845, 1949.
6. Price TD and Rittenberg D, The metabolism of acetone. I. Gross aspects of catabolism and excretion. J Biol Chem 185: 449-459, 1950.
7. Casazza JP, Felver ME and Veech RL, The metabolism of acetone in rats. J Biol Chem 259: 231-236, 1984.
8. Casazza JP and Fu JL, Measurement of acetol in serum. Anal Biochem 148: 344-348, 1985.
9. Koop DR and Casazza JP, Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes. J Biol Chem 260: 13607-13612, 1985.
10. Stowell A, Johnsen J, Ripel A and Morland J, Disulfiram-induced acetonaemia. Lancet 1: 882-883, 1983.
11. DeMaster EG and Nagasawa HT, Disulfiram-induced acetonaemia in the rat and man. Res Commun Chem Pathol Pharmacol 18: 361-364, 1977.
12. Chen L, Lee MJ, Hong J-Y, Huang W-Q, Wang EJ and Yang CS, Relationship between cytochrome P450 2E1 and acetone catabolism in rats as studied with diallyl sulfide as an inhibitor. Biochem Pharmacol 48: 2199-2205, 1994.
13. Lee SS, Buters JT, Pineau T, Fernandez-Salguero P and Gonzales FJ, Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 271: 12063-12067, 1996.
14. Hong J-Y, Wang Y-Y, Bondoc FY, Yang CS, Gonzales FJ, Pan Z, Cokonis C and Bao ZP, Metabolism of methyl tert-butyl ether and other gasoline ethers in mouse liver microsomes lacking cytochrome P450 2E1. Toxicol Lett 105: 83-88, 1999.
15. Song BJ, Gelboin HV, Park SS, Yang CS and Gonzales FJ, Complementary DNA sequences of ethanol-inducible rat and human cytochrome P-450s: Transcriptional and post-transcriptional regulation of the rat enzyme. J Biol Chem 261: 16689-16697, 1986.
16. Stryer L, Biochemistry, pp, 478 -480. W. H. Freeman, New York, 1988.
17. Owen OE, Trapp VE, Skutches L, Mozzoli MA, Hoeldtke RD, Boden G and Reichard GA Jr. Acetone metabolism during diabetic ketoacidosis. Diabetes 31: 242-248, 1982.
18. j) by fasting. Biochem Biophys Res Commun 142: 1077-1083, 1987.
19. j) in chemically induced and spontaneously diabetic rats. Arch Biochem Biophys 263: 29-35, 1988.