Influence of ionic strength on drug adsorption onto and release from a poly(acrylic acid) grafted poly(vinylidene fluoride) membrane

International Journal of Pharmaceutics

Volumn 178, Issue 1, 1999, Pages 67-75

  Åkerman, Satu ^a   Svarfvar, Bror ^b   Kontturi, Kyösti ^c   Näsman, Jan ^b   Urtti, Arto ^a   Paronen, Petteri ^a   Järvinen, Kristiina ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c AALTO UNIVERSITY   (Finland)

Author keywords

Drug flux; Drug release; Ionic strength; Polyacrylic acid; Polymer membrane; Propranolol HCl

Indexed keywords

DEXTRAN; MANNITOL; POLYACRYLIC ACID; POLYMER; POLYVINYLIDENE FLUORIDE; PROPRANOLOL;

ARTICLE; CATION EXCHANGE; DRUG ADSORPTION; DRUG RELEASE; IONIC STRENGTH; MEMBRANE; PRIORITY JOURNAL;

ACRYLATES; ADSORPTION; DELAYED-ACTION PREPARATIONS; MEMBRANES, ARTIFICIAL; OSMOLAR CONCENTRATION; POLYMERS; PROPRANOLOL; VINYL COMPOUNDS;

EID: 0032972858     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00362-7     Document Type: Article

References (15)

1. Åkerman S., Viinikka P., Svarfvar B., Järviven K., Kontturi K., Näsman J., Urtti A., Paronen P. Transport of drugs across porous ion exchange membranes. J. Control. Release. 50:1998;153-166.
2. Bodmeier R., Guo X., Sarabia R.E., Skultety F. The influence of buffer species and strength on diltiazem HCl release from beads coated with the aqueous cationic polymer dispensions, Eugradit RS, RL 30D. Pharm. Res. 13:1996;52-56.
3. Chang C.-M., Bodmeier R. Effect of dissolution media and additives on the drug release from cubic phase delivery systems. J. Control. Release. 46:1997;215-222.
4. Charman W.N., Christy D.P., Geunin E.P., Monkhouse D.C. Interactions between calcium, a model divalent cation, and a range of poly(acrylic acid) resins as a function of solution pH. Drug Dev. Ind. Pharm. 17:1991;271-280.
5. Dittgen M., Durrani M., Lehmann K. Acrylic polymers. A review of pharmaceutical applications. S.T.P. Pharma. Sci. 7:1997;403-437.
6. Ghimici L., Dragan S., Popescu F. Interaction of low-molecular weight salts with cationic polyelectrolytes. J. Polym. Sci. Part B: Polym. Phys. 35:1997;2571-2581.
7. Hautojärvi J., Kontturi K., Näsman J., Svarfvar B., Viinikka P., Vuoristo M. Characterization of graft modified porous polymer membranes. Ind. Eng. Chem. Res. 35:1996;450-457.
8. Iwata H., Amemiya H., Hata T., Matsuda T., Takano H., Akutsu T. Development of novel semipermeable membranes for self-regulated insulin delivery systems. Proc. Intern. Symp. Control. Rel. Bioact. Mater. 15:1988;170-171.
9. Ito Y., Casolaro M., Kono K., Imanishi Y. An insulin-releasing system that is responsive to glucose. J. Control. Rel. 10:1989;195-203.
10. Jenquin M.R., Liebowittz S.M., Sarabia R.E., McGinity J.W. Physical and chemical factors influencing the release of drugs from acrylic resin films. J. Pharm. Sci. 79:1990;811-816.
11. Jenquin M.R., McGinity J.W. Characterization of acrylic resin matrix films and mechanism of drug polymer interactions. Int. J. Pharm. 10:1994;23-34.
12. Järvinen K., Åkerman S., Svarfvar B., Tarvainen T., Viinikka P., Paronen P. Drug release from pH and ionic strength responsive poly(acrylic acid) grafted poly(vinylidene fluoride) membrane bags in vitro. Pharm. Res. 15:1998;802-805.
13. Knop K. Influence of buffer solution composition on drug release from pellets coated with neutral and quaternary acrylic polymers and on swelling of free polymer films. Eur. J. Pharm. Sci. 4:1996;293-300.
14. Kriwet B., Kissel T. Interactions between bioadhesive poly(acrylic acid) and calcium ions. Int. J. Pharm. 127:1996;135-145.
15. Okada S., Nakahara H., Isaka H. Adsorption of drugs on microcrystalline cellulose suspended in aqueous solutions. Chem. Pharm. Bull. 35(2):1987;761-768.