Cyclic ADP-ribose-mediated insulin secretion and Reg, regenerating gene

Journal of Molecular Medicine

Volumn 77, Issue 1, 1999, Pages 74-78

  Okamoto, Hiroshi ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CD38; Cyclic ADP ribose; Insulin secretion; Reg; The OKAMOTO model

Indexed keywords

ADENOSINE TRIPHOSPHATE; CD38 ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONFERENCE PAPER; DIABETES MELLITUS; ENDOPLASMIC RETICULUM; INSULIN RELEASE; PANCREAS ISLET BETA CELL; SECOND MESSENGER;

EID: 0032972649     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050305     Document Type: Conference Paper

References (49)

1. 1. Yamamoto H, Okamoto H (1980) Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun 95: 474-481
2. 2. Okamoto H (1981) Regulation of proinsulin synthesis in pancreatic islets and a new aspect to insulin-dependent diabetes. Mol Cell Biochem 37: 43-61
3. 3. Yamamoto H, Uchigata Y, Okamoto H (1981) Streptozotocin and alloxan induce DNA strand breaks and poly (ADP-ribose) synthetase in pancreatic islets. Nature 294: 284-286
4. 4. Yamamoto H, Uchigata Y, Okamoto H (1981) DNA strand breaks in pancreatic islets by in vivo administration of alloxan or Streptozotocin. Biochem Biophys Res Commun 103: 1014-1020
5. 5. Uchigata Y, Yamamoto H, Kawamura A, Okamoto H (1982) Protection by superoxide dismutase, catalase, and poly (ADP-ribose) synthetase inhibitors against alloxan-and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem 257: 6084-6088
6. 6. Yamamoto H, Okamoto H (1982) Poly (ADP-ribose) synthetase inhibitors enhance streptozotocin-induced killing of insulinoma cells by inhibiting the repair of DNA strand breaks. FEBS Lett 145:298-302
7. 7. Uchigata Y, Yamamoto H, Nagai H, Okamoto H (1983) Effect of poly (ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis. Diabetes 32: 316-318
8. 8. Okamoto H (1985) Molecular basis of experimental diabetes: degeneration, oncogenesis, and regeneration of pancreatic B-cells of islets of Langerhans. BioEssays 2: 15-21
9. 9. Okamoto H (1990) The molecular basis of experimental diabetes. In: Okamoto H (ed) Molecular biology of the islets of Langerhans. Cambridge University Press, Cambridge, pp 209-231
10. 10. Yonemura Y, Takashima T, Miwa K, Miyazaki I, Yamamoto H, Okamoto H (1984) Amelioration of diabetes mellitus in partially depancreatized rats by poly (ADP-ribose) synthetase inhibitors -evidence of islet B-cell regeneration. Diabetes 33: 401-404
11. 11. Yonemura Y, Takashima T, Matsuda Y, Miwa K, Sugiyama K, Miyazaki I, Yamamoto H, Okamoto H (1988) Induction of islet B-cell regeneration in partially pancreatectomized rats by poly (ADP-ribose) synthetase inhibitors. Int J Pancreatol 3: 73-72
12. 12. Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, Okamoto H (1988) A novel gene activated in regenerating islets. J Biol Chem 263: 2111-2114
13. 13. Terazono K, Watanabe T, Yonemura Y (1990) A novel gene, reg, expressed in regenerating islets. In: Okamoto H (ed) Molecular biology of the islets of Langerhans. Cambridge University Press, Cambridge, pp 301-313
14. 14. Okamoto H (1996) The OKAMOTO model for B-cell damage: recent advances. In: Shafrir E (ed) Lessons from animal diabetes VI. Birkhauser, Boston, pp 97-111
15. 15. Lee HC, Aarhus R, Levitt D (1994) The crystal structure of cyclic ADP-ribose. Nature Struct Biol 1: 143-144
16. 16. Takasawa S, Nata K, Yonekura H, Okamoto H (1993) Cyclic ADP-ribose in insulin secretion from pancreatic β-cells. Science 259:370-373
17. + metabolite, in stimulus-secretion coupling in pancreatic B-cells. In: Flatt P, Lenzen S (eds) Frontiers of insulin secretion and pancreatic B-cell research. Smith-Gordon, London, pp 123-128
18. 18. Hedeskov CJ (1980) Mechanism of glucose-induced insulin secretion. Physiol Rev 60: 442-509
19. 19. Ashcroft FM, Ashcroft SJH (1992) Mechanism of insulin secretion. In: Ashcroft FM, Ashcroft SJH (eds) Insulin - molecular biology to pathology. Oxford University Press, Oxford, pp 97-150
20. 20. Okamoto H, Takasawa S, Tohgo A (1995) New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose. Biochimie 77: 356-363
21. 21. Okamoto H, Takasawa S, Tohgo A, Nata K, Kato I, Noguchi N (1997) Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38: inhibition of hydrolysis by ATP and the physiological significance. Meth Enzymol 280: 306-318
22. 22. Takasawa S, Tohgo A, Noguchi N, Koguma T, Nata K, Sugimoto T, Yonekura H, Okamoto H (1993) Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP. J Biol Chem 268: 26052-26054
23. 23. Kato I, Takasawa S, Akabane A, Tanaka O, Abe H, Takamura T, Suzuki Y, Nata K, Yonekura H, Yoshimoto T, Okamoto H (1995) Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic β cells: enhanced insulin secretion in CD38-expressing transgenic mice. J Biol Chem 270: 30045-30050
24. 24. Tohgo A, Munakata H, Takasawa S, Nata K, Akiyama T, Hayashi N, Okamoto H (1997) Lysine 128 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase. J Biol Chem 272: 3879-3882
25. 2+ mobilization. J Biol Chem 270: 30257-30259
26. 2+ from islet microsomes. J Biol Chem 272: 3133-3136
27. 27. Rojas E, Carroll PB, Ricordi C, Boschero AC, Stojilkovic SS, Atwater I (1994) Control of cytoplasmic free calcium in cultured human pancreatic β-cells occurs by external calcium-dependent and independent mechanisms. Endocrinology 134: 1771-1781
28. 2+, cAMP, and phospholipid-derived messenger in coupling mechanism of insulin secretion. Physiol Rev 67: 1185-1248
29. + into a calcium-mobilizing metabolite. Cell Regul 2: 203-209
30. 30. Glick DL, Hellmich MR, Beushausen S, Tempst P, Bayley H, Strumwassert F (1991) Primary structure of a molluscan egg-specific NADase, a second-messenger enzyme. Cell Regul 2: 211-218
31. 31. Nata K, Sugimoto T, Tohgo A, Takamura T, Noguchi N, Matsuoka A, Numakunai T, Shikama K, Yonekura H, Takasawa S, Okamoto H (1995) The structure of the Aplysia kurodai gene encoding ADP-ribosyl cyclase, a second-messenger enzyme. Gene 158: 213-218
32. 32. Tohgo A, Takasawa S, Noguchi N, Koguma T, Nata K, Sugimoto T, Furuya Y, Yonekura H, Okamoto H (1994) Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38. J Biol Chem 269: 28555-28557
33. 33. Koguma T, Takasawa S, Tohgo A, Karasawa T, Furuya Y, Yonekura H, Okamoto H (1994) Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (homologue to human CD38) from islets of Langerhans. Biochim Biophys Acta 1223: 160-162
34. 34. Furuya Y, Takasawa S, Yonekura H, Tanaka T, Takahara J, Okamoto H (1995) Cloning of a cDNA encoding rat bone marrow stromal cell antigen 1 (BST-1) from the islets of Langerhans. Gene 165: 329-330
35. 35. Islam S, Larsson O, Berggren P-O, Takasawa S, Nata K, Yonekura H, Okamoto H, Galione A (1993) Cyclic ADP-ribose in β cells. Science 262: 584-586
36. 36. Praz GA, Halban PA, Wollheim CB, Blondel B, Strauss AJ, Renold AE (1983) Regulation of immunoreactive-insulin release from a rat cell line (RINm5F). Biochem J 210: 345-352
37. 37. Ashcroft FM, Harrison DE, Ashcroft SJH (1984) Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells. Nature 312: 446-448
38. 38. Nakagawara K, Mori M, Takasawa S, Nata K, Takamura T, Berlova A, Tohgo A, Karasawa T, Yonekura H, Takeuchi T, Okamoto H (1995) Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15. Cytogenet Cell Genet 69: 38-39
39. 39. Watanabe T, Yonemura Y, Yonekura H, Suzuki Y, Miyashita H, Sugiyama K, Moriizumi S, Unno M, Tanaka O, Kondo H, Bone AJ, Takasawa S, Okamoto H (1994) Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein. Proc Natl Acad Sci USA 91: 3589-3592
40. 40. Unno M, Yonekura H, Nakagawara K, Watanabe T, Miyashita H, Moriizumi S, Okamoto H, Itoh T, Teraoka H (1993) Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II: a novel type of reg gene, Reg II, exists in the mouse genome. J Biol Chem 268: 15974-15982
41. 41. Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, Yonekura H, Okamoto H (1994) Isolation, structural determination and expression of a novel reg gene, human reg Iβ. Biochim Biophys Acta 1217: 199-202
42. 42. Suzuki Y, Watanabe T, Unno M, Moriizumi S, Miyashita H, Yonekura H, Okamoto H (1994) Structure and expression of a novel rat reg III gene. Gene 144: 315-316
43. 43. Yonekura H, Unno M, Watanabe T, Moriizumi S, Suzuki Y, Miyashita H, Yonemura Y, Sugiyama K, Okamoto H (1994) Structure and expression of reg gene family. In: Flatt P, Lenzen S (eds) Frontiers of insulin secretion and pancreatic B-cell research. Smith-Gordon, London, pp 581-588
44. 44. Narushima Y, Unno M, Nakagawara K, Mori M, Miyashita H, Suzuki Y, Noguchi N, Takasawa S, Kumagai T, Yonekura H, Okamoto H (1997) Structure, chromosomal localization and expression of mouse genes encoding type III Reg, Reg IIIα, Reg IIIβ, Reg IIIγ. Gene 185: 159-168
45. 45. Miyashita H, Nakagawara K, Mori M, Narushima Y, Noguchi N, Moriizumi S, Takasawa S, Yonekura H, Takeuchi T, Okamoto H (1995) Human REG family genes are tandemly ordered in a 95-kilobase region of chromosome 2p12. FEBS Lett 377: 429-433
46. 46. Okamoto H, Takasawa S, Kato I, Tohgo A, Noguchi N, Nata K, Yonekura H (1995) The role of cyclic ADP-ribose in stimulus-secretion coupling in pancreatic β-cells. In: Baba S, Kaneko T (eds) Diabetes 1994. Elsevier, Amsterdam, pp 244-246
47. 47. Gross DJ, Weiss L, Reibstein I, van den Brand J, Okamoto H, Clark A, Slavin S (1998) Amelioration of diabetes in nonobese diabetic mice with advanced disease by Linomide-induced immunoregulation combined with Reg protein treatment. Endocrinology 139:2369-2374
48. 2+ mobilization in normal and diabetic β-cells. J Biol Chem 273:2497-2500
49. 49. Okamoto H, Takasawa S, Nata K (1997) The CD38-cyclic ADP-ribose signaling system in insulin secretion: molecular basis and clinical implications. Diabetologia 40:1485-1491