UV-B-induced photooxidation of vitamin E in mouse skin

Chemical Research in Toxicology

Volumn 12, Issue 2, 1999, Pages 187-191

  Kramer Stickland, Kimberly ^a   Krol, Ed S ^a   Liebler, Daniel C ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG OXIDATION; MOUSE; NONHUMAN; PHOTOOXIDATION; SKIN CARCINOGENESIS; SKIN TOXICITY; TOPICAL DRUG ADMINISTRATION; TOXICOKINETICS; ULTRAVIOLET B RADIATION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; LIPID PEROXIDATION; MICE; MICE, INBRED C3H; OXIDATION-REDUCTION; PHOTOBIOLOGY; PHOTOCHEMISTRY; SKIN; ULTRAVIOLET RAYS; VITAMIN E;

ANIMALIA;

EID: 0032972609     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx980204h     Document Type: Article

References (16)

1. Bisset, D. L., Chatterjee, R., and Hannon, D. P. (1990) Photoprotective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse. Photodermatol. Photoimmunol. Photomed. 7, 56-62.
2. Gensler, H. L., and Magdaleno, M. (1991) Topical vitamin E inhibition of immunosuppression and tumorigenesis induced by ultraviolet radiation. Nutr. Cancer 15, 97-106.
3. Liebler, D. C. (1993) The role of metabolism in the antioxidant function of vitamin E. CRC Crit. Rev. Toxicol. 23, 147-169.
4. Fryer, M. J. (1993) Evidence for the photoprotective effects of vitamin E. Photochem. Photobiol. 58, 304-312.
5. Weber, C., Podda, M., Rallis, M., Thiele, J. J., Traber, M. G., and Packer, L. (1997) Efficacy of topically applied tocopherols and tocotrienols in protection of murine skin from oxidative damage induced by UV-irradiation. Free Radical Biol. Med. 22, 761-769.
6. Shindo, Y., Witt, E., and Packer, L. (1993) Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light. J. Invest. Dermatol. 100, 260-265.
7. Fuchs, J., Huflejt, M. E., Rothfuss, L. M., Wilson, D. S., Carcamo, R., and Packer, L. (1989) Impairment of enzymic and nonenzymic antioxidants in skin by UVB irradiation. J. Invest. Dermatol. 93, 769-773.
8. Kramer, K. A., and Liebler, D. C. (1997) UVB induced photooxidation of vitamin E. Chem. Res. Toxicol. 10, 219-224.
9. Liebler, D. C., Burr, J. A., Philips, L., and Ham, A. J. L. (1996) Gas chromatography-mass spectrometry analysis of vitamin E and its oxidation products. Anal. Biochem. 236, 27-34.
10. Liebler, D. C., Baker, P. F., and Burr, J. A. (1990) Oxidaton of vitamin E: Evidence for competing autoxidation and peroxyl radical trapping reactions of the tocopheroxyl radical. J. Am. Chem. Soc. 112, 6995-7000.
11. Nelan, D. R., and Robeson, C. D. (1962) The oxidation product from α-tocopherol and potassium ferricyanide and its reaction with ascorbic and hydrochloric acids. J. Am. Chem. Soc. 84, 2963-2965.
12. Skinner, W. A., and Alaupovic, P. (1963) Oxidation products of vitamin E and its model, 6-hydroxy-2,2,5,7,8-pentamethyl-chroman. V. Studies of the products of alkaline ferricyanide oxidation. J. Org. Chem. 28, 2854-2858.
13. Thompson, S., and Slaga, T. J. (1976) Mouse epidermal aryl hydrocarbon hydroxylase. J. Invest. Dermatol. 66, 108-111.
14. McVean, M., and Liebler, D. C. (1997) Inhibition of UVB induced photodamage in mouse epidermis by topically applied α-tocopherol. Carcinogenesis 18, 1617-1622.
15. Thiele, J., Traber, M. G., and Packer, L. (1998) Depletion of stratum corneum vitamin E: an early and sensitive in vivo marker of UV-induced photo-oxidation. J. Invest. Dermatol. 110, 756-761.
16. Traber, M. G., Rallis, M., Podda, M., Weber, C., Maibach, H. I., and Packer, L. (1998) Penetration and distribution of α-tocopherol, α-or γ-tocotrienols applied individually onto murine skin. Lipids 33, 87-91.