Effect of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (vesnarinone) on the growth of gastric cancer cell lines

Cancer Letters

Volumn 140, Issue 1-2, 1999, Pages 121-128

  Yokozaki, Hiroshi ^a   Ito, Reiko ^a   Ono, Shigehiro ^a   Hayashi, Ken ^a   Tahara, Eiichi ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Anti cancer; Gastric cancer; Quinolinone derivative; Vesnarinone

Indexed keywords

CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; GROWTH FACTOR; PIPERANOMETOZINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; STOMACH CANCER;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, NORTHERN; CARCINOMA; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL NUCLEUS; HUMANS; QUINOLINES; RNA, MESSENGER; STOMACH NEOPLASMS; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0032972023     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00061-0     Document Type: Article

References (42)

1. Aoki K. Epidemiology of stomach cancer. Nishi M., Ichikawa H., Nakajima T., Maruyama K., Tahara E. Gastric Cancer. 1993;2-15 Springer, Tokyo.
2. Feldman A.M., Bristow M.R., Parmley W.W., Carson P.E., Pepine C.J., Gilbert E.M., Strobeck J.E., Hendrix G.H., Powers E.R., Bain R.P., White B.G. Effects of vesnarinone on morbidity and mortality in patients with heart failure. N. Engl. J. Med. 329:1993;149-155.
3. 2+-independent vasorelaxation induced by cardiotonic phosphodiesterase inhibitors. Eur. J. Pharmacol. 240:1993;57-66.
4. 2+ in cultured smooth muscle cells from porcine coronary artery. Jpn. Heart J. 35:1994;61-71.
5. Rapundalo S.T., Lathrop D.A., Harrison S.A., Beavo J.A., Schwartz A. Cyclic AMP-dependent and cyclic AMP-independent actions of a novel cardiotonic agent, OPC-8212. Naunyn Schmiedebergs Arch. Pharmakol. 338:1988;692-698.
6. Masuoka H., Ito M., Sugioka M., Kozeki H., Konishi T., Tanaka T., Nakano T. Two isoforms of cGMP-inhibited cyclic nucleotide phosphodiesterases in human tissues distinguished by their responses to vesnarinone, a new cardiotonic agent. Biochem. Biophys. Res. Commun. 190:1993;412-417.
7. Maruyama I., Maruyama Y., Nakajima T., Kitajima I., Osame M., Zhao J.-Q., Chen I.S.Y., Nakai S., Ikeda M., Yabu-uchi Y., Adachi M. Vesnarinone inhibits production of HIV-1 in cultured cells. Biochem. Biophys. Res. Commun. 195:1993;1264-1271.
8. Shioi T., Matsumori A., Matsui S., Sasayama S. Inhibition of cytokine production by a new inotropic agent, vesnarinone, in human lymphocytes, T cell line, and monocytic cell line. Life Sci. 54:1994;PL11-PL16.
9. Kumakura T., Takase K., Terada N., Gelfand E.W. Vesnarinone inhibits nucleoside and nucleobase transport. Life Sci. 57:1995;PL75-PL81.
10. Sato M., Harada K., Bando T., Shirakami T., Nakashiro K., Yoshida H., Nakai S., Kawai K., Adachi M. Characteristics of antitumor activity of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (vesnarinone) against a human adenoid squamous carcinoma-forming cell line grown in athymic nude mice. Cancer Lett. 91:1995;1-9.
11. Sato S., Tomoyasu S., Okabe-Kado J., Hozumi M., Tsuruoka N., Nakai S., Adachi M., Honma Y. Induction of differentiation and enhancement of vincristine sensitivity of human erythroleukemia HEL cells by vesnarinone, a positive inotropic agent. Exp. Hematol. 24:1996;37-42.
12. Nio Y., Ohmori H., Minari Y., Hirahara N., Sasaki S., Takamura M., Tamura K. A quinolinone derivative, vesnarinone (OPC-8212), significantly inhibits the in vitro and in vivo growth of human pancreatic cancer cell lines. Anticancer Drugs. 8:1997;686-695.
13. Kawai I., Konishi Y., Izumi K., Sato M., Adachi M., Hozumi M. Enhancement of anticancer effects of radiation and conventional anticancer agents by a quinolinone derivative, vesnarinone: studies on human gastric cancer tissue xenografts in nude mice. Anticancer Res. 18:1998;405-412.
14. Ochiai A., Yasui W., Tahara E. Growth-promoting effect of gastrin on human gastric carcinoma cell line TMK-1. Jpn. J. Cancer Res. 76:1985;1064-1071.
15. Hojo H. Establishment of culture cell lines of human stomach cancer: origin and their morphological characteristics. Niigata Med. J. 91:1977;737-752.
16. Motoyama T., Hojo H., Watanabe H. Comparison of seven cell lines derived from human gastric carcinomas. Acta Pathol. Jpn. 36:1986;65-83.
17. Mattar R., Yokozaki H., Yasui W., Ito H., Tahara E. p53 gene mutation in gastric cancer cell lines. Life Sci. Adv. Oncol. 11:1992;7-12.
18. Yokozaki H., Tortora G., Pepe S., Maronde E., Genieser H.-G., Jastorff B., Cho-Chung Y.S. Unhydrolyzable analogues of adenosine 3′:5′-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res. 52:1992;2504-2508.
19. Yanagihara K., Tsumuraya M. Growth factor β1 induces apoptotic cell death in cultured human gastric carcinoma cells. Cancer Res. 52:1992;4042-4045.
20. Yokozaki H., Budillon A., Tortora G., Meissner S., Beaucage S.L., Miki K., Cho-Chung Y.S. An antisense oligodeoxynucleotide that depletes RIα subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells. Cancer Res. 53:1993;868-872.
21. Wang J., Chenivesse X., Henglein B., Bréchot C. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature. 343:1990;555-557.
22. Lew D.J., Dulic V., Reed S.I. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. 66:1991;1197-1206.
23. Tsai L.-H., Harlow E., Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature. 353:1991;174-177.
24. Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., Smith J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:1994;90-98.
25. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 78:1994;59-66.
26. Harlow E., Williamson N.M., Ralston R., Helfman D.M., Adams T.E. Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53. Mol. Cell. Biol. 5:1985;1601-1610.
27. Derynck R., Roberts A.B., Winkler M.E., Chen E.Y., Goeddel D.V. Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell. 38:1984;287-297.
28. Derynck R., Jarrett J.A., Chen E.Y., Eaton D.H., Bell J.R., Assoian R.K., Roberts A.B., Sporn M.B., Goeddel D.V. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature. 316:1985;701-705.
29. Plowman G.D., Green J.M., McDonald V.L., Neubauer M.G., Disteche C.M., Todaro G.J., Shoyab M. The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Mol. Cell. Biol. 10:1990;1969-1981.
30. Furutani Y., Notake M., Yamayoshi M., Yamagishi J., Nomura H., Ohue M., Furuta R., Fukui T., Yamada M., Nakamura S. Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor. Nucleic Acids Res. 13:1985;5869-5882.
31. Yamamoto T., Ikawa S., Akiyama T., Semba K., Nomura N., Miyajima N., Saito T., Toyoshima K. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature. 319:1986;230-234.
32. Franzen P., ten Dijke P., Ichijo H., Yamashita H., Schulz P., Heldin C.H., Miyazono K. Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor. Cell. 75:1993;681-692.
33. Lin H.Y., Wang X.-F., Ng-Eaton E., Weinberg R.A., Lodish H.F. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell. 68:1992;775-785.
34. Kageyama R., Pastan I. Molecular cloning and characterization of a human DNA binding factor that represses transcription. Cell. 59:1989;815-825.
35. Akagi M., Yasui W., Akama Y., Yokozaki H., Tahara H., Haruma K., Kajiyama G., Tahara E. Inhibition of cell growth by transforming growth factor β1 is associated with p53-independent induction of p21 in gastric carcinoma cells. Jpn. J. Cancer Res. 87:1996;377-384.
36. Barlat I., Henglein B., Plet A., Lamb N., Fernandez A., McKenzie F., Pouyssegur J., Vie A., Blanchard J.M. TGF-β1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways. Oncogene. 11:1995;1309-1318.
37. Mednieks M.I., Yokozaki H., Merlo G.R., Tortora G., Clair T., Ally S., Tahara E., Cho-Chung Y.S. Site-selective 8-Cl-cAMP which causes growth inhibition and differentiation increases DNA (CRE)-binding activity in cancer cells. FEBS Lett. 254:1989;83-88.
38. Takanashi A., Yasui W., Yoshida K., Yokozaki H., Saito D., Abe K., Urakami K., Miki K., Tahara E. Inhibitory effect of 8-chloro-cyclic adenosine 3′,5′-monophosphate on cell growth of gastric carcinoma cell lines. Jpn. J. Cancer Res. 82:1991;325-331.
39. Akama Y., Yasui W., Kuniyasu H., Yokozaki H., Akagi M., Tahara H., Ishikawa T., Tahara E. Genetic status and expression of the cyclin-dependent kinase inhibitors in human gastric carcinoma cell lines. Jpn. J. Cancer Res. 87:1996;824-830.
40. Yanagawa T., Hayashi Y., Yoshida H., Yura Y., Nagamine S., Bando T., Sato M. An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. Am. J. Pathol. 124:1986;496-509.
41. Tahara E. Growth factors and oncogenes in human gastrointestinal carcinomas. J. Cancer Res. Clin. Oncol. 116:1990;121-131.
42. Ito R., Kitadai Y., Kyo E., Yokozaki H., Yasui W., Yamashita U., Nakai H., Tahara E. Interleukin 1α acts as an autocrine growth stimulator for human gastric carcinoma cells. Cancer Res. 53:1993;4102-4106.