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Volumn 11, Issue 3, 1999, Pages 225-243

Neutralising antibodies to interferon-β in the treatment of multiple sclerosis: Cause for concern?

Author keywords

[No Author keywords available]

Indexed keywords

BETA1A INTERFERON; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

EID: 0032971859     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-199911030-00006     Document Type: Review
Times cited : (13)

References (110)
  • 1
    • 0023159806 scopus 로고
    • Interferons and their actions
    • Pestka S, Langer JA. Interferons and their actions. Annu Rev Biochem 1987; 56: 727-77
    • (1987) Annu Rev Biochem , vol.56 , pp. 727-777
    • Pestka, S.1    Langer, J.A.2
  • 2
    • 0023839168 scopus 로고
    • Immunotherapy of multiple sclerosis
    • Weiner HL, Hafler DA. Immunotherapy of multiple sclerosis. Ann Neurol 1988; 23: 211-22
    • (1988) Ann Neurol , vol.23 , pp. 211-222
    • Weiner, H.L.1    Hafler, D.A.2
  • 4
    • 0021856495 scopus 로고
    • Clinical viral infections and multiple sclerosis
    • Sibley WA, Bamford CR, Clark K. Clinical viral infections and multiple sclerosis. Lancet 1985; 1: 1313-5
    • (1985) Lancet , vol.1 , pp. 1313-1315
    • Sibley, W.A.1    Bamford, C.R.2    Clark, K.3
  • 5
    • 0000201902 scopus 로고
    • Upper respiratory tract infections trigger attacks of multiple sclerosis in patients treated with interferon
    • Panitch HS, Bever CT, Katz E, et al. Upper respiratory tract infections trigger attacks of multiple sclerosis in patients treated with interferon [abstract]. J Neuroimmunol 1992; 35 Suppl. 1: 125
    • (1992) J Neuroimmunol , vol.35 , Issue.SUPPL. 1 , pp. 125
    • Panitch, H.S.1    Bever, C.T.2    Katz, E.3
  • 6
    • 0002171873 scopus 로고
    • Evidence for a viral etiology of multiple sclerosis
    • Cook SD, editor. New York: Marcel Dekker
    • Booss J, Kim JH. Evidence for a viral etiology of multiple sclerosis. In: Cook SD, editor. Handbook of multiple sclerosis. New York: Marcel Dekker, 1990: 41-61
    • (1990) Handbook of Multiple Sclerosis , pp. 41-61
    • Booss, J.1    Kim, J.H.2
  • 7
    • 0018974690 scopus 로고
    • Multiple sclerosis and viruses: An overview
    • Cook SD, Dowling PC. Multiple sclerosis and viruses: an overview. Neurology 1980; 30: 80-91
    • (1980) Neurology , vol.30 , pp. 80-91
    • Cook, S.D.1    Dowling, P.C.2
  • 8
    • 0025376448 scopus 로고
    • Immunology of multiple sclerosis
    • Dhib-Jalbut S, McFarlin DE. Immunology of multiple sclerosis. Ann Allerg 1989; 64: 433-44
    • (1989) Ann Allerg , vol.64 , pp. 433-444
    • Dhib-Jalbut, S.1    McFarlin, D.E.2
  • 10
    • 0020004747 scopus 로고
    • Decreased NK killing in patients with multiple sclerosis: An analysis at the level of the single effector cell in peripheral blood and cerebrospinal fluid in relation to the activity of the disease
    • Merrill J, Jondal M, Seeley J, et al. Decreased NK killing in patients with multiple sclerosis: an analysis at the level of the single effector cell in peripheral blood and cerebrospinal fluid in relation to the activity of the disease. Clin Exp Immunol 1982; 47: 419-30
    • (1982) Clin Exp Immunol , vol.47 , pp. 419-430
    • Merrill, J.1    Jondal, M.2    Seeley, J.3
  • 11
    • 0019977128 scopus 로고
    • Endogenous and interferon-augmented natural killer cell activity of human peripheral blood mononuclear cells in vitro: Studies of patients with MS, SLE and rheumatoid arthritis
    • Neighbour PA, Grayzel AI, Miller AE. Endogenous and interferon-augmented natural killer cell activity of human peripheral blood mononuclear cells in vitro: studies of patients with MS, SLE and rheumatoid arthritis. Clin Exp Immunol 1982; 49: 11-21
    • (1982) Clin Exp Immunol , vol.49 , pp. 11-21
    • Neighbour, P.A.1    Grayzel, A.I.2    Miller, A.E.3
  • 12
    • 0022595630 scopus 로고
    • Activated suppressor cell dysfunction in progressive multiple sclerosis
    • Antel JP, Bania MB, Reder A, et al. Activated suppressor cell dysfunction in progressive multiple sclerosis. J Immunol 1986; 137: 137-41
    • (1986) J Immunol , vol.137 , pp. 137-141
    • Antel, J.P.1    Bania, M.B.2    Reder, A.3
  • 13
    • 0022591776 scopus 로고
    • Defective autologous mixed lymphocyte reactivity in multiple sclerosis
    • Hirsch RL. Defective autologous mixed lymphocyte reactivity in multiple sclerosis. Clin Exp Immunol 1986; 64: 107-13
    • (1986) Clin Exp Immunol , vol.64 , pp. 107-113
    • Hirsch, R.L.1
  • 14
    • 1842390533 scopus 로고
    • Selective loss of a subset of T helper cells in active multiple sclerosis
    • Rose LM, Ginsberg AH, Rothstein TL, et al. Selective loss of a subset of T helper cells in active multiple sclerosis. Proc Natl Acad Sci USA 1985; 82: 7389-93
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 7389-7393
    • Rose, L.M.1    Ginsberg, A.H.2    Rothstein, T.L.3
  • 15
    • 0022462042 scopus 로고
    • Multiple sclerosis: Increased expression of interleukin-2 receptors on lymphocytes
    • Selmaj K, Platerzyberk C, Rockett KA, et al. Multiple sclerosis: increased expression of interleukin-2 receptors on lymphocytes. Neurology 1986; 36: 1392-5
    • (1986) Neurology , vol.36 , pp. 1392-1395
    • Selmaj, K.1    Platerzyberk, C.2    Rockett, K.A.3
  • 16
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing remitting multiple sclerosis. I. Clinical results of a multicenter, randomised, double-blind, placebo controlled trial
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing remitting multiple sclerosis. I. Clinical results of a multicenter, randomised, double-blind, placebo controlled trial. Neurology 1993; 43: 655-61
    • (1993) Neurology , vol.43 , pp. 655-661
  • 17
    • 0013565791 scopus 로고
    • Physiological studies in metrazol shock. VII. Anti-insulin activity of insulin-treated patients
    • Banting FG, Franks WR, Gaitus S. Physiological studies in metrazol shock. VII. Anti-insulin activity of insulin-treated patients. Am J Psychiat 1938; 95: 562-6
    • (1938) Am J Psychiat , vol.95 , pp. 562-566
    • Banting, F.G.1    Franks, W.R.2    Gaitus, S.3
  • 18
    • 0013594542 scopus 로고
    • Immunologic aspects of insulin
    • Yalow RS, Berson SA. Immunologic aspects of insulin. Am J Med 1961; 31: 882-91
    • (1961) Am J Med , vol.31 , pp. 882-891
    • Yalow, R.S.1    Berson, S.A.2
  • 19
    • 0000288456 scopus 로고
    • The antigenicity of insulin: A review
    • Prout TE. The antigenicity of insulin: a review. J Chron Dis 1962; 15: 879-85
    • (1962) J Chron Dis , vol.15 , pp. 879-885
    • Prout, T.E.1
  • 20
    • 0018552270 scopus 로고
    • Immunologic reactions to insulin: Insulin allergy, insulin resistance, and the autoimmune insulin syndrome
    • Kahn CR, Rosenthal AS. Immunologic reactions to insulin: insulin allergy, insulin resistance, and the autoimmune insulin syndrome. Diabetes Care 1979; 2: 283-95
    • (1979) Diabetes Care , vol.2 , pp. 283-295
    • Kahn, C.R.1    Rosenthal, A.S.2
  • 21
    • 0018974918 scopus 로고
    • Role of aggregated human growth hormone (hGH) in development of antibodies to hGH
    • Moore WV, Leppert P. Role of aggregated human growth hormone (hGH) in development of antibodies to hGH. J Clin Endocrinol Metab 1980; 51: 691-97
    • (1980) J Clin Endocrinol Metab , vol.51 , pp. 691-697
    • Moore, W.V.1    Leppert, P.2
  • 22
    • 0021955999 scopus 로고
    • Development of antibody to growth hormone-releasing factor
    • Thorner MD, Reschke J, Chitwood J, et al. Development of antibody to growth hormone-releasing factor. N Engl J Med 1985; 312: 994
    • (1985) N Engl J Med , vol.312 , pp. 994
    • Thorner, M.D.1    Reschke, J.2    Chitwood, J.3
  • 23
    • 0018434504 scopus 로고
    • Antibodies to blood coagulation factors
    • Shapiro SS. Antibodies to blood coagulation factors. Clin Haematol 1979; 8: 207-14
    • (1979) Clin Haematol , vol.8 , pp. 207-214
    • Shapiro, S.S.1
  • 24
    • 0020418338 scopus 로고
    • Development of IgE antibodies to human (recombinant DNA), porcine, and bovine insulins in diabetic subjects
    • Fireman P, Fineberg SE, Galloway JA. Development of IgE antibodies to human (recombinant DNA), porcine, and bovine insulins in diabetic subjects. Diabetes Care 1982; 5: 119-25
    • (1982) Diabetes Care , vol.5 , pp. 119-125
    • Fireman, P.1    Fineberg, S.E.2    Galloway, J.A.3
  • 25
    • 0020419292 scopus 로고
    • Insulin-specific IgG and IgE antibody response in type 1 diabetic subjects exclusively treated with human insulin (recombinant DNA)
    • Velcovsky HG, Federlin KF. Insulin-specific IgG and IgE antibody response in type 1 diabetic subjects exclusively treated with human insulin (recombinant DNA). Diabetes Care 1982; 5: 126-8
    • (1982) Diabetes Care , vol.5 , pp. 126-128
    • Velcovsky, H.G.1    Federlin, K.F.2
  • 26
    • 0019350115 scopus 로고
    • Interferon-neutralising antibodies in a patient treated with human fibroblast interferon
    • Vallbracht A, Treuner J, Flehmig B, et al. Interferon-neutralising antibodies in a patient treated with human fibroblast interferon. Nature 1981; 289: 496-7
    • (1981) Nature , vol.289 , pp. 496-497
    • Vallbracht, A.1    Treuner, J.2    Flehmig, B.3
  • 27
    • 0020004183 scopus 로고
    • Recombinant leukocyte A interferon: Pharmacokinetics, single-dose tolerance, and biologic effects in cancer patients
    • Gutterman JU, Fine S, Quesada J, et al. Recombinant leukocyte A interferon: pharmacokinetics, single-dose tolerance, and biologic effects in cancer patients. Ann Intern Med 1982; 96: 549-56
    • (1982) Ann Intern Med , vol.96 , pp. 549-556
    • Gutterman, J.U.1    Fine, S.2    Quesada, J.3
  • 28
    • 0022359745 scopus 로고
    • Antitumor activity of recombinant-derived interferon alpha in metastatic renal cell carcinoma
    • Quesada J, Rios A, Swanson D, et al. Antitumor activity of recombinant-derived interferon alpha in metastatic renal cell carcinoma. J Clin Oncol 1985; 11: 1522-8
    • (1985) J Clin Oncol , vol.11 , pp. 1522-1528
    • Quesada, J.1    Rios, A.2    Swanson, D.3
  • 29
    • 0013566018 scopus 로고
    • Recombinant leukocyte A interferon (rIFN-alpha-2a) antibody development in advanced renal cell carcinoma (RCC)
    • Figlin R, deKernion J, Mukamel E, et al. Recombinant leukocyte A interferon (rIFN-alpha-2a) antibody development in advanced renal cell carcinoma (RCC) [abstract]. Proc Am Soc Clin Oncol 1986; 5: 222
    • (1986) Proc Am Soc Clin Oncol , vol.5 , pp. 222
    • Figlin, R.1    DeKernion, J.2    Mukamel, E.3
  • 30
    • 0023296168 scopus 로고
    • Incidence and clinical significance of neutralising antibodies in patients receiving recombinant interferon alpha-2a by intramuscular injection
    • Itri L, Campion M, Dennin N, et al. Incidence and clinical significance of neutralising antibodies in patients receiving recombinant interferon alpha-2a by intramuscular injection. Cancer 1987; 59: 668-74
    • (1987) Cancer , vol.59 , pp. 668-674
    • Itri, L.1    Campion, M.2    Dennin, N.3
  • 31
    • 0013620910 scopus 로고
    • Alpha interferons in hairy cell leukemia (HCL): A five year follow up in 100 patients
    • Quesada J, Itri L, Gutterman J. Alpha interferons in hairy cell leukemia (HCL): a five year follow up in 100 patients [abstract]. J Interferon Res 1987; 7: 678
    • (1987) J Interferon Res , vol.7 , pp. 678
    • Quesada, J.1    Itri, L.2    Gutterman, J.3
  • 32
    • 0023625802 scopus 로고
    • Management of cancer patients receiving interferon alpha-2a
    • Gauci L. Management of cancer patients receiving interferon alpha-2a. Int J Cancer 1987; Suppl. 1: 21-30
    • (1987) Int J Cancer , Issue.SUPPL. 1 , pp. 21-30
    • Gauci, L.1
  • 33
    • 0023893064 scopus 로고
    • Resistance to recombinant interferon alpha-2a in hairy cell leukemia associated with neutralising anti-interferon antibodies
    • Steis RG, Smith JW H, Urba WJ, et al. Resistance to recombinant interferon alpha-2a in hairy cell leukemia associated with neutralising anti-interferon antibodies. N Engl J Med 1988; 318: 1409-13
    • (1988) N Engl J Med , vol.318 , pp. 1409-1413
    • Steis, R.G.1    Smith, J.W.H.2    Urba, W.J.3
  • 34
    • 0024729990 scopus 로고
    • Incidence and clinical significance of neutralising antibodies in patients receiving recombinant interferon-alpha-2a
    • Itri LM, Sherman MJ, Palleroni AV, et al. Incidence and clinical significance of neutralising antibodies in patients receiving recombinant interferon-alpha-2a. J Interferon Res 1989; 9 Suppl. 1: S9-15
    • (1989) J Interferon Res , vol.9 , Issue.SUPPL. 1
    • Itri, L.M.1    Sherman, M.J.2    Palleroni, A.V.3
  • 35
    • 0024563550 scopus 로고
    • Interferon antibodies in patients with chronic HBV infection treated with recombinant interferon
    • Porres JC, Carreno V, Ruis M, et al. Interferon antibodies in patients with chronic HBV infection treated with recombinant interferon. J Hepatol 1989; 8: 351-7
    • (1989) J Hepatol , vol.8 , pp. 351-357
    • Porres, J.C.1    Carreno, V.2    Ruis, M.3
  • 36
    • 0025607230 scopus 로고
    • Interferon antibodies may negate the antiviral effects of recombinant alpha-interferon treatment in patients with chronic hepatitis B virus infection
    • Lok SF, Lai CL, Leung KY. Interferon antibodies may negate the antiviral effects of recombinant alpha-interferon treatment in patients with chronic hepatitis B virus infection. Hepatology 1990; 12: 1266-70
    • (1990) Hepatology , vol.12 , pp. 1266-1270
    • Lok, S.F.1    Lai, C.L.2    Leung, K.Y.3
  • 37
    • 0028679078 scopus 로고
    • Comparative study of three doses of interferon-alpha-2a in chronic active hepatitis B
    • The International Hepatitis Trial Group
    • Thomas HC, Lok AS, Carreno V, et al. Comparative study of three doses of interferon-alpha-2a in chronic active hepatitis B. The International Hepatitis Trial Group. J Viral Hepatitis 1994; 1: 139-48
    • (1994) J Viral Hepatitis , vol.1 , pp. 139-148
    • Thomas, H.C.1    Lok, A.S.2    Carreno, V.3
  • 38
    • 0027981534 scopus 로고
    • Biological and clinical significance of neutralising and binding antibodies to interferon-alpha (IFN-alpha) during therapy for chronic hepatitis C
    • Giannelli G, Antonelli G, Fera G, et al. Biological and clinical significance of neutralising and binding antibodies to interferon-alpha (IFN-alpha) during therapy for chronic hepatitis C. Clin Exp Immunol 1994; 97: 4-9
    • (1994) Clin Exp Immunol , vol.97 , pp. 4-9
    • Giannelli, G.1    Antonelli, G.2    Fera, G.3
  • 39
    • 9044230923 scopus 로고    scopus 로고
    • Antibodies to interferon (IFN) in hepatitis C patients relapsing while continuing recombinant IFN-alpha-2 therapy
    • Antonelli G, Giannelli G, Currenti M, et al. Antibodies to interferon (IFN) in hepatitis C patients relapsing while continuing recombinant IFN-alpha-2 therapy. Clin Exp Immunol 1996; 104: 384-7
    • (1996) Clin Exp Immunol , vol.104 , pp. 384-387
    • Antonelli, G.1    Giannelli, G.2    Currenti, M.3
  • 40
    • 0024213417 scopus 로고
    • Anti-alpha interferon antibodies after alpha interferon treatment in patients with chronic viral hepatitis
    • Craxi A, Di Marco V, Volpes R, et al. Anti-alpha interferon antibodies after alpha interferon treatment in patients with chronic viral hepatitis. Hepatogastroenterology 1988; 35: 304-5
    • (1988) Hepatogastroenterology , vol.35 , pp. 304-305
    • Craxi, A.1    Di Marco, V.2    Volpes, R.3
  • 41
    • 0022587054 scopus 로고
    • Low incidence of serum neutralising factors in patients receiving recombinant alpha-2b interferon (Intron A)
    • Spiegel RJ, Spicehandler JR, Jacobs SL, et al. Low incidence of serum neutralising factors in patients receiving recombinant alpha-2b interferon (Intron A). Am J Med 1986; 80: 223-8
    • (1986) Am J Med , vol.80 , pp. 223-228
    • Spiegel, R.J.1    Spicehandler, J.R.2    Jacobs, S.L.3
  • 42
    • 0023181834 scopus 로고
    • The alpha interferons: Clinical overview
    • Spiegel R. The alpha interferons: clinical overview. Semin Oncol 1987; 14: 1-12
    • (1987) Semin Oncol , vol.14 , pp. 1-12
    • Spiegel, R.1
  • 43
    • 0023220630 scopus 로고
    • Alpha-2b interferon in the treatment of Hodgkin's disease and non-Hodgkin's lymphoma
    • Leavitt R, Ratanantharathorn V, Ozer H, et al. Alpha-2b interferon in the treatment of Hodgkin's disease and non-Hodgkin's lymphoma. Semin Oncol 1987; 14: 18-23
    • (1987) Semin Oncol , vol.14 , pp. 18-23
    • Leavitt, R.1    Ratanantharathorn, V.2    Ozer, H.3
  • 44
    • 0023651968 scopus 로고
    • Clinical significance of anti-interferon titres during interferon therapy
    • Von Wussow P, Freund M, Block B, et al. Clinical significance of anti-interferon titres during interferon therapy. Lancet 1987; 2: 635-6
    • (1987) Lancet , vol.2 , pp. 635-636
    • Von Wussow, P.1    Freund, M.2    Block, B.3
  • 45
    • 0023936183 scopus 로고
    • Randomised study of the duration of treatment with interferon alpha-2b in patients with hairy cell leukemia
    • Golomb H, Ratain M, Fefer A, et al. Randomised study of the duration of treatment with interferon alpha-2b in patients with hairy cell leukemia. J Natl Cancer Inst 1988; 80: 369-73
    • (1988) J Natl Cancer Inst , vol.80 , pp. 369-373
    • Golomb, H.1    Ratain, M.2    Fefer, A.3
  • 46
    • 4243436934 scopus 로고
    • Long-term treatment with alpha interferons of patients with malignant carcinoid tumors - The six year experience
    • Oberg K. Long-term treatment with alpha interferons of patients with malignant carcinoid tumors - the six year experience [abstract]. J Interferon Res 1988; 8: S22
    • (1988) J Interferon Res , vol.8
    • Oberg, K.1
  • 47
    • 0024402892 scopus 로고
    • Recombinant human interferon (IFN) alpha-2b in chronic myelogenous leukemia: Dose dependency of response and frequency of neutralising anti-interferon antibodies
    • Freund M, Von Wussow P, Diedrich H, et al. Recombinant human interferon (IFN) alpha-2b in chronic myelogenous leukemia: dose dependency of response and frequency of neutralising anti-interferon antibodies. Br J Haematol 1989; 72: 350-6
    • (1989) Br J Haematol , vol.72 , pp. 350-356
    • Freund, M.1    Von Wussow, P.2    Diedrich, H.3
  • 48
    • 0024726169 scopus 로고
    • Detection and incidence of neutralising antibodies to interferon-alpha-n1
    • Weck PK, Leventhal BG, Brand C, et al. Detection and incidence of neutralising antibodies to interferon-alpha-n1. J Interferon Res 1989; 9 Suppl. 1: S37-43
    • (1989) J Interferon Res , vol.9 , Issue.SUPPL. 1
    • Weck, P.K.1    Leventhal, B.G.2    Brand, C.3
  • 49
    • 0021173394 scopus 로고
    • Systemic alpha-interferon therapy of multiple sclerosis
    • Knobler RL, Panitch HS, Braheny SL, et al. Systemic alpha-interferon therapy of multiple sclerosis. Neurology 1984; 34: 1273-9
    • (1984) Neurology , vol.34 , pp. 1273-1279
    • Knobler, R.L.1    Panitch, H.S.2    Braheny, S.L.3
  • 50
    • 0023191664 scopus 로고
    • Systemic alpha-interferon in multiple sclerosis
    • Panitch HS. Systemic alpha-interferon in multiple sclerosis. Arch Neurol 1987; 44: 61-3
    • (1987) Arch Neurol , vol.44 , pp. 61-63
    • Panitch, H.S.1
  • 51
    • 0024406788 scopus 로고
    • Interferon-alpha and transfer factor in the treatment of multiple sclerosis: A double-blind, placebo-controlled trial
    • AUSTIMS Research Group. Interferon-alpha and transfer factor in the treatment of multiple sclerosis: a double-blind, placebo-controlled trial. J Neurol Neurosurg Psychiatry 1989; 52: 566-74
    • (1989) J Neurol Neurosurg Psychiatry , vol.52 , pp. 566-574
  • 52
    • 0023039442 scopus 로고
    • Systemic recombinant alpha-2 interferon therapy in relapsing multiple sclerosis
    • Camenga DL, Johnson KP, Alter M, et al. Systemic recombinant alpha-2 interferon therapy in relapsing multiple sclerosis. Arch Neurol 1986; 43: 1239-46
    • (1986) Arch Neurol , vol.43 , pp. 1239-1246
    • Camenga, D.L.1    Johnson, K.P.2    Alter, M.3
  • 53
    • 0028348216 scopus 로고
    • Chronic systemic high-dose recombinant interferon alpha-2a reduces exacerbation rate, MRI signs of disease activity, and lymphocyte interferon gamma production in relapsing-remitting multiple sclerosis
    • Durelli L, Bongioanni MR, Cavallo R, et al. Chronic systemic high-dose recombinant interferon alpha-2a reduces exacerbation rate, MRI signs of disease activity, and lymphocyte interferon gamma production in relapsing-remitting multiple sclerosis. Neurology 1994; 44: 406-13
    • (1994) Neurology , vol.44 , pp. 406-413
    • Durelli, L.1    Bongioanni, M.R.2    Cavallo, R.3
  • 54
    • 0025238999 scopus 로고
    • Systemic lymphoblastoid interferon therapy in chronic progressive multiple sclerosis. I. Clinical and MRI evaluation
    • Kastrukoff LF, Oger J, Hashimoto SA, et al. Systemic lymphoblastoid interferon therapy in chronic progressive multiple sclerosis. I. Clinical and MRI evaluation. Neurology 1990; 40: 479-86
    • (1990) Neurology , vol.40 , pp. 479-486
    • Kastrukoff, L.F.1    Oger, J.2    Hashimoto, S.A.3
  • 55
    • 0027156946 scopus 로고
    • Effects of recombinant alpha-2b interferon therapy in patients with progressive MS
    • Kinnunen E, Timonen T, Pirttila T, et al. Effects of recombinant alpha-2b interferon therapy in patients with progressive MS. Acta Neurol Scand 1993; 87: 457-60
    • (1993) Acta Neurol Scand , vol.87 , pp. 457-460
    • Kinnunen, E.1    Timonen, T.2    Pirttila, T.3
  • 56
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
    • Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol 1996; 39: 285-94
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 57
    • 0031841745 scopus 로고    scopus 로고
    • Incidence and significance of neutralising antibodies in interferon beta-1a in multiple sclerosis
    • Rudick RA, Simonian NA, Alam JA, et al. Incidence and significance of neutralising antibodies in interferon beta-1a in multiple sclerosis. Neurology 1998; 50: 1266-72
    • (1998) Neurology , vol.50 , pp. 1266-1272
    • Rudick, R.A.1    Simonian, N.A.2    Alam, J.A.3
  • 58
    • 0029827192 scopus 로고    scopus 로고
    • Recombinant human interferon-beta (rHuIFN-beta) and radiation therapy for inoperable non-small cell lung cancer
    • Byhardt RW, Vaickus L, Witt PL, et al. Recombinant human interferon-beta (rHuIFN-beta) and radiation therapy for inoperable non-small cell lung cancer. J Interferon Cytokine Res 1996; 16: 891-902
    • (1996) J Interferon Cytokine Res , vol.16 , pp. 891-902
    • Byhardt, R.W.1    Vaickus, L.2    Witt, P.L.3
  • 59
    • 0030879839 scopus 로고    scopus 로고
    • Recombinant human interferon-beta for condylomata acuminata: A randomised, double-blind, placebo-controlled study of intralesional therapy
    • Bornstein J, Pasal B, Zarfati D, et al. Recombinant human interferon-beta for condylomata acuminata: a randomised, double-blind, placebo-controlled study of intralesional therapy. Int J STD AIDS 1997; 8: 614-21
    • (1997) Int J STD AIDS , vol.8 , pp. 614-621
    • Bornstein, J.1    Pasal, B.2    Zarfati, D.3
  • 60
    • 9844227905 scopus 로고    scopus 로고
    • Recombinant human interferon-beta in the treatment of condylomata acuminata
    • Dinsmore W, Jordan J, O'Mahony C, et al. Recombinant human interferon-beta in the treatment of condylomata acuminata. Int J STD AIDS 1997; 8: 622-8
    • (1997) Int J STD AIDS , vol.8 , pp. 622-628
    • Dinsmore, W.1    Jordan, J.2    O'Mahony, C.3
  • 61
    • 0030823454 scopus 로고    scopus 로고
    • Incidence of antibodies to interferon-beta in patients treated with recombinant human interferon-beta-1a from mammalian cells
    • Abdul-Ahad AK, Galazka AR, Revel M, et al. Incidence of antibodies to interferon-beta in patients treated with recombinant human interferon-beta-1a from mammalian cells. Cytokines Cell Mol Ther 1997; 3: 27-32
    • (1997) Cytokines Cell Mol Ther , vol.3 , pp. 27-32
    • Abdul-Ahad, A.K.1    Galazka, A.R.2    Revel, M.3
  • 62
    • 85086810415 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with interferon beta-1a
    • Abdul-Ahad AK, Shah S, Galazka A. Treatment of multiple sclerosis with interferon beta-1a. Neurology 1997; 49: 641
    • (1997) Neurology , vol.49 , pp. 641
    • Abdul-Ahad, A.K.1    Shah, S.2    Galazka, A.3
  • 63
    • 0345601517 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled study of interferon beta 1a in relapsing-remitting multiple sclerosis
    • The PRISMS Study Group. Randomised, double-blind, placebo-controlled study of interferon beta 1a in relapsing-remitting multiple sclerosis. Lancet 1998; 352: 1498-504
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 64
    • 0031978274 scopus 로고    scopus 로고
    • Development of neutralizing antibodies in patients with relapsing-remitting multiple sclerosis treated with IFNβ-1a
    • Antonelli G, Bagnato F, Pozzilli C, et al. Development of neutralizing antibodies in patients with relapsing-remitting multiple sclerosis treated with IFNβ-1a. J Interferon Cytokine Res 1998; 18: 345-50
    • (1998) J Interferon Cytokine Res , vol.18 , pp. 345-350
    • Antonelli, G.1    Bagnato, F.2    Pozzilli, C.3
  • 65
    • 0022455463 scopus 로고
    • Phase I/II trial of human recombinant beta-interferon serine in patients with renal cell carcinoma
    • Rinehart J, Malspeis L, Young D, et al. Phase I/II trial of human recombinant beta-interferon serine in patients with renal cell carcinoma. Cancer Res 1986; 46: 5364-7
    • (1986) Cancer Res , vol.46 , pp. 5364-5367
    • Rinehart, J.1    Malspeis, L.2    Young, D.3
  • 66
    • 0006511559 scopus 로고
    • Assessment of the antigenic response in humans to a recombinant mutant interferon beta
    • Konrad MW, Childs AL, Merigan TC, et al. Assessment of the antigenic response in humans to a recombinant mutant interferon beta. J Clin Immunol 1987; 7: 365-75
    • (1987) J Clin Immunol , vol.7 , pp. 365-375
    • Konrad, M.W.1    Childs, A.L.2    Merigan, T.C.3
  • 67
    • 0024724256 scopus 로고
    • Evaluation of neutralising antibodies in patients treated with recombinant interferon-beta(ser)
    • Larocca AP, Leung SC, Marcus SG, et al. Evaluation of neutralising antibodies in patients treated with recombinant interferon-beta(ser). J Interferon Res 1989; 9 Suppl. 1: S51-60
    • (1989) J Interferon Res , vol.9 , Issue.SUPPL. 1
    • Larocca, A.P.1    Leung, S.C.2    Marcus, S.G.3
  • 68
    • 17644436776 scopus 로고
    • Systemic recombinant human interferon-beta treatment of relapsing-remitting multiple sclerosis: Pilot study analysis and six-year follow-up
    • Knobler RL, Greenstein JI, Johnson KP, et al. Systemic recombinant human interferon-beta treatment of relapsing-remitting multiple sclerosis: pilot study analysis and six-year follow-up. J Interferon Res 1993; 13: 333-40
    • (1993) J Interferon Res , vol.13 , pp. 333-340
    • Knobler, R.L.1    Greenstein, J.I.2    Johnson, K.P.3
  • 69
    • 0005489101 scopus 로고    scopus 로고
    • Neutralising antibodies during treatment of multiple sclerosis with interferon beta-1b: Experience during the first three years
    • The IFNB Multiple Sclerosis Study Group and the UBC MS/MRI Analysis Group. Neutralising antibodies during treatment of multiple sclerosis with interferon beta-1b: experience during the first three years. Neurology 1996; 47: 889-94
    • (1996) Neurology , vol.47 , pp. 889-894
  • 70
    • 0030770887 scopus 로고    scopus 로고
    • Neutralising and binding anti-interferon-beta-1b (IFN-beta-1b) antibodies during IFN-beta-1b treatment of multiple sclerosis
    • Kivisakk P, Ahn GV, Tian WZ, et al. Neutralising and binding anti-interferon-beta-1b (IFN-beta-1b) antibodies during IFN-beta-1b treatment of multiple sclerosis. Mult Scler 1997; 3: 184-90
    • (1997) Mult Scler , vol.3 , pp. 184-190
    • Kivisakk, P.1    Ahn, G.V.2    Tian, W.Z.3
  • 71
    • 0032494792 scopus 로고    scopus 로고
    • Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis
    • European Study Group on Interferon β-1b in Secondary Progressive MS. Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis. Lancet 1998; 352: 1491-7
    • (1998) Lancet , vol.352 , pp. 1491-1497
  • 72
    • 0024329242 scopus 로고
    • Intravesical treatment of bladder cancer with recombinant human interferon-beta: Intravesical GKT-beta Chemotherapy Research Group
    • Niijima T, Umeda T, Kuriyama M, et al. Intravesical treatment of bladder cancer with recombinant human interferon-beta: Intravesical GKT-beta Chemotherapy Research Group. Cancer Immunol Immunother 1989; 30: 81-5
    • (1989) Cancer Immunol Immunother , vol.30 , pp. 81-85
    • Niijima, T.1    Umeda, T.2    Kuriyama, M.3
  • 73
    • 0026331223 scopus 로고
    • Formation of neutralising antibodies against natural interferon-beta, but not against recombinant interferon-gamma, during adjuvant therapy for high risk malignant melanoma patients
    • Dummer R, Muller W, Nestle F, et al. Formation of neutralising antibodies against natural interferon-beta, but not against recombinant interferon-gamma, during adjuvant therapy for high risk malignant melanoma patients. Cancer 1991; 67: 2300-4
    • (1991) Cancer , vol.67 , pp. 2300-2304
    • Dummer, R.1    Muller, W.2    Nestle, F.3
  • 74
    • 0027946071 scopus 로고
    • Neutralising interferon-beta antibodies in melanoma patients treated with recombinant and natural interferon beta
    • Fierlbeck G, Schreiner T, Schaber B, et al. Neutralising interferon-beta antibodies in melanoma patients treated with recombinant and natural interferon beta. Cancer Immunol Immunother 1994; 39: 263-8
    • (1994) Cancer Immunol Immunother , vol.39 , pp. 263-268
    • Fierlbeck, G.1    Schreiner, T.2    Schaber, B.3
  • 75
  • 76
    • 0017855308 scopus 로고
    • DNA and RNA antibodies in serum and CSF of multiple sclerosis and subacute sclerosing panencephalitis patients
    • Schuller E, Delasnerie N, Lebon P. DNA and RNA antibodies in serum and CSF of multiple sclerosis and subacute sclerosing panencephalitis patients. J Neurol Sci 1978; 37: 31-6
    • (1978) J Neurol Sci , vol.37 , pp. 31-36
    • Schuller, E.1    Delasnerie, N.2    Lebon, P.3
  • 77
    • 0018870413 scopus 로고
    • Measles-specific antibodies in sera and cerebrospinal fluids of patients with multiple sclerosis
    • Hayes EC, Gollovin SD, Machamer CE, et al. Measles-specific antibodies in sera and cerebrospinal fluids of patients with multiple sclerosis. Infect Immun 1980; 27: 1033-7
    • (1980) Infect Immun , vol.27 , pp. 1033-1037
    • Hayes, E.C.1    Gollovin, S.D.2    Machamer, C.E.3
  • 78
    • 0019349655 scopus 로고
    • Antibodies to viral and non-viral antigens in subacute sclerosing panencephalitis and multiple sclerosis demonstrated by thin-layer polyacrylamide gel isoelectric focusing, antigen immunofixation and autoradiography
    • Shorr J, Rostrom B, Link H. Antibodies to viral and non-viral antigens in subacute sclerosing panencephalitis and multiple sclerosis demonstrated by thin-layer polyacrylamide gel isoelectric focusing, antigen immunofixation and autoradiography. J Neurol Sci 1981; 49: 99-108
    • (1981) J Neurol Sci , vol.49 , pp. 99-108
    • Shorr, J.1    Rostrom, B.2    Link, H.3
  • 79
    • 0020522828 scopus 로고
    • Intrathecal antibody synthesis to virus antigens in multiple sclerosis
    • Salmi A, Reunanen M, Ilonen J, et al. Intrathecal antibody synthesis to virus antigens in multiple sclerosis. Clin Exp Immunol 1983; 52: 241-9
    • (1983) Clin Exp Immunol , vol.52 , pp. 241-249
    • Salmi, A.1    Reunanen, M.2    Ilonen, J.3
  • 80
    • 0021949843 scopus 로고
    • Epstein-Barr nuclear antigen and viral capsid antigen antibody titers in multiple sclerosis
    • Larsen PD, Bloomer LC, Bray PF. Epstein-Barr nuclear antigen and viral capsid antigen antibody titers in multiple sclerosis. Neurology 1985; 35: 435-8
    • (1985) Neurology , vol.35 , pp. 435-438
    • Larsen, P.D.1    Bloomer, L.C.2    Bray, P.F.3
  • 81
    • 0023515435 scopus 로고
    • Viral antibody titers: Comparison in patients with multiple sclerosis and rheumatoid arthritis
    • Shirodaria PV, Haire M, Fleming E, et al. Viral antibody titers: comparison in patients with multiple sclerosis and rheumatoid arthritis. Arch Neurol 1987; 44: 1237-41
    • (1987) Arch Neurol , vol.44 , pp. 1237-1241
    • Shirodaria, P.V.1    Haire, M.2    Fleming, E.3
  • 82
    • 0020801811 scopus 로고
    • Immunology of multiple sclerosis
    • Oger J, Roos R, Antel JP. Immunology of multiple sclerosis. Neurol Clin N Am 1983; 1 (3): 655-79
    • (1983) Neurol Clin N Am , vol.1 , Issue.3 , pp. 655-679
    • Oger, J.1    Roos, R.2    Antel, J.P.3
  • 83
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomised, double-blind, placebo-controlled trial
    • Paty DW, Li DKB, UBC MS/MRI Study Group, IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomised, double-blind, placebo-controlled trial. Neurology 1993; 43: 662-7
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.W.1    Li, D.K.B.2
  • 84
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomised controlled trial
    • The IFNB Multiple Sclerosis Study Group. University of British Columbia MS/MRI Analysis Group. Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomised controlled trial. Neurology 1995; 45: 1277-85
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 85
    • 6844250787 scopus 로고    scopus 로고
    • Magnetic resonance studies of intramuscular interferon beta-1a for relapsing multiple sclerosis
    • Simon JH, Jacobs LD, Campion M, et al. Magnetic resonance studies of intramuscular interferon beta-1a for relapsing multiple sclerosis. Ann Neurol 1998; 43: 79-87
    • (1998) Ann Neurol , vol.43 , pp. 79-87
    • Simon, J.H.1    Jacobs, L.D.2    Campion, M.3
  • 86
    • 0013619852 scopus 로고    scopus 로고
    • The evolution of neutralising antibodies in patients taking beta interferon 1b
    • Rice G, Lesaux J, Ebers G. The evolution of neutralising antibodies in patients taking beta interferon 1b [abstract]. Mult Scler 1997; 3: 344
    • (1997) Mult Scler , vol.3 , pp. 344
    • Rice, G.1    Lesaux, J.2    Ebers, G.3
  • 87
    • 0001372691 scopus 로고    scopus 로고
    • Comparison of ELISA with MxA assay for the detection of antibodies to interferon-beta and results of long-term follow-up
    • Oger J, Paszner B, Paty DW. Comparison of ELISA with MxA assay for the detection of antibodies to interferon-beta and results of long-term follow-up [abstract]. Neurology 1998; 50: A342
    • (1998) Neurology , vol.50
    • Oger, J.1    Paszner, B.2    Paty, D.W.3
  • 88
    • 0013593988 scopus 로고    scopus 로고
    • The evolution of neutralizing antibodies in patients treated with interferon
    • In press
    • Rice G, Paszner B, Oger J, et al. The evolution of neutralizing antibodies in patients treated with interferon. Neurology 1999. In press
    • (1999) Neurology
    • Rice, G.1    Paszner, B.2    Oger, J.3
  • 89
    • 0000486740 scopus 로고    scopus 로고
    • The MS PRISMS Study: Prevention of relapses and disability by interferon beta 1a subcutaneously in multiple sclerosis
    • Ebers GC, Oger J, Paty DW, et al. The MS PRISMS Study: prevention of relapses and disability by interferon beta 1a subcutaneously in multiple sclerosis [abstract]. Ann Neurol 1997; 42: 986
    • (1997) Ann Neurol , vol.42 , pp. 986
    • Ebers, G.C.1    Oger, J.2    Paty, D.W.3
  • 91
    • 0013590484 scopus 로고    scopus 로고
    • A novel bioassay for the determination of neutralizing antibodies to interferon beta-1b
    • In press
    • Pungor E Jr, Files JG, Gabe JD, et al. A novel bioassay for the determination of neutralizing antibodies to interferon beta-1b. J Interferon Res 1999. In press
    • (1999) J Interferon Res
    • Pungor E., Jr.1    Files, J.G.2    Gabe, J.D.3
  • 92
    • 0030853665 scopus 로고    scopus 로고
    • Anticytokine antibodies in beta interferon-treated MS patients and the need for testing: Plight of the practicing neurologist
    • Pachner AR. Anticytokine antibodies in beta interferon-treated MS patients and the need for testing: plight of the practicing neurologist. Neurology 1997; 49: 647-50
    • (1997) Neurology , vol.49 , pp. 647-650
    • Pachner, A.R.1
  • 93
    • 0021716438 scopus 로고
    • A radioimmunologic technique to screen for antibodies to alpha-2 interferon
    • Protzman WP, Jacobs SL, Minnicozzi M, et al. A radioimmunologic technique to screen for antibodies to alpha-2 interferon. J Immunol Meth 1984; 75: 317-23
    • (1984) J Immunol Meth , vol.75 , pp. 317-323
    • Protzman, W.P.1    Jacobs, S.L.2    Minnicozzi, M.3
  • 94
    • 0002843598 scopus 로고    scopus 로고
    • Quantitation and characterisation of multiple sclerosis patient antibodies to interferon-beta
    • Reder AT, editor. New York: Marcel Dekker
    • Nestaas E, Files JG, Nelson JW, et al. Quantitation and characterisation of multiple sclerosis patient antibodies to interferon-beta. In: Reder AT, editor. Interferon therapy of multiple sclerosis. New York: Marcel Dekker, 1997: 523-30
    • (1997) Interferon Therapy of Multiple Sclerosis , pp. 523-530
    • Nestaas, E.1    Files, J.G.2    Nelson, J.W.3
  • 95
    • 0027058692 scopus 로고
    • A whole blood immunoassay for the interferon-inducible human Mx protein
    • Towbin H, Schmitz A, Jakschies D, et al. A whole blood immunoassay for the interferon-inducible human Mx protein. J Interferon Res 1992; 12: 67-74
    • (1992) J Interferon Res , vol.12 , pp. 67-74
    • Towbin, H.1    Schmitz, A.2    Jakschies, D.3
  • 96
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Moosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Immunol Methods 1983; 65: 55-63
    • (1983) Immunol Methods , vol.65 , pp. 55-63
    • Moosmann, T.1
  • 97
    • 0023235133 scopus 로고
    • The detection of antibodies to recombinant interferon alfa-2a in human serum
    • Hennes U, Jucker W, Fischer EA, et al. The detection of antibodies to recombinant interferon alfa-2a in human serum. J Biol Stand 1987; 15: 231-44
    • (1987) J Biol Stand , vol.15 , pp. 231-244
    • Hennes, U.1    Jucker, W.2    Fischer, E.A.3
  • 98
    • 0002424035 scopus 로고    scopus 로고
    • In Betaseron treated MS patients, in vitro immune function can be a predictor of neutralising antibody development
    • Oger J, Vorobeychick G, Paty DW. In Betaseron treated MS patients, in vitro immune function can be a predictor of neutralising antibody development [abstract]. Neurology 1997; 48: A80
    • (1997) Neurology , vol.48
    • Oger, J.1    Vorobeychick, G.2    Paty, D.W.3
  • 99
    • 0031445888 scopus 로고    scopus 로고
    • Neutralising antibodies and the efficacy of interferon beta-1b in relapsing-remitting multiple sclerosis
    • Petkau J, White R. Neutralising antibodies and the efficacy of interferon beta-1b in relapsing-remitting multiple sclerosis [abstract]. Mult Scler 1997; 3: 402
    • (1997) Mult Scler , vol.3 , pp. 402
    • Petkau, J.1    White, R.2
  • 100
    • 0030690917 scopus 로고    scopus 로고
    • Neutralising antibodies: Are they an issue?
    • Arnason BGW. Neutralising antibodies: are they an issue? Int Mult Scler J 1997; 4: 40-42
    • (1997) Int Mult Scler J , vol.4 , pp. 40-42
    • Arnason, B.G.W.1
  • 101
    • 0027239843 scopus 로고
    • Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anticytokine antibody complexes
    • Finkelman FD, Madden KB, Morris SC, et al. Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anticytokine antibody complexes. J Immunol 1993; 151: 1235-44
    • (1993) J Immunol , vol.151 , pp. 1235-1244
    • Finkelman, F.D.1    Madden, K.B.2    Morris, S.C.3
  • 102
    • 0019732416 scopus 로고
    • Humoral immunity in myasthenia gravis: Clinical correlations of anti-receptor antibody avidity and titer
    • Tindall RSA. Humoral immunity in myasthenia gravis: clinical correlations of anti-receptor antibody avidity and titer. Ann NY Acad Sci 1981; 377: 316-31
    • (1981) Ann NY Acad Sci , vol.377 , pp. 316-331
    • Tindall, R.S.A.1
  • 103
    • 0019308685 scopus 로고
    • Circulating insulin-binding antibodies
    • Kurtz AB, Nabarro JDN. Circulating insulin-binding antibodies. Diabetologia 1980; 19: 329-34
    • (1980) Diabetologia , vol.19 , pp. 329-334
    • Kurtz, A.B.1    Nabarro, J.D.N.2
  • 104
    • 0018849975 scopus 로고
    • Insulin-induced lipoatrophy: Evidence for an immune pathogenesis
    • Reeves WG, Allen BR, Tattersall RB. Insulin-induced lipoatrophy: evidence for an immune pathogenesis. BMJ 1980; 280: 1500-3
    • (1980) BMJ , vol.280 , pp. 1500-1503
    • Reeves, W.G.1    Allen, B.R.2    Tattersall, R.B.3
  • 105
    • 0016791418 scopus 로고
    • Insulin antibodies and the control of diabetes
    • Dixon K, Exon PD, Malins JM. Insulin antibodies and the control of diabetes. Q J Med 1975; 44: 543-53
    • (1975) Q J Med , vol.44 , pp. 543-553
    • Dixon, K.1    Exon, P.D.2    Malins, J.M.3
  • 106
    • 0020549604 scopus 로고
    • The bioavailability of circulating antibody-bound insulin following insulin withdrawal in type I (insulin-dependent) diabetes
    • Vaughan NJA, Matthews JA, Kurtz AB, et al. The bioavailability of circulating antibody-bound insulin following insulin withdrawal in type I (insulin-dependent) diabetes. Diabetologia 1983; 24: 355-8
    • (1983) Diabetologia , vol.24 , pp. 355-358
    • Vaughan, N.J.A.1    Matthews, J.A.2    Kurtz, A.B.3
  • 107
    • 15144353777 scopus 로고    scopus 로고
    • Imaging of the buffering effect of insulin antibodies in the autoimmune hypoglycemic syndrome
    • Dozio N, Scavini M, Beretta A, et al. Imaging of the buffering effect of insulin antibodies in the autoimmune hypoglycemic syndrome. J Clin Endocrin Metab 1998; 83: 643-8
    • (1998) J Clin Endocrin Metab , vol.83 , pp. 643-648
    • Dozio, N.1    Scavini, M.2    Beretta, A.3
  • 108
    • 0017801756 scopus 로고
    • Diabetes and hypoglycemia due to insulin antibodies
    • Anderson JH, Blackard WG, Goldman J, et al. Diabetes and hypoglycemia due to insulin antibodies. Am J Med 1978; 64: 868-73
    • (1978) Am J Med , vol.64 , pp. 868-873
    • Anderson, J.H.1    Blackard, W.G.2    Goldman, J.3
  • 109
    • 0000977149 scopus 로고
    • Quantitative aspects of the reaction between insulin and insulin-binding antibody
    • Berson SA, Yalow RS. Quantitative aspects of the reaction between insulin and insulin-binding antibody. J Clin Invest 1959; 38: 1996-2016
    • (1959) J Clin Invest , vol.38 , pp. 1996-2016
    • Berson, S.A.1    Yalow, R.S.2
  • 110
    • 0000522927 scopus 로고
    • 131I metabolism in human subjects: Demonstration of insulin binding globulin in the circulation of insulin-treated subjects
    • 131I metabolism in human subjects: demonstration of insulin binding globulin in the circulation of insulin-treated subjects. J Clin Invest 1956; 35: 170-90
    • (1956) J Clin Invest , vol.35 , pp. 170-190
    • Berson, S.A.1    Yalow, R.S.2    Bauman, A.3


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