Tumors of the thymus

Journal of Thoracic Imaging

Volumn 14, Issue 3, 1999, Pages 152-171

  Strollo, Diane C ^a   Rosado de Christenson, Melissa L ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

Carcinoma; Germ cell tumor; Lymphoma; Neoplasm; Thymoma; Thymus

Indexed keywords

ARTICLE; CANCER CLASSIFICATION; GERM CELL TUMOR; HUMAN; LYMPHOMA; MULTIPLE ENDOCRINE NEOPLASIA; THYMOMA; THYMUS CANCER; TUMOR CLASSIFICATION; TUMOR LOCALIZATION;

EID: 0032971025     PISSN: 08835993     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005382-199907000-00002     Document Type: Article

References (109)

1. Suster S, Moran CA. Thymic carcinoma: spectrum of differentiation and histologic types. Pathology 1998;30:111-23.
2. Wychulis AR, Payne WS, Clagett OT, Woolner LB. Surgical treatment of mediastinal tumors. J Thorac Cardiovasc Surg 1972; 62:379-91.
3. Thymus, lymph nodes, spleen, and lymphatics. In: Henry K, Symmers W, eds. Systemic pathology. 3rd ed. Edinburgh: Churchill Livingstone, 1992.
4. Rosenow EC, Hurley BT. Disorders of the thymus. Arch Intern Med 1984;144:763-70.
5. Gilmour JR. Some developmental abnormalities of the thymus and parathyroids. J Pathol Bacteriol 1941;52:213-8.
6. Rosai J, Levine GD, eds. Tumors of the thymus. Atlas of tumor pathology. 2nd ed. Washington, DC: Armed Forces Institute of Pathology, 1987.
7. Drachman DB. Myasthenia gravis. N Engl J Med 1994;330:1797-810.
8. Levine GD, Rosai J. Thymic hyperplasia and neoplasia: a review of current concepts. Hum Pathol 1978;9:495-515.
9. Indeglia RA, Shea MA, Grage TB. Congenital cysts of the thymus gland. Arch Surg 1967;94:149-52.
10. Suster S, Rosai J. Multilocular thymic cyst: an acquired reactive process. Am J Surg Pathol 1991;15:388-98.
11. Leonidas JC, Berdon WE, Valderrama E, et al. Human immunodeficiency virus infection and multilocular thymic cysts. Radiology 1996;198:377-9.
12. Avila NA, Mueller BU, Carrasquillo JA, Kontny HU, Jaffe ES, Pizzo PA. Multilocular thymic cysts: imaging features in children with human immunodeficiency virus infection. Radiology 1996; 201:130-4.
13. Gonullu U, Gungor A, Savas I, Ozdemir O, Mogulkoc G, Alper D, et al. Huge thymic cysts. J Thorac Cardiovasc Surg 1996; 112:835-6.
14. Graeber GM, Thompson LD, Cohen DJ, Ronnigen LD, Jaffin J, Zajtchuk R. Cystic lesions of the thymus. J Thorac Cardiovasc Surg 1984;87:295-300.
15. Edington H, Salwitz J, Longo DL, Roth JA, Pass H. Thymic hyperplasia masquerading as recurrent Hodgkin's disease: case report and review of the literature. J Surg Oncol 1986;33:120-3.
16. Simmonds P, Silverstein M, McKendrick J. Thymic hyperplasia in adults following chemotherapy for malignancy. Aust N Z J Med 1993;23:264-7.
17. Luketich JD, Jett JR. The current management of thymic tumors. Semin Respir Crit Care Med 1997;18:375-81.
18. Sloan HE. The thymus in myasthenia gravis with observations on the normal anatomy and histology of the thymus. Surgery 1943; 13:154-74.
19. Kushihashi T, Fujisawa H, Munechika H. Magnetic resonance imaging of thymic epithelial tumors. Crit Rev Diagn Imag 1996; 37:191-259.
20. Burns DF, Schiffman FJ. Beguiled by the gallium: thymic rebound in an adult after chemotherapy for Hodgkin's disease. Chest 1993;104:1916-9.
21. Marx A, Wilisch A, Schultz A, Gattenlohner S, Nenninger R, Muller-Hermelink HK. Pathogenesis of myasthenia gravis. Virchows Arch 1997;430:355-64.
22. Nicolaou S, Muller NL, Li DK. Thymus in myasthenia gravis: comparison of CT and pathologic findings and outcome after thymectomy. Radiology 1996;201:471-4.
23. Osserman KE, Genkins G. Studies in myasthenia gravis: review of 20-year experience in over 1200 patients. Mt Sinai J Med 1971;38:497-537.
24. Benjamin SP, McCormack LJ, Effler DB, Groves LK. Primary tumors of the mediastinum. Chest 1972;62:297-303.
25. Morgenthaler TI, Brown LR, Colby TV, Harper CM, Coles DT. Thymoma. Mayo Clin Proc 1993;63:1110-23.
26. Wilkins EW Jr, Edmunds LH Jr, Castleman B. Cases of thymoma at the Massachusetts General Hospital. J Thorac Cardiovasc Surg 1966;52:322-30.
27. Blumberg D, Port JL, Weksler B, Delgado R, Rosai J, Bains MS, et al. Thymoma: a multivariate analysis of factors predicting survival. Ann Thorac Surg 1995;60:908-14.
28. Lewis JE, Wick MR, Scheithauer BW, Bernatz PE, Taylor WF. Thymoma: a clinicopathologic review. Cancer 1987;60:2727-43.
29. Souadjian JV, Enriquez P, Silverstein MN, Pepin J-M. The spectrum of diseases associated with thymoma: coincidence or syndrome. Arch Intern Med 1974;134:374-9.
30. Walderman TA. Thymoma, hypogammaglobulinemia, and absence of eosinophils. J Clin Invest 1967;46:1127-8.
31. Kohman LJ. Controversies in the management of malignant thymoma. Chest 1997;112(4 suppl):296-300.
32. Schmidt R, Monig SP, Selzner M, Krug B. Surgical therapy of malignant thymoma. J Cardiovasc Surg 1997;38:317-22.
33. Verstandig AG, Epstein DM, Miller WT, Aronchik JA, Gefter WB, Miller WT. Thymoma-report of 71 cases and a review. Crit Rev Diagn Imag 1992;33:201-30.
34. Rosado de Christenson ML, Galobardes J, Moran CA. Thymoma: radiologic-pathologic correlation. RadioGraphics 1992;12:151-68.
35. Lattes R. Thymoma and other tumors of the thymus: an analysis of 107 cases. Cancer 1962;15:1224-60.
36. Do YS, Im JG, Lee BH, et al. CT findings of malignant tumors of thymic epithelium. J Comput Assist Tomogr 1995;19:192-7.
37. Moran CA, Travis WD, Rosado de Christenson ML, Koss MN, Rosai J. Thymomas presenting as pleural tumors. Am J Surg Pathol 1992;16:138-44.
38. Sakai F, Sone S, Kiyono K, et al. MR imaging of thymoma: radiologic-pathologic correlation. AJR 1992;158:751-6.
39. Currans WJ, Kornstein MJ, Brooks JT, Turrisi AT. Invasive thymoma: the role of mediastinal irradiation following complete or incomplete surgical resection. J Clin Oncol 1988;6:1722-7.
40. Loehrer PJ, Kim KM, Aisner SC, Livingston R, Einhorn LH, Johnson D, Blum R. Cisplatin plus doxorubicin plus cyclophosphamide in metastatic or recurrent thymoma. J Clin Oncol 1994; 12:1164-8.
41. Shin DM, Walsh GL, Komaki R, et al. A multidisciplinary approach to therapy for unresectable malignant thymoma. Ann Intern Med 1998;129:100-4.
42. Maggi G, Giaccone G, Donadio M, et al. Thymomas: a review of 169 cases with particular reference to results of surgical treatment. Cancer 1986;58:765-76.
43. Regnard JF, Zinzindohoue F, Magdeleinat P, Uibert L, Spaggiari L, Evasseur P. Results of re-resection for recurrent thymomas. Ann Thorac Surg 1997;64:1593-8.
44. Blumberg D, Burt ME, Bains MS, Downey RJ, Martine N, Rusch V, Ginsberg RJ. Thymic carcinoma: current staging does not predict prognosis. J Thorac Cardiovasc Surg 1998;115:303-8.
45. Wick MR, Weiland LH, Scheithauer BW, Bernatz PE. Primary thymic carcinomas. Am J Surg Pathol 1982;6:613-30.
46. Quagliano PV. Thymic carcinoma: case reports and review. J Thorac Imag 1996;11:66-74.
47. Weide LG, Ulbright TM, Loehrer PF, Williams SD. Thymic carcinoma. Cancer 1993;71:1219-23.
48. Buck JL, Sobin LH. Carcinoids of the gastrointestinal tract. RadioGraphics 1990;10:1081-95.
49. Tumors of the lower respiratory tract. In: Colby TV, Koss MN, Travis WD, eds. Atlas of tumor pathology. Washington, DC: Armed Forces Institute of Pathology, 1995:287-317.
50. Dusmet ME, McKneally MF. Pulmonary and thymic carcinoid tumors. World J Surg 1996;20:189-95.
51. Kornstein MJ, de Blois GG, eds. Pathology of the thymus and mediastinum. In: Neuroendocrine tumors: carcinoid and paraganglioma. Philadelphia: W. B. Saunders, 1995.
52. Teh BT. Thymic carcinoid tumors in multiple endocrine neoplasia type 1. J Intern Med 1998;243:501-4.
53. Tumors of the thymus and related lesions. In: Shimosato Y, Mukai K, eds. Atlas of tumor pathology. Tumors of the mediastinum. Washington DC: Armed Forces Institute of Pathology, 1997:158-168.
54. Economoupolos GC, Lewis JW Jr, Lee MW, Silverman NA. Carcinoid tumors of the thymus. Ann Thorac Surg 1990;50:58-61.
55. de Montpreville VT, Macchiarini P, Dulmet E. Thymic neuroendocrine carcinoma (carcinoid): a clinicopathologic study of fourteen cases. J Thorac Cardiovasc Surg 1996;111:134-41.
56. Lastoria S, Vergara E, Palmieri G, et al. In vivo detection of malignant thymic masses by Indium-111-DTPA-D-Pheoctreotide scintigraphy. J Nucl Med 1998;39:634-9.
57. Cadigan DG, Hollett PD, Collingwood PW, Ur E. Imaging of mediastinal thymic carcinoid tumor with radiolabeled somatostatin analogue. Clin Nucl Med 1996;21:487-8.
58. Moran C, Rosado-de-Christenson M, Suster S. Thymolipoma: clinicopathologic review of 33 cases. Mod Pathol 1995;8:741-4.
59. Sidhu US, Malhotra V, Chhina GS. An unusual case of pseudocardiomegaly. Chest 1998;113:711-4.
60. Rosado de Christenson ML, Pugatch RD, Moran CA. Thymolipoma: analysis of 27 cases. Radiology 1994;193:121-6.
61. Davis RD Jr, Oldham NH Jr, Sabiston DC Jr. Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management and results. Ann Thorac Surg 1987;44:229-37.
62. Strickler JG, Kurtin PJ. Mediastinal lymphoma. Semin Diagn Pathol 1991;8:2-13.
63. Keller AR, Castleman B. Hodgkin's disease of the thymus gland. Cancer 1974;33:1615-23.
64. Lukes RJ, Butler JJ, Hicks EB. Natural history of Hodgkin's disease as related to its pathologic picture. Cancer 1966;19:317-44.
65. Castellino RA, Blank N, Hoppe RT, Cho C. Hodgkin disease: contributions of chest CT in the initial staging evaluation. Radiology 1986;160:603-5.
66. De Vita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 5th ed. Philadelphia: Lippincott-Raven, 1997.
67. Lichtenstein AK, Levine A, Taylor CR, Boswell W, Rossman S, Feinstein DI, Lukes RJ. Primary mediastinal lymphoma in adults. Am J Med 1980;68:509-14.
68. Kennedy BJ, Fremgen AM, Mench HR. The national cancer data base report on Hodgkin' disease for 1985-1989 and 1990-1994. Cancer 1998;83:1041-7.
69. Schomberg PJ, Evans RG, O'Connell MJ, White WL, Banks PM, Ilstrup DM, Earle JD. Prognostic significance of mediastinal mass in adult Hodgkin's disease. Cancer 1984;53:324-8.
70. Mann RB, Jaffe ES, Berard CW. Malignant lymphomas: a conceptual understanding of morphologic diversity. Am J Pathol 1979;94:105-76.
71. Keller AR, Kaplan HS, Lukes RJ, Rappaport H. Correlation of histopathology with other prognostic indicators in Hodgkin's disease. Cancer 1968;22:487-99.
72. Costello P, Jochelson M. Lymphoma of the mediastinum and lung. In: Taveras JM, Ferrucci JT, eds. Radiology: Diagnosis-Imaging-Intervention. Philadelphia: Lippincott-Raven, 1998.
73. Kim HC, Nosher J, Haas A, Sweeney W, Lewis R. Cystic degeneration of thymic Hodgkin's disease following radiation therapy. Cancer 1985;55:354-6.
74. Romano M, Libshitz HI. Hodgkin disease and non-Hodgkin lymphoma: plain chest radiographs and chest computed tomography of thoracic involvement in previously untreated patients. Radiol Med 1998;95:49-53.
75. Castellino RA. The non-Hodgkin's lymphomas: practical concepts for the diagnostic radiologist. Radiology 1991;178:315-21.
76. Kaesberg PR, Foley DB, Pellett J, Hafez GR, Ershler WB. Concurrent development of a thymic cyst and Hodgkins's disease. Med Pediatr Oncol 1988;16:293-4.
77. Filly R, Blank N, Castellino RA. Radiographic distribution of intrathoracic disease in previously untreated patients with Hodgkin's disease and non-Hodgkin's lymphoma. Radiology 1976; 120:277-81.
78. Negendank WG, Al-Katib AM, Karanes C, Smith MR. Lymphomas: MR imaging contrast characteristics with clinical-pathologic correlation. Radiology 1990;177:209-16.
79. Rahmouni A, Tempany C, Jones R, Mann R, Yang A, Zerhouni E. Lymphoma: monitoring tumor size and signal intensity with MR imaging. Radiology 1993;188:445-51.
80. Radford JA, Cowan RA, Flanagan M, Dunn G, Crowther D, Johnson RJ, Eddleston B. The significance of residual mediastinal abnormality on the chest radiograph following treatment for Hodgkin's disease. J Clin Oncol 1988;6:940-6.
81. Spiers AS, Husband JE, MacVicar AD. Treated thymic lymphoma: comparison of MR imaging with CT. Radiology 1997; 203:369-76.
82. Webb WR. MR imaging of treated mediastinal Hodgkin disease. Radiology 1989;170:315-6.
83. Front D, Ben-Haim S, Isreal O, et al. Lymphoma: predictive value of Ga-67 scintigraphy after treatment. Radiology 1992;182:359-63.
84. Moog F, Bangerter M, Diederichs CG, Guhlmann A, Merkle E, Frickhofen N, Reske SN. Extranodal malignant lymphoma: detection with FDG PET versus CT. Radiology 1998;206:475-81.
85. Moog F, Bangerter M, Diederichs CG, et al. Lymphoma: role of whole-body 2-deoxy-2-[F-18] fluoro-D-glucose (FDG) PET in nodal staging. Radiology 1997;203:795-800.
86. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the international lymphoma study group. Blood 1994;84:1361-92.
87. Brasg DG, Colby TV, Ward JH. New concepts in the non-Hodgkin lymphomas: radiologic implications. Radiology 1986; 159:289-330.
88. Lazzarino M, Orlandi E, Paulli M, et al. Primary mediastinal B-cell lymphoma with sclerosis: an aggressive tumor with distinctive clinical and pathologic features. J Clin Oncol 1993;11: 2306-13.
89. Paulli M, Lazzarino M, Gianelli U, et al. Primary mediastinal B-cell lymphoma: update on its clinicopathologic features. Leukoc Lymphoma 1997;26(suppl 1):115-23.
90. Chim CS, Liang R, Chan AC, Kwong YL, Ho FC, Todd D. Primary B cell lymphoma of the mediastinum. Hematol Oncol 1996;14:173-9.
91. Shikano T, Arioka H, Kobayashi R, et al. Acute lymphoblastic leukemia and non-Hodgkin's lymphoma with mediastinal mass: a study of 23 children: different disorders or different stages? Leukoc lymphoma 1994;13:161-7.
92. Ellert J, Kreel L. The role of computed tomography in the initial staging and subsequent management of the lymphomas. J Comput Assist Tomogr 1980;4:368-91.
93. Rosado-de-Christenson ML, Templeton PA, Moran CA. Mediastinal germ cell tumors: radiologic and pathologic correlation. RadioGraphics 1992;12:1013-30.
94. Moran CA, Suster S, Przygodzki RM, Koss MN. Primary germ cell tumors of the mediastinum. 2. Mediastinal seminomas: a clinicopathologic and immunohistochemical study of 120 cases. Cancer 1997;80:681-8.
95. Scully RE, Mark EJ, McNeely WF, Ebeling SH, Phillips LD. Case records of the Massachusetts General Hospital: acute megakaryoblastic leukemia in a patient with mediastinal germ cell tumor. N Engl J Med 1997;337:1904-12.
96. Nichols CR. Mediastinal germ cell tumors: clinical features and biologic correlates. Chest 1991;99:472-9.
97. Moran CA, Suster S. Primary germ cell tumors of the mediastinum. 1. Analysis of 322 cases with special emphasis on teratomatous lesions and a proposal for histopathologic classification and clinical staging. Cancer 1997;80:681-90.
98. Moeller KH, Rosado-de-Christenson ML, Templeton PA. Mediastinal mature teratoma: imaging features. AJR 1997;169:985-90.
99. Sasaka K, Kurihara Y, Nakajima Y, Seto Y, Endo I, Shikawa T, Takagi M. Spontaneous rupture: a complication of benign mature teratomas of the mediastinum. AJR 1998;170:323-8.
100. Lewis BD, Hurt RD, Payne WS, Farrow GM, Knapp RH, Muhm JR. Benign teratoma of the mediastinum. J Thorac Cardiovasc Surg 1983;86:727-31.
101. Arai K, Ohta S, Suzuki M, Suzuki H. Primary immature mediastinal teratoma in adulthood. Eur J Surg Oncol 1997;23:64-7.
102. Aygun C, Slawson RG, Bajaj K, Salazar OM. Primary mediastinal seminoma. Urology 1984;23:109-17.
103. Moran CA, Suster S. Mediastinal seminoma with prominent cystic changes. Am J Surg Pathol 1995;19:1047-53.
104. Shin MS, Ho KJ. Computed tomography of primary mediastinal seminomas. J Comput Assist Tomogr 1983;7:990-4.
105. Sandler A, Nichols C. Mediastinal germ cell tumors. Semin Respir Critic Care Med 1997;18:383-92.
106. Bukowski RM, Wolf M, Kulander BG, Montie J, Crawford ED, Blumenstein B. Alternating combination chemotherapy in patients with extragonadal germ cell tumors: a Southwest Oncology Group Study. Cancer 1993;71:2631-8.
107. Jyothirmayi R, Ramadas K, Jacob R, Gangadharan VP, Nair MK. Primary malignant germ cell tumors of the mediastinum: results of multimodality treatment. Acta Oncol 1997;36:317-21.
108. Moran CA, Suster S, Koss MN. Primary germ cell tumors of the mediastinum. 3. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum - a clinicopathologic and immunohistochemical study of 64 cases. Cancer 1997;80:699-707.
109. Afifi HY, Bosl GJ, Burt ME. Mediastinal growing teratoma syndrome. Ann Thorac Surg 1997;64:359-62.