Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 7, 1999, Pages 1413-1423

  Kaminski, James J ^a   Carruthers, Nicholas I ^a   Wong, Shing Chun ^a   Chan, Tze Ming ^a   Motassim Billah, M ^a   Tozzi, S ^a   McPhail, Andrew T ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

Conformational analysis; H1 receptor antagonist; Molecular modeling; Platelet activating factor (PAF); Rigid analogues

Indexed keywords

1 ACETYL 4 (8 CHLORO 5,6 DIHYDRO 11H BENZO [5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YL)PIPERAZINE DERIVATIVE; 1 ACETYL 4 (8 CHLORO 5,6 DIHYDRO 11H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YLIDENE)PIPERIDINE; AZATADINE; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; LORATADINE; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; THROMBOCYTE AGGREGATION;

ANIMALS; ANTI-ALLERGIC AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; HISTAMINE ANTAGONISTS; HUMANS; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; LORATADINE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; PIPERAZINES; PIPERIDINES; PLATELET ACTIVATING FACTOR; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PYRIDINES; RATS; RECEPTORS, HISTAMINE H1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032970978     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00075-9     Document Type: Article

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