Quantitative analysis of Z-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol in human plasma using high-performance liquid chromatography

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 724, Issue 1, 1999, Pages 163-171

  Taras, Tracy L ^a   Wurz, Gregory T ^a   Hellmann Blumberg, Utha ^a   DeGregorio, Michael W ^a  

^a Division of Hematology Oncology   (United States)

Author keywords

FC 1271a; Triphenylethylene; Z 2 4 (4 chloro 1,2 diphenyl but 1 enyl)phenoxy ethanol

Indexed keywords

2 [4 (4 CHLORO 1,2 DIPHENYL BUT 1 ENYL)PHENOXY]ETHANOL; ANTIESTROGEN; OSPEMIFENE; TOREMIFENE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; EXTRACTION; FLUORESCENCE; HUMAN; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTROGEN ANTAGONISTS; FREEZING; HUMANS; MACACA MULATTA; PHOTOCHEMISTRY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, FLUORESCENCE; TAMOXIFEN;

EID: 0032970908     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(98)00571-4     Document Type: Article

References (7)

1. M. DeGregorio, V. Wiebe, L. Kangas, P. Härkönen, K. Väänänen, A. Laine, U.S. Pat. 5,750,576, May 12, 1998.
2. M.W. DeGregorio, G.T. Wurz, U. Hellmann-Blumberg, Pharmacol. Toxicol. (1998), submitted.
3. Holleran W.M., Gharbo S.A., DeGregorio M.W. Quantitation of toremifene and its major metabolites in human plasma by high-performance liquid chromatography following fluorescent activation. Anal. Lett. 20:(6):1987;871-879.
4. Wilbur B.J., Benz C.C., DeGregorio M.W. Quantitation of tamoxifen, 4-hydroxytamoxifen, and N-desmethyltamoxifen in human plasma by high-performance liquid chromatography. Anal. Lett. 18:(B15):1985;1915-1924.
5. Hasan S.A., Wiebe V.J., Cadman K.S., DeGregorio M.W. Quantitative analysis of toremifene metabolites in biological specimens using high-performance liquid chromatography. Anal. Lett. 23:(2):1990;327-334.
6. Krouwer J.S., Rabinowitz R. How to improve estimates of imprecision. Clin. Chem. 30:1984;290-292.
7. Brown R.R., Bain R., Jordan V.C. Determination of tamoxifen and metabolites in human serum by high-performance liquid chromatography with post-column fluorescence activation. J. Chromatogr. 272:(2):1983;351-358.