Isolation, tissue expression, and chromosomal assignment of a human LIM protein gene, showing homology to rat Enigma homologue (ENH)

Journal of Human Genetics

Volumn 44, Issue 4, 1999, Pages 256-260

  Ueki, Nobuhide ^a   Seki, Naohiko ^b   Yano, Kazuhiro ^a   Masuho, Yasuhiko ^a   Saito, Toshiyuki ^b   Muramatsu, Masa Aki ^a,c  

^a Helix Research Institute   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

4q22; Chromosome mapping; Enigma; Enigma homolog (ENH); LIM domain

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; MESSENGER RNA; PROTEIN KINASE C;

ARTICLE; CHROMOSOME 4Q; GENE ASSIGNMENT; GENE EXPRESSION; GENE ISOLATION; GENE MAPPING; HEART; HUMAN; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; SKELETAL MUSCLE;

EID: 0032970843     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380050155     Document Type: Article

References (29)

1. Archer VE, Breton J, Sanchez-Garcia I, Osada H, Forster A, Thomson AJ, Rabbitts TH (1994) Cysteine-rich LIM domains of LIM-homeodomain and LIM-only proteins contain zinc but not iron. Proc Natl Acad Sci USA 91:316-320
2. Bell RM, Burns DJ (1991) Lipid activation of protein kinase C. J Biol Chem 266:4661-4664
3. Crawford AW, Pino JD, Beckerle MC (1994) Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton. J Cell Biol 124:117-112
4. Dawid IB, Toyama R, Taira M (1995) LIM domain proteins. C R Acad Sci III 318:295-306
5. Dawid IB, Breen JJ, Toyama R (1998) LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Trends Genet 14:156-162
6. Dekker LV, Parker PJ (1994) Protein kinase C - a question of specificity. Trends Biochem Sci 19:73-77
7. Freyd G. Kim SK, Horvitz HR (1990) Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11. Nature 344:876-879
8. Hug H, Sarre TF (1993) Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291:329-343
9. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998) Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res 5:169-176
10. Karlsson O, Thor S, Norberg T, Ohlsson H, Edlund T (1990) Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature 344:879-882
11. Kiess M, Scharm B, Aguzzi A, Hajnal A, Klemenz R, Schwarte-Waldhoff I, Schafer R (1995) Expression of ril, a novel LIM domain gene, is down-regulated in Hras-transformed cells and restored in phenotypic revertants. Oncogene 10:61-68
12. Klug A, Schwabe JW (1995) Protein motifs 5. Zinc fingers. FASEB J 9:597-604
13. Kosa JL, Michelsen JW, Louis HA, Olsen JI, Davis DR, Beckerle MC, Winge DR (1994) Common metal ion coordination in LIM domain proteins. Biochemistry 33:468-477
14. Kuroda S, Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, Gill GN, Kikkawa U (1996) Protein protein interaction of zinc finger LIM domains with protein kinase C. J Biol Chem 271:31029-31032
15. Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE (1990) characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. Nucleic Acids Res 18:3871-3879
16. Macalma T, Otte J, Hensler ME, Bockholt SM, Louis HA, Kalff-Suske M, Grzeschik KH, von der Ahe D, Beckerle MC (1996) Molecular characterization of human zyxin. J Biol Chem 271:31470-31478
17. Michelsen JW, Schmeichel KL, Beckerle MC, Winge DR (1993) The LIM motif defines a specific zinc-binding protein domain. Proc Natl Acad Sci USA 90:4404-4408
18. Michelsen JW, Sewell AK, Louis HA, Olsen JI, Davis DR, Winge DR, Beckerle MC (1994) Mutational analysis of the metal sites in an LIM domain. J Biol Chem 269:11108-11113
19. Nishizuka Y (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-614
20. Nowaczyk MJ, Teshima IE, Siegel-Bartelt J, Clarke JT (1997) Deletion 4q21/4q22 syndrome: two patients with de novo 4q21.3q23 and 4q13.2q23 deletions. Am J Med Genet 69:400-405
21. Sadler I, Crawford AW, Michelsen JW, Beckerle MC (1992) Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol 119:1573-1587
22. Saito T, Seki N, Yamauchi M, Tsuji S, Hayashi A, Kozuma S, Hori T (1998) Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family. Biochem Biophys Res Commun 243:61-66
23. Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y, Pisick E, Hallek M, Ernst T (1995) Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. J Biol Chem 270:5039-5047
24. Sanchez-Garcia I, Rabbitts TH (1994) The LIM domain: a new structural motif found in zinc-finger-like proteins. Trends Genet 10:315-32
25. Seki N, Nimura Y, Ohira M, Saito T, Ichimiya S, Nomura N, Nakagawara A (1997) Identification and chromosome assignment of a human gene encoding a novel phosphatidylinositol-3 kinase. DNA Res 4:355-358
26. Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (1998) Selection system for genes encoding nuclear-targeted proteins. Nat Biotechnol 16:1338-1342
27. Wang X, Lee G, Liebhaber SA, Cooke NE (1992) Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc. J Biol Chem 267:9176-9184
28. Way JC, Chalfie M (1988) mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans. Cell 54:5-16
29. Wu RY, Gill GN (1994) LIM domain recognition of a tyrosine-containing tight turn. J Biol Chem 269:25085-25090