Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the 'a' epitope of the surface antigen are sensitive to ganciclovir

Antiviral Research

Volumn 41, Issue 3, 1999, Pages 113-118

  Jin Oon, Chong ^a   Ning Chen, Wei ^a   Lim, Nichole ^a   Koh, Shiuan ^a   Keow Lim, Gek ^a   Lin Leong, Ai ^a   San Tan, Gek ^a  

^a NONE

Author keywords

DNA polymerase; Ganciclovir; HBsAg; Hepatitis B virus; Lamivudine related mutations

Indexed keywords

ANTIVIRUS AGENT; DNA DIRECTED DNA POLYMERASE ALPHA; DNA POLYMERASE; EPITOPE; GANCICLOVIR; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; LYMPHOBLAST INTERFERON; VIRUS DNA;

ADULT; ARTICLE; CASE REPORT; DRUG RESISTANCE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS MUTATION;

ADULT; AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE, MICROBIAL; DRUG THERAPY, COMBINATION; EPITOPES; GANCICLOVIR; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; LAMIVUDINE; MALE; MOLECULAR SEQUENCE DATA; MUTATION;

HEPATITIS B VIRUS;

EID: 0032970767     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(99)00007-8     Document Type: Article

References (10)

1. Bartholomew M.M., Jansen R.W., Jeffers L.J., Reddy K.R., Johnson L.C., Bunzendahl H., Condreay L.D., Tzakis A.G., Schiff E.R., Brown N.A. Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation. Lancet. 349:1997;20-22.
2. Carman W.F., Korula J., Wallace L., MacPhee R., Mimms L., Decker R. Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA. Lancet. 345:1995;1406-1407.
3. Carman W.F., Van Deursen F.J., Mimms L.T., Hardie D., Coppola R., Decker R., Sanders R. The prevalence of surface antigen variants of hepatitis B virus in Papua New Guinea, South Africa, and Sardinia. Hepatology. 26:1997;1658-1666.
4. Dienstag J.L., Perrillo R.P., Schiff E.R., Bartholomew M., Vicary C., Rubin M. A preliminary trial of lamivudine for chronic hepatitis B infection. N. Engl. J. Med. 333:1995;1657-1661.
5. Honkoop P., Niesters H.G., de Man R.A., Osterhaus A.D., Schalm S.W. Lamivudine resistance in immunocompetent chronic hepatitis B. J. Hepatol. 26:1997;1393-1395.
6. Lai C.-L., Ching C.-K., Tung A., Li E., Young J., Hill A., Wong B., Dent J., Wu P.-C. Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: a placebo-controlled trial. Hepatology. 25:1997;241-244.
7. Locarnini S. Hepatitis B virus surface antigen and polymerase gene variants: potential virological and clinical significance. Hepatology. 27:1998;294-297.
8. Oon C.-J., Lim G.K., Ye Z., Goh K.-T., Tan K-.L., Yo S.-L., Hopes E., Harrison T.J., Zuckerman A.J. Molecular epidemiology of hepatitis B virus vaccine variants in Singapore. Vaccine. 13:1995;699-702.
9. Oon C.-J., Chen W.N. Current aspects of hepatitis B surface antigen mutants in Singapore. J. Viral Hepatitis. 5:1998;17-24.
10. Poch O., Sauvaget I., Delarus M., Tordo N. Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO J. 8:1989;3867-3874.