A proposed molecular model for the interaction of calcineurin with the cyclosporin A-Cyclophilin a complex

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 7, 1999, Pages 1389-1402

  Ivery, Michael T G ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Immunological activity; Molecular modelling mechanics; Natural product

Indexed keywords

CALCINEURIN; CYCLOPHILIN A; CYCLOSPORIN; IMMUNOPHILIN; TACROLIMUS;

ARTICLE; BINDING SITE; CHEMICAL MODIFICATION; COMPLEX FORMATION; DRUG MECHANISM; DRUG STRUCTURE; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR MODEL;

AMINO ACID SUBSTITUTION; BINDING SITES; CALCINEURIN; COMPUTER SIMULATION; CYCLOSPORINE; IMMUNOPHILINS; IMMUNOSUPPRESSIVE AGENTS; MODELS, MOLECULAR; PEPTIDYLPROLYL ISOMERASE; PROTEIN CONFORMATION; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP; TACROLIMUS; TACROLIMUS BINDING PROTEINS;

RUMEX;

EID: 0032970430     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00072-3     Document Type: Article

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